DESIGN, SYNTHESIS AND MOLECULAR DOCKING OF SOME DERIVATIVES OF 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO [3,4-f][1,2,4]TRIAZINE-3-THIOL

Sergey Fedotov; Andrey Gotsulya; Yevhen Zaika; Tetyana Brytanova

Makale detayları

DESIGN, SYNTHESIS AND MOLECULAR DOCKING OF SOME DERIVATIVES OF 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO [3,4-f][1,2,4]TRIAZINE-3-THIOL

Yazarlar:

Sergey Fedotov | Andrey Gotsulya | Yevhen Zaika | Tetyana Brytanova

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.336-348

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282811

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: The purpose of the work was to elaboration effective techniques for the synthesis of advanced condensed heterocyclic systems based on pyrazole and 1,2,4-triazole. In the process of realizing the set goal, a number of new pyrazolo1,5-d1,2,4triazolo3,4-f1,2,4triazines have been synthesized. Material and Method: Identity of synthesized compounds has been confirmed by elemental analysis, 1H-NMR, LC-MS techniques. The pharmacological potential of the obtained substances has been determined by molecular docking method.

 Objective: The purpose of the work was to elaboration effective techniques for the synthesis of advanced condensed heterocyclic systems based on pyrazole and 1,2,4-triazole. In the process of realizing the set goal, a number of new pyrazolo1,5-d1,2,4triazolo3,4-f1,2,4triazines have been synthesized. Material and Method: Identity of synthesized compounds has been confirmed by elemental analysis, 1H-NMR, LC-MS techniques. The pharmacological potential of the obtained substances has been determined by molecular docking method.

 Objective: The purpose of the work was to elaboration effective techniques for the synthesis of advanced condensed heterocyclic systems based on pyrazole and 1,2,4-triazole. In the process of realizing the set goal, a number of new pyrazolo1,5-d1,2,4triazolo3,4-f1,2,4triazines have been synthesized. Material and Method: Identity of synthesized compounds has been confirmed by elemental analysis, 1H-NMR, LC-MS techniques. The pharmacological potential of the obtained substances has been determined by molecular docking method.

 Amaç: Çalışmanın amacı, pirazol ve 1,2,4-triazole dayalı gelecek vaat eden kondanse heterosiklik sistemlerin sentezi için etkili yöntemler geliştirmektir. Belirlenen hedefi gerçekleştirme sürecinde, bir dizi yeni pirazolo1,5-d1,2,4triazolo3,4-f1,2,4triazin sentezlenmiştir. Gereç ve Yöntem: Sentezlenen bileşiklerin yapısı, element analizi, 1H-NMR, LC-MS teknikleri ile doğrulanmıştır. Elde edilen maddelerin farmakolojik potansiyeli moleküler modelleme yöntemi ile belirlenmiştir.

Makale detayları

DESIGN, SYNTHESIS AND MOLECULAR DOCKING OF SOME DERIVATIVES OF 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO [3,4-f][1,2,4]TRIAZINE-3-THIOL

Yazarlar:

Sergey Fedotov | Andrey Gotsulya | Yevhen Zaika | Tetyana Brytanova

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.336-348

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282811

pISSN:

1015-3918

1,2-diazole

1,2,4-triazole

chemistry

molecular docking

transformation

1,2-diazol

1,2,4-triazol

dönüşüm

kimya

moleküler yerleştirme

Sayı

Makale detayları

Yazarlar: Sergey Fedotov | Andrey Gotsulya | Yevhen Zaika | Tetyana Brytanova

Yayıncı: Ankara University

Ana Başlıklar: Eczacılık ve İlaç Bilimleri

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.336-348

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282811

pISSN: 1015-3918

Sayı

Yazarlar:

Sergey Fedotov | Andrey Gotsulya | Yevhen Zaika | Tetyana Brytanova

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.336-348

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282811

pISSN:

1015-3918