Prevalence and resistance trends of Gram positive cocci Staphylococcus aereus and Enterococcus spp. in a tertiary care hospital

Hatice Hale Gümüş

Makale detayları

Prevalence and resistance trends of Gram positive cocci Staphylococcus aereus and Enterococcus spp. in a tertiary care hospital

Yazarlar:

Hatice Hale Gümüş

Yayıncı:

Cukurova University

Ana Başlıklar:

Bulaşıcı Hastalıklar | Klinik Mikrobiyoloji | Tıbbi Bakteriyoloji | Tıbbi Enfeksiyon Ajanları

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1177-1186

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286416

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Antimicrobial resistance is a silent pandemic. In this study, it was aimed to determine the distribution and resistance trends of Staphylococcus aureus S. aureus, Enterococcus faecium E. faecium and Enterococcus faecalis E. faecalis isolates, which are among the priority pathogens of the World Health Organization in bloodstream infections. Materials and Methods: This was a retrospective study conducted between January 1, 2021 and March 31, 2023. The blood cultures n1261, of which microbiologically tested by using an automated system, were screened in the relevant period via laboratory information system. Results: Of the total 941 isolates, 51.9 were S. aureus n488, 22.9 were E. faecalis n216, and 25.2 were E. faecium n237. Of the patients, 89.1 were inpatients n838, and 10.9 were outpatients n103. The most of patients were hospitalized in internal medicine departments 53.3 and in intensive care units 35. Among S. aureus isolates, the resistance rate to benzylpenicillin was 93.8, to methicillin 44.3, to teicoplanin 3.7, and to linezolid 0.4. Vancomycin and tigecycline resistances were not detected. Of the E. faecalis isolates, 5.5 were resistant to ampicillin, 3.3 to vancomycin, 3.2 to linezolid, and 0.7 to tigecycline. The resistance rates for E. faecium strains were 90.9 for ampicillin, 28.7 for vancomycin, 17.7 for tigecycline, 4.3 for linezolid, and 0.8 for teicoplanin. When the susceptibilities of all three bacteria were compared, a statistically significant difference was found between teicoplanin, vancomycin, tigecycline and linezolid susceptibilities. The methicillin resistance was higher in internal medicine and intensive care units. The levofloxacin and vancomycin resistance were more prevalent in intensive care units. Conclusion: MRSA 44.3, vancomycin 28.7 and tigecycline 17.7 resistant E. faecium rates are well above the national data. The epidemiology on resistance trends, which will guide clinicians in the management of bloodstream infections, should be carried out periodically.

 Purpose: Antimicrobial resistance is a silent pandemic. In this study, it was aimed to determine the distribution and resistance trends of Staphylococcus aureus S. aureus, Enterococcus faecium E. faecium and Enterococcus faecalis E. faecalis isolates, which are among the priority pathogens of the World Health Organization in bloodstream infections. Materials and Methods: This was a retrospective study conducted between January 1, 2021 and March 31, 2023. The blood cultures n1261, of which microbiologically tested by using an automated system, were screened in the relevant period via laboratory information system. Results: Of the total 941 isolates, 51.9 were S. aureus n488, 22.9 were E. faecalis n216, and 25.2 were E. faecium n237. Of the patients, 89.1 were inpatients n838, and 10.9 were outpatients n103. The most of patients were hospitalized in internal medicine departments 53.3 and in intensive care units 35. Among S. aureus isolates, the resistance rate to benzylpenicillin was 93.8, to methicillin 44.3, to teicoplanin 3.7, and to linezolid 0.4. Vancomycin and tigecycline resistances were not detected. Of the E. faecalis isolates, 5.5 were resistant to ampicillin, 3.3 to vancomycin, 3.2 to linezolid, and 0.7 to tigecycline. The resistance rates for E. faecium strains were 90.9 for ampicillin, 28.7 for vancomycin, 17.7 for tigecycline, 4.3 for linezolid, and 0.8 for teicoplanin. When the susceptibilities of all three bacteria were compared, a statistically significant difference was found between teicoplanin, vancomycin, tigecycline and linezolid susceptibilities. The methicillin resistance was higher in internal medicine and intensive care units. The levofloxacin and vancomycin resistance were more prevalent in intensive care units. Conclusion: MRSA 44.3, vancomycin 28.7 and tigecycline 17.7 resistant E. faecium rates are well above the national data. The epidemiology on resistance trends, which will guide clinicians in the management of bloodstream infections, should be carried out periodically.

