SYSTEMIC IMMUNE INFLAMMATION INDEX AND PAN-IMMUNE INFLAMMATION VALUE IN PREDICTING HUMAN LEUKOCYTE ANTIGEN-B27 POSITIVITY: A STUDY ON ANKYLOSING SPONDYLITIS PATIENTS

Adem Keskin; Taner Karakaya; Recai Aci; Ozlem Sezer; Samet Semiz; Ferhat Şirinyıldız; İpek Okutan

Makale detayları

SYSTEMIC IMMUNE INFLAMMATION INDEX AND PAN-IMMUNE INFLAMMATION VALUE IN PREDICTING HUMAN LEUKOCYTE ANTIGEN-B27 POSITIVITY: A STUDY ON ANKYLOSING SPONDYLITIS PATIENTS

Yazarlar:

Adem Keskin | Taner Karakaya | Recai Aci | Ozlem Sezer | Samet Semiz | Ferhat Şirinyıldız | İpek Okutan

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.244-252

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327325

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Objective: Ankylosing spondylitis AS is defined as both an auto-immune and autoinflammatory illness. Human leukocyte antigen B27 HLA-B27, which is extensively employed in the diagnosis of chronic inflammatory diseases, is the basic laboratory parameter of axial spondylarthritis including AS. Systemic immune-inflammation index SII and pan-immune-inflammation value PIV, obtained by formulating complete blood count parameters, are promising biomarkers that reflect systemic inflammation and local immune response and predict prognosis in diseases. The aim of this study was to investigate the sensitivity and specificity of SII and PIV biomarkers in predicting HLA-B27 positivity in AS patients. Materials and Methods: The research included 68 individuals with HLA-B27 tests  AS group and 102 patients with HLA-B27 tests - control group. Results: In the AS group, lymphocyte and mean platelet volume values were determined to be lower than in the control group, while other complete blood count parameters, erythrocyte sedimentation rate ESR and C-reactive protein CRP, were found to be higher. While the SII and PIV values of the AS group determined a positive relation with CRP and ESR levels, they did not show a correlation in the control group. While the sensitivity for PIV in predicting HLA-B27 positivity was found to be 83.80 and the specificity was found to be 84.30, for SII the sensitivity was found to be 83.80 and the specificity was found to be 86.30. Conclusion: Easily and rapidly accessible biomarkers SII and PIV can potentially be used to predict HLA-B27 positivity in AS patients.

 Objective: Ankylosing spondylitis AS is defined as both an auto-immune and autoinflammatory illness. Human leukocyte antigen B27 HLA-B27, which is extensively employed in the diagnosis of chronic inflammatory diseases, is the basic laboratory parameter of axial spondylarthritis including AS. Systemic immune-inflammation index SII and pan-immune-inflammation value PIV, obtained by formulating complete blood count parameters, are promising biomarkers that reflect systemic inflammation and local immune response and predict prognosis in diseases. The aim of this study was to investigate the sensitivity and specificity of SII and PIV biomarkers in predicting HLA-B27 positivity in AS patients. Materials and Methods: The research included 68 individuals with HLA-B27 tests  AS group and 102 patients with HLA-B27 tests - control group. Results: In the AS group, lymphocyte and mean platelet volume values were determined to be lower than in the control group, while other complete blood count parameters, erythrocyte sedimentation rate ESR and C-reactive protein CRP, were found to be higher. While the SII and PIV values of the AS group determined a positive relation with CRP and ESR levels, they did not show a correlation in the control group. While the sensitivity for PIV in predicting HLA-B27 positivity was found to be 83.80 and the specificity was found to be 84.30, for SII the sensitivity was found to be 83.80 and the specificity was found to be 86.30. Conclusion: Easily and rapidly accessible biomarkers SII and PIV can potentially be used to predict HLA-B27 positivity in AS patients.

