Synthesis of the Amide Derivatives of 3-[1-(3-Pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic Acids as Potential Analgesic Compounds

Erden BANOĞLU; Murat ŞÜKÜROĞLU; Burcu Çalişkan ERGÜN

Makale detayları

Synthesis of the Amide Derivatives of 3-[1-(3-Pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic Acids as Potential Analgesic Compounds

Yazarlar:

Erden BANOĞLU | Murat ŞÜKÜROĞLU | Burcu Çalişkan ERGÜN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 6, pp.677-687

Belge Tipi:

Makale

Yayın Tarihi:

5/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728613

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A series of structurally diverse amide derivatives of  3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic acids were  prepared and tested for their in vivo analgesic activity using an  acetic acid induced writhing test.  All the test compounds displayed  approximately equipotent analgesic activity to aspirin.  The results  showed that the analgesic activity of 5a, 5f, 5n, and 5o is  significantly higher than that of 5d.

 

A series of structurally diverse amide derivatives of  3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic acids were  prepared and tested for their in vivo analgesic activity using an  acetic acid induced writhing test.  All the test compounds displayed  approximately equipotent analgesic activity to aspirin.  The results  showed that the analgesic activity of 5a, 5f, 5n, and 5o is  significantly higher than that of 5d.

Makale detayları

Synthesis of the Amide Derivatives of 3-[1-(3-Pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic Acids as Potential Analgesic Compounds

Yazarlar: Erden BANOĞLU | Murat ŞÜKÜROĞLU | Burcu Çalişkan ERGÜN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 6, pp.677-687

Belge Tipi: Makale

Yayın Tarihi: 5/2007

Belge Dili: Türkçe

Document ID (Org No.): 2000728613

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Erden BANOĞLU | Murat ŞÜKÜROĞLU | Burcu Çalişkan ERGÜN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 6, pp.677-687

Belge Tipi:

Makale

Yayın Tarihi:

5/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728613

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527