Induction of oxidative/nitrosative stress following Tc-99m pertechnetate thyroid scintigraphy in human

Ebru SALMANOGLU; Ergul BELGE KURUTAS

doi:https://doi.org/10.7197/cmj.vi.486246

Makale detayları

Induction of oxidative/nitrosative stress following Tc-99m pertechnetate thyroid scintigraphy in human

Yazarlar:

Ebru SALMANOGLU | Ergul BELGE KURUTAS

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.592-598

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922504

DOI:

https://doi.org/10.7197/cmj.vi.486246

Özet:

 


Objective: Oxidative/nitrosative stress may be triggered by a
various sources and ionizing radiation may also initiate oxidative/nitrosative
stress. 


This is the first study, we aimed to investigate the
induction of oxidative and nitrosative stress due to ionizing radiation in
patients undergoing Tc-99m pertechnetate thyroid scintigraphy.


Method: Totally 26 patients (16 female,10 male) undergoing
Tc-99m pertechnetate thyroid scintigraphy were included in this study. The
patients were aged between 20 and  50
years (58.0±16.3 years). The blood samples were taken from patients  20 
minutes  after intravenous
injection of  Tc-99m pertechnetate  in dose used clinically (5 miliCurie) before
the patients were taken to the thyroid imaging. Control group was selected from
30 healthy subjects (15 female,15 male). The control group was aged between 17
and 72 years (57.0±14.0 years). The blood samples were taken both patients and
control group for measuring antioxidant enzymes (catalase and superoxide
dismutase), malondialdehyde, nitric oxide and nitrotyrosine as
oxidative/nitrosative stress biomarkers.  


Results: In this study we found that activities of antioxidant
enzymes inreased in patients compared to control (p<0.05). Further,
malondialdehyde levels as an indicator of oxidative stress were higher in
patients than control group (p<0.05).The levels of nitric oxide and
nitrotyrosine as nitrosative stress biomarkers also increased in patients
compared to control groups (p<0.05).   












Conclusions:
We
thought that Tc-99m pertechnetate may cause an increase in reactive oxygen and
nitrogen species and may cause oxidative/nitrosative damage at the cellular
level. Our results indicated that the dose of Tc-99m pertechnetate given in
these patients undergoing thyroid scintigraphy can tolerable.


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Makale detayları

Induction of oxidative/nitrosative stress following Tc-99m pertechnetate thyroid scintigraphy in human

Yazarlar: Ebru SALMANOGLU | Ergul BELGE KURUTAS

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.592-598

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000922504

DOI: https://doi.org/10.7197/cmj.vi.486246

Sayı

Yazarlar:

Ebru SALMANOGLU | Ergul BELGE KURUTAS

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.592-598

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922504

DOI:

https://doi.org/10.7197/cmj.vi.486246