Hepatitis C Virus: Genome Organization, Viral  Proteins and Implications in Disease Pathogenesis

Çağla EROĞLU; Ergün PINARBAŞI

Makale detayları

Hepatitis C Virus: Genome Organization, Viral Proteins and Implications in Disease Pathogenesis

Yazarlar:

Çağla EROĞLU | Ergün PINARBAŞI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2000 Vol.24 Issue 2, pp.253-270

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000814069

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

The hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality  worldwide. Infection with HCV becomes chronic in more than 80% of cases and it accounts for 20%  of all cases of acute hepatitis. The hepatitis C virus was first identified by the molecular cloning of the  virus genome in 1989. It is an enveloped, positive strand RNA virus with a genome size of around 9.5  kilobases. The single-stranded RNA genome of the virus contains a large open reading frame that  encodes a large polyprotein of 3,010 to 3,033 amino acids shown to be processed by a combination  of host and viral proteinases to produce at least ten proteins post-translationally. The proteins that are  closer to the amino terminal of the polyprotein are termed structural and the rest, closer to the  carboxy terminal, are called nonstructural (NS) proteins.

 

The hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality  worldwide. Infection with HCV becomes chronic in more than 80% of cases and it accounts for 20%  of all cases of acute hepatitis. The hepatitis C virus was first identified by the molecular cloning of the  virus genome in 1989. It is an enveloped, positive strand RNA virus with a genome size of around 9.5  kilobases. The single-stranded RNA genome of the virus contains a large open reading frame that  encodes a large polyprotein of 3,010 to 3,033 amino acids shown to be processed by a combination  of host and viral proteinases to produce at least ten proteins post-translationally. The proteins that are  closer to the amino terminal of the polyprotein are termed structural and the rest, closer to the  carboxy terminal, are called nonstructural (NS) proteins.

Makale detayları

Hepatitis C Virus: Genome Organization, Viral Proteins and Implications in Disease Pathogenesis

Yazarlar:

Çağla EROĞLU | Ergün PINARBAŞI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2000 Vol.24 Issue 2, pp.253-270

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000814069

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Turk. J. Biol.

24

(2000)

253-270. Full text: pdf Other articles published in the same issue: Turk. J. Biol.

vol.24

iss.2.

Sayı

Makale detayları

Hepatitis C Virus: Genome Organization, Viral Proteins and Implications in Disease Pathogenesis

Yazarlar: Çağla EROĞLU | Ergün PINARBAŞI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2000 Vol.24 Issue 2, pp.253-270

Belge Tipi: Makale

Yayın Tarihi: 1/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000814069

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Turk. J. Biol.

24

(2000)

253-270. Full text: pdf Other articles published in the same issue: Turk. J. Biol.

vol.24

iss.2.

Sayı

Yazarlar:

Çağla EROĞLU | Ergün PINARBAŞI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2000 Vol.24 Issue 2, pp.253-270

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000814069

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152