 Purpose: Antimicrobial resistance is a silent pandemic. In this study, it was aimed to determine the distribution and resistance trends of Staphylococcus aureus S. aureus, Enterococcus faecium E. faecium and Enterococcus faecalis E. faecalis isolates, which are among the priority pathogens of the World Health Organization in bloodstream infections. Materials and Methods: This was a retrospective study conducted between January 1, 2021 and March 31, 2023. The blood cultures n1261, of which microbiologically tested by using an automated system, were screened in the relevant period via laboratory information system. Results: Of the total 941 isolates, 51.9 were S. aureus n488, 22.9 were E. faecalis n216, and 25.2 were E. faecium n237. Of the patients, 89.1 were inpatients n838, and 10.9 were outpatients n103. The most of patients were hospitalized in internal medicine departments 53.3 and in intensive care units 35. Among S. aureus isolates, the resistance rate to benzylpenicillin was 93.8, to methicillin 44.3, to teicoplanin 3.7, and to linezolid 0.4. Vancomycin and tigecycline resistances were not detected. Of the E. faecalis isolates, 5.5 were resistant to ampicillin, 3.3 to vancomycin, 3.2 to linezolid, and 0.7 to tigecycline. The resistance rates for E. faecium strains were 90.9 for ampicillin, 28.7 for vancomycin, 17.7 for tigecycline, 4.3 for linezolid, and 0.8 for teicoplanin. When the susceptibilities of all three bacteria were compared, a statistically significant difference was found between teicoplanin, vancomycin, tigecycline and linezolid susceptibilities. The methicillin resistance was higher in internal medicine and intensive care units. The levofloxacin and vancomycin resistance were more prevalent in intensive care units. Conclusion: MRSA 44.3, vancomycin 28.7 and tigecycline 17.7 resistant E. faecium rates are well above the national data. The epidemiology on resistance trends, which will guide clinicians in the management of bloodstream infections, should be carried out periodically.

 Amaç: Antimikrobiyal direnç sessiz bir salgındır. Bu çalışmada Dünya Sağlık Örgütünün kan dolaşımı enfeksiyonlarında öncelikli patojenler arasında yer verdiği Staphylococcus aureus S. aureus, Enterococcus faecium E. faecium ve Enterococcus faecalis E. faecalis izolatlarının dağılımı ve direnç eğilimlerinin belirlenmesi amaçlandı. Gereç ve Yöntem: Retrospektif olan bu çalışma, 1 Ocak 2021 ile 31 Mart 2023 tarihleri arasında gerçekleştirildi. Otomatik sistem kullanılarak mikrobiyolojik incelemesi yapılan kan kültürleri n1261 ilgili dönemde laboratuvarı bilgi sistemi ile tarandı. Bulgular: Çalışmaya dahil edilen toplam 941 izolatın 51.9u S. aureus n488, 22.9u E. faecalis n216 ve 25.2si E. faecium n237 idi. Hastaların 89.1i yatan n838, 10.9u ayaktan n103 hastalardı. Hastaların büyük çoğunluğu dahili servislerde 53.3 ve yoğun bakım ünitelerinde 35 yatmaktaydı. S. aureus izolatlarında benzilpenisiline direnç oranı 93.8, metisiline 44.3, teikoplanine 3.7 ve linezolide 0.4 direnç gösterdi. Vankomisin ve tigesiklin direnci saptanmadı. E. faecalis izolatlarının 5.5inin ampisiline, 3.3ünün vankomisine, 3.2sinin linezolide ve 0.7sinin tigesikline dirençli olduğu belirlendi. E. faecium suşlarında direnç oranları ampisilin için 90.9, vankomisin için 28.7, tigesiklin için 17.7, linezolid için 4.3 ve teikoplanin için 0.8 olarak belirlendi. Her üç bakterinin duyarlılıkları karşılaştırıldığında, teikoplanin, vankomisin, tigesiklin ve linezolid duyarlılıkları arasında istatistiksel olarak anlamlı farklılık bulunduğu saptandı. Metisilin direnci dahiliye ve yoğun bakım ünitelerinde daha yüksekti. Levofloksasin ve vankomisin direnci yoğun bakım ünitelerinde daha yaygındı. Sonuç: Metisiline dirençli S. aureus 44.3, vankomisin 28.7 ve tigesikline 17.7 dirençli E. faecium oranları ulusal verilerin oldukça üzerindedir. Kan dolaşımı enfeksiyonlarının tedavisinde klinisyenlere yol gösterecek direnç eğilimlerine ilişkin epidemiyolojik çalışmaların periyodik olarak yapılması gerekmektedir.

Makale detayları

Prevalence and resistance trends of Gram positive cocci Staphylococcus aereus and Enterococcus spp. in a tertiary care hospital

Yazarlar:

Hatice Hale Gümüş

Yayıncı:

Cukurova University

Ana Başlıklar:

Bulaşıcı Hastalıklar | Klinik Mikrobiyoloji | Tıbbi Bakteriyoloji | Tıbbi Enfeksiyon Ajanları

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1177-1186

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286416

pISSN:

2602-3032

Enterococcus faecium

Enterococcus faecalis

antimicrobial resistance

methicillin resistance

vancomycin resistance

linezolid resistance

tigecycline resistance

MRSA

VRSA

VRE

Enterococcus faecium

Enterococcus faecalis

antimikrobiyal direnç

metisilin direnci

vankomisin direnci

linezolid direnci

tigesiklin direnci

MRSA

VRSA

VRE.

Sayı

Makale detayları

Yazarlar: Hatice Hale Gümüş

Yayıncı: Cukurova University

Ana Başlıklar: Bulaşıcı Hastalıklar | Klinik Mikrobiyoloji | Tıbbi Bakteriyoloji | Tıbbi Enfeksiyon Ajanları

Dergi: Cukurova Medical Journal Vol.48 Issue 3, pp.1177-1186

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286416

pISSN: 2602-3032

Sayı

Yazarlar:

Hatice Hale Gümüş

Yayıncı:

Cukurova University

Ana Başlıklar:

Bulaşıcı Hastalıklar | Klinik Mikrobiyoloji | Tıbbi Bakteriyoloji | Tıbbi Enfeksiyon Ajanları

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1177-1186

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286416

pISSN:

2602-3032