Evaluation of arterial stiffness in patients with generalized anxiety disorder

Burcu Sırlıer Emir; Sevler Yıldız; Aslı Kazğan Kılıçaslan; Kerim Uğur; Osman Kurt

Makale detayları

Evaluation of arterial stiffness in patients with generalized anxiety disorder

Yazarlar:

Burcu Sırlıer Emir | Sevler Yıldız | Aslı Kazğan Kılıçaslan | Kerim Uğur | Osman Kurt

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.385-393

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286342

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Generalized anxiety disorder GAD is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness IMT and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.

 Purpose: Generalized anxiety disorder GAD is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness IMT and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.

 Purpose: Generalized anxiety disorder GAD is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness IMT and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.

 Amaç: Yaygın anksiyete bozukluğu YAB sempatik sistemin aktive olmasıyla birlikte bedensel ve ruhsal belirtilerin bir arada görüldüğü psikiyatrik hastalıktır. Bu hastalıkta kardiyovasküler sistemin etkilendiği bilinmektedir. Bu çalışmada YAB tanılı hastalarda arter sertliğini değerlendirmeyi ve sağlıklı kontrollerle kıyaslamayı amaçladık. Gereç ve Yöntem: YAB tanısı almış 40 hasta ve 40 sağlıklı birey çalışmaya dahil edildi. Karotis ve femoral arter intima-medial kalınlığı IMT ve arteriyel kalınlık parametreleri doppler ultrasonografi ile ölçüldü. Bulgular: Hastaların femoral IMT değeri anlamlı şekilde düşük bulunmuştur. Hastalarda carotid IMT değeri ise sağlıklılardan daha kalın olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Fluoksetin eş değer dozu ile femoral IMT arasında negatif yönde anlamlı bir korelasyon belirlenmiştir. Femoral IMT ile fluoksetin eş değer dozu arasında ilişki olduğu görülmüştür. Sonuç: Arteriyel sertlik YAB da kardiyovasküler riski gösterebilme potansiyeli açısından araştırılmalıdır. Ateroskleroz belirtilerinin YAB hastalığının doğası gereği mi yoksa kullanılan ilaçlarla ilişkili mi olduğunu netleştirebilmek için daha geniş kapsamlı çalışmalara ihtiyaç bulunmaktadır.

Makale detayları

Evaluation of arterial stiffness in patients with generalized anxiety disorder

Yazarlar:

Burcu Sırlıer Emir | Sevler Yıldız | Aslı Kazğan Kılıçaslan | Kerim Uğur | Osman Kurt

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.385-393

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286342

pISSN:

2602-3032

Arterial stiffness

generalized anxiety disorder

cardiovascular risk

intima–media thickness.

Arteriyrl sertlik

yaygın anksiyete bozukluğu

kardiyovasküler risk

intima–media kalınlığı

Sayı

Makale detayları

Yazarlar: Burcu Sırlıer Emir | Sevler Yıldız | Aslı Kazğan Kılıçaslan | Kerim Uğur | Osman Kurt

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Cukurova Medical Journal Vol.48 Issue 2, pp.385-393

Belge Tipi: Makale

Yayın Tarihi: 2/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286342

pISSN: 2602-3032

Sayı

Yazarlar:

Burcu Sırlıer Emir | Sevler Yıldız | Aslı Kazğan Kılıçaslan | Kerim Uğur | Osman Kurt

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.385-393

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286342

pISSN:

2602-3032