Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD)

M. Sinan Aktaş; Emre Eren; Ömer Aydın; Kerim Emre Yanar; Sefa Küçükler; Muhammed Sertaç Eroğlu; Şükrü Değirmençay; Murat İlgün

Makale detayları

Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD)

Yazarlar:

M. Sinan Aktaş | Emre Eren | Ömer Aydın | Kerim Emre Yanar | Sefa Küçükler | Muhammed Sertaç Eroğlu | Şükrü Değirmençay | Murat İlgün

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.35 Issue 3, pp.196-201

Belge Tipi:

Makale

Yayın Tarihi:

11/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332163

pISSN:

2149-3359

Anahtar kelimeler:

Özet:

 Bovine respiratory disease BRD is a significant and costly disease in cattle, characterized by various infections with distinct causes and clinical signs. This study focuses on investigating some hematological and inflammatory parameters, as well as cathelicidin antimicrobial peptide CAMP parameters, in calves with BRD. Forty-two calves were allocated to three groups based on clinical scoring: Group I n10, healthy, score 0, Group II n16, BRD, score 3, and Group III n16, BRD, score 4. Some hematological WBC, NEU, LYM, NLR, and PLT, inflammatory IL-1β, TNF-α, NF-ĸB, and IL-10, and CAMP parameters were evaluated in all groups. Group III had significantly higher WBC, NEU, and NLR concentrations than Group I, while concentrations of PLT in Group II were higher than Group I p0.05. NF-ĸB, TNF-α, and CAMP levels were enhanced in Group III compared to Group I, and CAMP levels were higher in Group II than in Group I p0.05. Strong positive correlations were found between NEU and WBC and NLR. Weak positive correlations existed between WBC, NEU, IL-10, and CAMP, as well as between LYM and IL-1β and NF-ĸB and CAMP. In conclusion, the most severe inflammation was observed in Group III, aligning with clinical scoring in BRD-affected calves. CAMP was identified as a reliable marker for inflammation assessment. Additionally, NLR, being low-cost and easily measurable, showed promise as an inflammation indicator.

 Bovine respiratory disease BRD is a significant and costly disease in cattle, characterized by various infections with distinct causes and clinical signs. This study focuses on investigating some hematological and inflammatory parameters, as well as cathelicidin antimicrobial peptide CAMP parameters, in calves with BRD. Forty-two calves were allocated to three groups based on clinical scoring: Group I n10, healthy, score 0, Group II n16, BRD, score 3, and Group III n16, BRD, score 4. Some hematological WBC, NEU, LYM, NLR, and PLT, inflammatory IL-1β, TNF-α, NF-ĸB, and IL-10, and CAMP parameters were evaluated in all groups. Group III had significantly higher WBC, NEU, and NLR concentrations than Group I, while concentrations of PLT in Group II were higher than Group I p0.05. NF-ĸB, TNF-α, and CAMP levels were enhanced in Group III compared to Group I, and CAMP levels were higher in Group II than in Group I p0.05. Strong positive correlations were found between NEU and WBC and NLR. Weak positive correlations existed between WBC, NEU, IL-10, and CAMP, as well as between LYM and IL-1β and NF-ĸB and CAMP. In conclusion, the most severe inflammation was observed in Group III, aligning with clinical scoring in BRD-affected calves. CAMP was identified as a reliable marker for inflammation assessment. Additionally, NLR, being low-cost and easily measurable, showed promise as an inflammation indicator.

 Bovine respiratory disease BRD is a significant and costly disease in cattle, characterized by various infections with distinct causes and clinical signs. This study focuses on investigating some hematological and inflammatory parameters, as well as cathelicidin antimicrobial peptide CAMP parameters, in calves with BRD. Forty-two calves were allocated to three groups based on clinical scoring: Group I n10, healthy, score 0, Group II n16, BRD, score 3, and Group III n16, BRD, score 4. Some hematological WBC, NEU, LYM, NLR, and PLT, inflammatory IL-1β, TNF-α, NF-ĸB, and IL-10, and CAMP parameters were evaluated in all groups. Group III had significantly higher WBC, NEU, and NLR concentrations than Group I, while concentrations of PLT in Group II were higher than Group I p0.05. NF-ĸB, TNF-α, and CAMP levels were enhanced in Group III compared to Group I, and CAMP levels were higher in Group II than in Group I p0.05. Strong positive correlations were found between NEU and WBC and NLR. Weak positive correlations existed between WBC, NEU, IL-10, and CAMP, as well as between LYM and IL-1β and NF-ĸB and CAMP. In conclusion, the most severe inflammation was observed in Group III, aligning with clinical scoring in BRD-affected calves. CAMP was identified as a reliable marker for inflammation assessment. Additionally, NLR, being low-cost and easily measurable, showed promise as an inflammation indicator.

