Relationship Between Whole Blood Viscosity and Lower Extremity Peripheral Artery Disease Severity

Mustafa YENERÇAĞ; Uğur ARSLAN; Metin ÇOKSEVİM; Seçkin DERELİ; Mustafa DOĞDUŞ; Güney ERDOĞAN

doi:https://doi.org/10.30565/medalanya.828026

Makale detayları

Relationship Between Whole Blood Viscosity and Lower Extremity Peripheral Artery Disease Severity

Yazarlar:

Mustafa YENERÇAĞ | Uğur ARSLAN | Metin ÇOKSEVİM | Seçkin DERELİ | Mustafa DOĞDUŞ | Güney ERDOĞAN

Yayıncı:

Alanya Alaaddin Keykubat University

Ana Başlıklar:

Hastalıklar

Dergi:

Acta Medica Alanya 2021 Vol.5 Issue 1, pp.66-74

Belge Tipi:

Makale

Yayın Tarihi:

4/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000439978

Sıklık:

Üç Yıllık

eISSN:

2587-0319

DOI:

https://doi.org/10.30565/medalanya.828026

Özet:

 


Aim: Increased blood viscosity (BV) has good correlaton with lower extremity peripheral artery disease (LEAD). However, the relationship between BV and peripheral arterial disease (PAD) severity has not been studied adequately so far. The aim of the present study was to assess the relationship between whole blood viscosity (WBV) and LEAD severity.

 Methods: The study included 240 consecutive patients with suspected PAD who had lower extremity peripheral angiography between March 2016 and March 2020. A Transatlantic İntersociety Consensus II (TASC II) A-B lesion was defined as simple LEAD, and a TASC II C-D lesion was defined as prevalent and complex LEAD. Symptom severity of all patients were categorized from 0 to 6 according to Rutherford classification. WBV was assessed using a validated calculation formula derived from hematocrit and total plasma protein levels, both at low (LSR) and high (HSR) shear rate.

 Results: TASC II C-D group presented significantly higher WBV values both at LSR (40.2 ± 9.5 vs. 46.5 ± 13.2; p < 0.001) and HSR (15.9 ± 0.5 vs. 16.5 ± 0,7; p < 0.001). In ROC analysis, a cut-off value of 16.1 WBV at HSR had 73.4% sensitivity and 68.0% specificity for predicting TASC II C-D (AUC: 76.2%, p < 0.001) and a cut-off value of 42.9 WBV at LSR had 73.4% sensitivity and 66.6% specificity for predicting TASC II C-D (AUC: 74.2%, p < 0.001). In multivariate analysis, both high WBV at LSR (OR: 2.121, 95% CI: 1.079 – 3.164, p < 0.001) and high WBV at HSR (OR: 2.737, 95% CI: 1.671 – 4.483, p < 0.001) were independent predictors for TASC II C-D. There was a significant positive correlation between WBV at LSR and Rutherford symptom category (0-6) (r = 0.412, p <0.001) and WBV at HSR and Rutherford symptom category (0-6) (r = 0.402, p <0.001).

 Conclusion: Our data suggests that; increased WBV values may be associated with TASC II C-D lesions, which indicated more prevalent and complex LEAD. Also WBV values positively correlated with Rutherford symptom severity.

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Amaç: Artmış kan viskozitesinin (BV) alt ekstremite periferik arter hastalığı (LEAD) ile iyi korelasyonu vardır. Ancak, BV ve peripherik arter hastalığı (PAD) şiddeti arasındaki ilişki şu ana kadar yeterince çalışılmamıştır. Bu çalışmanın amacı, tam kan viskozitesi (WBV) ve LEAD şiddeti arasındaki ilişkiyi değerlendirmektir.




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Makale detayları

Relationship Between Whole Blood Viscosity and Lower Extremity Peripheral Artery Disease Severity

Yazarlar: Mustafa YENERÇAĞ | Uğur ARSLAN | Metin ÇOKSEVİM | Seçkin DERELİ | Mustafa DOĞDUŞ | Güney ERDOĞAN

Yayıncı: Alanya Alaaddin Keykubat University

Ana Başlıklar: Hastalıklar

Dergi: Acta Medica Alanya 2021 Vol.5 Issue 1, pp.66-74

Belge Tipi: Makale

Yayın Tarihi: 4/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000439978

Sıklık: Üç Yıllık

eISSN: 2587-0319

DOI: https://doi.org/10.30565/medalanya.828026

Sayı

Yazarlar:

Mustafa YENERÇAĞ | Uğur ARSLAN | Metin ÇOKSEVİM | Seçkin DERELİ | Mustafa DOĞDUŞ | Güney ERDOĞAN

Yayıncı:

Alanya Alaaddin Keykubat University

Ana Başlıklar:

Hastalıklar

Dergi:

Acta Medica Alanya 2021 Vol.5 Issue 1, pp.66-74

Belge Tipi:

Makale

Yayın Tarihi:

4/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000439978

Sıklık:

Üç Yıllık

eISSN:

2587-0319

DOI:

https://doi.org/10.30565/medalanya.828026