 Objective: Ankylosing spondylitis AS is defined as both an auto-immune and autoinflammatory illness. Human leukocyte antigen B27 HLA-B27, which is extensively employed in the diagnosis of chronic inflammatory diseases, is the basic laboratory parameter of axial spondylarthritis including AS. Systemic immune-inflammation index SII and pan-immune-inflammation value PIV, obtained by formulating complete blood count parameters, are promising biomarkers that reflect systemic inflammation and local immune response and predict prognosis in diseases. The aim of this study was to investigate the sensitivity and specificity of SII and PIV biomarkers in predicting HLA-B27 positivity in AS patients. Materials and Methods: The research included 68 individuals with HLA-B27 tests  AS group and 102 patients with HLA-B27 tests - control group. Results: In the AS group, lymphocyte and mean platelet volume values were determined to be lower than in the control group, while other complete blood count parameters, erythrocyte sedimentation rate ESR and C-reactive protein CRP, were found to be higher. While the SII and PIV values of the AS group determined a positive relation with CRP and ESR levels, they did not show a correlation in the control group. While the sensitivity for PIV in predicting HLA-B27 positivity was found to be 83.80 and the specificity was found to be 84.30, for SII the sensitivity was found to be 83.80 and the specificity was found to be 86.30. Conclusion: Easily and rapidly accessible biomarkers SII and PIV can potentially be used to predict HLA-B27 positivity in AS patients.

 Amaç: Ankilozan spondilit AS hem otoimmün hem de otoinflamatuar bir hastalık olarak tanımlanır. Kronik inflamatuar hastalıklarda tanı amaçlı yaygın olarak kullanılan insan lökosit antijeni B27 HLA-B27, AS dahil aksiyel spondiloartritin temel laboratuvar parametresidir. Tam kan sayımı parametrelerinin formüle edilmesiyle elde edilen sistemik immün-inflamasyon indeksi SII ve pan-immün-inflamasyon değeri PIV, sistemik inflamasyonu ve lokal immün yanıtı yansıtan ve hastalıklarda prognozu öngören umut verici biyobelirteçlerdir. Bu çalışmanın amacı, AS hastalarında HLA-B27 pozitifliğini öngörmede SII ve PIV biyobelirteçlerinin duyarlılığını ve özgüllüğünü araştırmaktır. Gereç ve Yöntemler: Çalışmaya HLA-B27 testleri pozitif olan 68 hasta AS grubu ve HLA-B27 testleri negatif olan 102 hasta kontrol grubu dahil edildi. Bulgular: AS grubunda lenfosit ve ortalama trombosit hacmi değerleri kontrol grubuna göre düşük bulunurken, diğer tam kan sayımı parametreleri, eritrosit sedimantasyon oranı ESR ve C-reaktif protein CRP daha yüksek bulundu. AS grubunun SII ve PIV değerleri CRP ve ESR düzeyleri ile pozitif korelasyon gösterirken, kontrol grubunda korelasyon göstermedi. HLA-B27 pozitifliğini öngörmede PIV için duyarlılık 83,80, özgüllük 84,30 bulunurken, SII için duyarlılık 83,80, özgüllük 86,30 bulundu. Sonuç: Kolayca ve hızla erişilebilen biyobelirteçler SII ve PIV, AS hastalarında HLA-B27 pozitifliğini tahmin etmek için potansiyel olarak kullanılabilir.

Makale detayları

SYSTEMIC IMMUNE INFLAMMATION INDEX AND PAN-IMMUNE INFLAMMATION VALUE IN PREDICTING HUMAN LEUKOCYTE ANTIGEN-B27 POSITIVITY: A STUDY ON ANKYLOSING SPONDYLITIS PATIENTS

Yazarlar:

Adem Keskin | Taner Karakaya | Recai Aci | Ozlem Sezer | Samet Semiz | Ferhat Şirinyıldız | İpek Okutan

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.244-252

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327325

pISSN:

2149-9063

PIV

Ankylosing Spondylitis

SII

Human leukocyte antigen-b27Ankilozan Spondilit

SII

PIV

İnsan lökosit antijeni-b27.

Sayı

Makale detayları

Yazarlar: Adem Keskin | Taner Karakaya | Recai Aci | Ozlem Sezer | Samet Semiz | Ferhat Şirinyıldız | İpek Okutan

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Biochemistry and Cell Biology (Other)

Dergi: Meandros Medical And Dental Journal Vol.25 Issue 3, pp.244-252

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001327325

pISSN: 2149-9063

Sayı

Yazarlar:

Adem Keskin | Taner Karakaya | Recai Aci | Ozlem Sezer | Samet Semiz | Ferhat Şirinyıldız | İpek Okutan

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.244-252

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327325

pISSN:

2149-9063