Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Oruc Sahin; Emine Hande Kılıçaslan Şahin; Ersel Dağ

Makale detayları

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Yazarlar:

Oruc Sahin | Emine Hande Kılıçaslan Şahin | Ersel Dağ

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Duzce Medical Journal Vol.26 Issue 1, pp.56-63

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312883

pISSN:

1307-671X

Anahtar kelimeler:

Özet:

 Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis MS and investigate the association with magnetic resonance imaging MRI results. Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test RAVLT, line bisection test LBT, serial reaction time test SRTT, and finger tapping test FTT. The relationship between severity of disease, MRI, and test performance was investigated. Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left p0.024. On cognitive tests, there was no significant difference in Stroop test results p0.134, but the mean overall RAVLT of the patient group was significantly lower than that of the control group p0.001. Patients had significantly longer reaction times in SRTT p0.038. A positive correlation was found between the expanded disability status scale EDSS score and LBT results r0.326, p0.031, and a negative correlation between RAVLT results and EDSS score. For fine motor skills, a negative correlation was observed between FTT results and the number of MS plaques in the left hemisphere r-0.431, p0.045, and a positive correlation between the number of SRTT error and the number of plaques in the juxtacortical regions r0.461, p0.031. Conclusion: This study shows that the impairment of cognitive functions in MS disease is associated with both the course and severity of the disease and MRI findings.

 Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis MS and investigate the association with magnetic resonance imaging MRI results. Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test RAVLT, line bisection test LBT, serial reaction time test SRTT, and finger tapping test FTT. The relationship between severity of disease, MRI, and test performance was investigated. Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left p0.024. On cognitive tests, there was no significant difference in Stroop test results p0.134, but the mean overall RAVLT of the patient group was significantly lower than that of the control group p0.001. Patients had significantly longer reaction times in SRTT p0.038. A positive correlation was found between the expanded disability status scale EDSS score and LBT results r0.326, p0.031, and a negative correlation between RAVLT results and EDSS score. For fine motor skills, a negative correlation was observed between FTT results and the number of MS plaques in the left hemisphere r-0.431, p0.045, and a positive correlation between the number of SRTT error and the number of plaques in the juxtacortical regions r0.461, p0.031. Conclusion: This study shows that the impairment of cognitive functions in MS disease is associated with both the course and severity of the disease and MRI findings.

 Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis MS and investigate the association with magnetic resonance imaging MRI results. Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test RAVLT, line bisection test LBT, serial reaction time test SRTT, and finger tapping test FTT. The relationship between severity of disease, MRI, and test performance was investigated. Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left p0.024. On cognitive tests, there was no significant difference in Stroop test results p0.134, but the mean overall RAVLT of the patient group was significantly lower than that of the control group p0.001. Patients had significantly longer reaction times in SRTT p0.038. A positive correlation was found between the expanded disability status scale EDSS score and LBT results r0.326, p0.031, and a negative correlation between RAVLT results and EDSS score. For fine motor skills, a negative correlation was observed between FTT results and the number of MS plaques in the left hemisphere r-0.431, p0.045, and a positive correlation between the number of SRTT error and the number of plaques in the juxtacortical regions r0.461, p0.031. Conclusion: This study shows that the impairment of cognitive functions in MS disease is associated with both the course and severity of the disease and MRI findings.

 Amaç: Bu çalışmada multipl skleroz MS hastalarının bilişsel işlevleri ve ince motor becerilerinin gözden geçirilmesi ve bunların manyetik rezonans görüntüleme MRG sonuçları ile ilişkisinin araştırılması amaçlandı. Gereç ve Yöntemler: Çalışmaya relaps-remisyon tipi MS tanısı alan 22 hasta ve 22 kontrol grubu dahil edildi. Katılımcılara Stroop testi, Rey işitsel sözel öğrenme testi Rey auditory verbal learning test, RAVLT, çizgi bölme testi ÇBT, seri seçim reaksiyon testi SSRT ve parmak vuru testi PVT dahil olmak üzere nöropsikolojik testler uygulandı. Hastalık şiddeti ve MRG ile test performansı arasındaki ilişki de incelendi. Bulgular: Elde edilen sonuçlara göre ÇBT verilerinde hastaların sağa lateralize olduğu, kontrol grubunun ise sola lateralize olduğu tespit edildi p0,024. Bilişsel testlerde, Stroop testi sonuçları arasında anlamlı bir fark bulunmazken p0,134, hasta grubunun genel RAVLT ortalaması kontrol grubuna göre anlamlı derecede düşüktü p0,001. Hastaların SRTTdeki ortalama reaksiyon süresi anlamlı derecede daha uzundu p0,038. Genişletilmiş engellilik durumu ölçeği expanded disability status scale, EDSS skoru ile ÇBT sonuçları arasında pozitif bir korelasyon r0,326; p0,031 ve RAVLT sonuçları ile EDSS skoru arasında negatif bir korelasyon belirlendi. İnce motor becerilerde, sağ el PVT sonuçları ile sol hemisferdeki MS plağı sayısı arasında negatif bir korelasyon r-0,431; p0,045 ve SSRT hata sayısı ile jukstakortikal bölgelerdeki plak sayısı arasında pozitif bir korelasyon p0.031 tespit edildi. Sonuç: Bu çalışma, MS hastalığında bilişsel işlevlerdeki bozulmanın hem hastalığın seyri ve şiddetiyle hem de MR bulgularıyla ilişkili olduğunu göstermiştir.

Makale detayları

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Yazarlar:

Oruc Sahin | Emine Hande Kılıçaslan Şahin | Ersel Dağ

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Duzce Medical Journal Vol.26 Issue 1, pp.56-63

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312883

pISSN:

1307-671X

Multiple Sclerosis

Cognitive Functions

Neuroanatomical Localization

Fine Motor SkillsMultipl Skleroz

Bilişsel İşlevler

Nöroanatomik Lokalizasyon

İnce Motor Beceri

Sayı

Makale detayları

Yazarlar: Oruc Sahin | Emine Hande Kılıçaslan Şahin | Ersel Dağ

Yayıncı: Duzce University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Duzce Medical Journal Vol.26 Issue 1, pp.56-63

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312883

pISSN: 1307-671X

Sayı

Yazarlar:

Oruc Sahin | Emine Hande Kılıçaslan Şahin | Ersel Dağ

Yayıncı:

Duzce University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Duzce Medical Journal Vol.26 Issue 1, pp.56-63

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312883

pISSN:

1307-671X