 Sığır solunum yolu hastalığı BRD, sığırlarda farklı nedenleri ve klinik belirtileri olan çeşitli enfeksiyonlarla karakterize önemli ve maliyetli bir hastalıktır. Bu çalışma, BRDli buzağılarda bazı hematolojik ve inflamatuvar parametrelerin yanısıra katelisidin antimikrobiyal peptid CAMP parametrelerinin araştırılmasına odaklanmıştır. 42 buzağı klinik skorlamaya gore üç gruba ayrılmıştır: Grup I n10, sağlıklı, skor 0, Grup II n16, BRD, skor 3 ve Grup III n16, BRD, skor 4. Bazı hematolojik WBC, NEU, LYM, NLR ve PLT, inflamatuvar IL-1β, TNF-α, NF-ĸBve IL-10 ve CAMP parametreleri değerlendirilmiştir. Grup IIIte WBC, NEU ve NLR konsantrasyonları Grup Ie göre istatistiksel olarak yüksekken, Grup IIde PLT konsantrasyonları Grup Ie göre istatistiksel olarak daha yüksekti p0.05. NF-ĸB, TNF-α ve CAMP düzeyleri Grup IIIte Grup Ie kıyasla artarken, CAMP düzeyleri Grup IIde Grup Ie kıyasla daha yüksekti p0.05. NEU ile WBC ve NLR arasında güçlü pozitif korelasyonlar bulundu. WBC, NEU, IL-10 ve CAMP arasında ve ayrıca LYM ile IL-1β ve NF-ĸB ile CAMP arasında zayıf pozitif korelasyonlar mevcuttu. Sonuç olarak, BRDden etkilenen buzağılarda klinik skorlama ile uyumlu olarak en şiddetli inflamasyon Grup IIIte gözlenmiştir. CAMP, inflamasyon değerlendirmesi için güvenilir bir belirteç olarak tanımlanmıştır. Ayrıca, düşük maliyetli ve kolay ölçülebilir NLR, bir yangı göstergesi olarak umut vaat etmektedir.

Makale detayları

Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD)

Yazarlar:

M. Sinan Aktaş | Emre Eren | Ömer Aydın | Kerim Emre Yanar | Sefa Küçükler | Muhammed Sertaç Eroğlu | Şükrü Değirmençay | Murat İlgün

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.35 Issue 3, pp.196-201

Belge Tipi:

Makale

Yayın Tarihi:

11/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332163

pISSN:

2149-3359

Anti-inflammatory

Bovine Respiratory Disease

Calf

Cathelicidin antimicrobial peptide

Neutrophil-Lymphocyte Ratio

Pro-inflammatory.Anti-inflamatuar

Sığır Solunum Hastalığı

Buzağı

Cathelicidin antimikrobiyal peptid

Nötrofil-Lenfosit Oranı

Pro-inflamatuar.

Sayı

Makale detayları

Yazarlar: M. Sinan Aktaş | Emre Eren | Ömer Aydın | Kerim Emre Yanar | Sefa Küçükler | Muhammed Sertaç Eroğlu | Şükrü Değirmençay | Murat İlgün

Yayıncı: Van Yuzuncu Yıl University

Ana Başlıklar: Veteriner İç Hastalıkları

Dergi: Van Veterinary Journal Vol.35 Issue 3, pp.196-201

Belge Tipi: Makale

Yayın Tarihi: 11/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001332163

pISSN: 2149-3359

Sayı

Yazarlar:

M. Sinan Aktaş | Emre Eren | Ömer Aydın | Kerim Emre Yanar | Sefa Küçükler | Muhammed Sertaç Eroğlu | Şükrü Değirmençay | Murat İlgün

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.35 Issue 3, pp.196-201

Belge Tipi:

Makale

Yayın Tarihi:

11/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332163

pISSN:

2149-3359