EVALUATION OF THE EFFECT OF SCIATIC NERVE BLOCK ON POSTOPERATIVE ANALGESIA AND INFLAMMATORY RESPONSE IN KNEE ARTHROPLASTY

Orhun Demir; Bilal Atilla Bezen; Tuba Berra Sarıtaş; Özal Özcan; Halit Buğra Koca

Makale detayları

EVALUATION OF THE EFFECT OF SCIATIC NERVE BLOCK ON POSTOPERATIVE ANALGESIA AND INFLAMMATORY RESPONSE IN KNEE ARTHROPLASTY

Yazarlar:

Orhun Demir | Bilal Atilla Bezen | Tuba Berra Sarıtaş | Özal Özcan | Halit Buğra Koca

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 3, pp.249-254

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358218

pISSN:

2146-4006

Anahtar kelimeler:

Özet:

 Aim: Postoperative pain significantly impact on the recovery and hospitalization following orthopedic surgeries. The aim of the study was to investigate the effects of sciatic nerve block together with to femoral nerve block on the inﬂammatory response and postoperative pain control in single knee joint arthroplasties TKA. Material and Methods: The study was carried out at Afyonkarahisar Health Sciences University Hospital. The patients with ASA I-III patients aged 40-80 years undergoing elective unilateral TKA were enrolled. Participants were randomly assigned into two groups: Group I received both femoral and sciatic nerve blocks, while Group II received only a femoral nerve block. Postoperative pain was assessed using the Visual Analog Scale VAS at 2, 4, 8, 12, and 24 hours. Inflammatory markers TNF-alpha, IL-6, IL-8, and IL-10 were measured preoperatively and at 24 hours post-surgery. The results were compared between the groups. Results: 45 patients were enrolled to the study 22 in Group I and 23 in Group II. Group I exhibited significantly lower VAS scores at rest and during movement within the first 12 hours compared to Group II p0.05. The first analgesic requirement occurred earlier in Group I p0.001. Although cytokine levels increased in both groups, the rise was less pronounced in Group I, suggesting a potential reduction in the inflammatory response associated with the combined nerve block technique p0.05. No significant differences in opioid-related side effects were noted between the groups p0,04. Conclusion: This study shows that the addition of a sciatic nerve block to a femoral nerve block effectively enhances postoperative pain management and may attenuate the inflammatory response in TKA patients.

 Aim: Postoperative pain significantly impact on the recovery and hospitalization following orthopedic surgeries. The aim of the study was to investigate the effects of sciatic nerve block together with to femoral nerve block on the inﬂammatory response and postoperative pain control in single knee joint arthroplasties TKA. Material and Methods: The study was carried out at Afyonkarahisar Health Sciences University Hospital. The patients with ASA I-III patients aged 40-80 years undergoing elective unilateral TKA were enrolled. Participants were randomly assigned into two groups: Group I received both femoral and sciatic nerve blocks, while Group II received only a femoral nerve block. Postoperative pain was assessed using the Visual Analog Scale VAS at 2, 4, 8, 12, and 24 hours. Inflammatory markers TNF-alpha, IL-6, IL-8, and IL-10 were measured preoperatively and at 24 hours post-surgery. The results were compared between the groups. Results: 45 patients were enrolled to the study 22 in Group I and 23 in Group II. Group I exhibited significantly lower VAS scores at rest and during movement within the first 12 hours compared to Group II p0.05. The first analgesic requirement occurred earlier in Group I p0.001. Although cytokine levels increased in both groups, the rise was less pronounced in Group I, suggesting a potential reduction in the inflammatory response associated with the combined nerve block technique p0.05. No significant differences in opioid-related side effects were noted between the groups p0,04. Conclusion: This study shows that the addition of a sciatic nerve block to a femoral nerve block effectively enhances postoperative pain management and may attenuate the inflammatory response in TKA patients.

 Aim: Postoperative pain significantly impact on the recovery and hospitalization following orthopedic surgeries. The aim of the study was to investigate the effects of sciatic nerve block together with to femoral nerve block on the inﬂammatory response and postoperative pain control in single knee joint arthroplasties TKA. Material and Methods: The study was carried out at Afyonkarahisar Health Sciences University Hospital. The patients with ASA I-III patients aged 40-80 years undergoing elective unilateral TKA were enrolled. Participants were randomly assigned into two groups: Group I received both femoral and sciatic nerve blocks, while Group II received only a femoral nerve block. Postoperative pain was assessed using the Visual Analog Scale VAS at 2, 4, 8, 12, and 24 hours. Inflammatory markers TNF-alpha, IL-6, IL-8, and IL-10 were measured preoperatively and at 24 hours post-surgery. The results were compared between the groups. Results: 45 patients were enrolled to the study 22 in Group I and 23 in Group II. Group I exhibited significantly lower VAS scores at rest and during movement within the first 12 hours compared to Group II p0.05. The first analgesic requirement occurred earlier in Group I p0.001. Although cytokine levels increased in both groups, the rise was less pronounced in Group I, suggesting a potential reduction in the inflammatory response associated with the combined nerve block technique p0.05. No significant differences in opioid-related side effects were noted between the groups p0,04. Conclusion: This study shows that the addition of a sciatic nerve block to a femoral nerve block effectively enhances postoperative pain management and may attenuate the inflammatory response in TKA patients.

 Amaç: Postoperatif ağrı, ortopedik ameliyatlardan sonra iyileşme ve hastaneye yatış üzerinde önemli bir etkiye sahiptir. Çalışmanın amacı, tek diz eklemi artroplastilerinde TDA femoral sinir bloğu ile birlikte uygulanan siyatik sinir bloğunun inflamatuar yanıt ve ameliyat sonrası ağrı kontrolü üzerindeki etkilerini araştırmaktır. Gereç ve Yöntemler: Çalışma Afyonkarahisar Sağlık Bilimleri Üniversitesi Hastanesinde gerçekleştirildi. Elektif TDA geçiren 40-80 yaş aralığındaki ASA I-III hastalar çalışmaya dahil edildi. Katılımcılar rastgele iki gruba ayrıldı: Grup Ie hem femoral hem de siyatik sinir bloğu uygulanırken, Grup IIye sadece femoral sinir bloğu uygulandı. Ameliyat sonrası ağrı, Görsel Analog Skala VAS kullanılarak 2, 4, 8, 12 ve 24. saatlerde değerlendirildi. İnflamatuar belirteçler TNF-alfa, IL-6, IL-8 ve IL-10 ameliyat öncesi ve ameliyattan 24 saat sonra ölçüldü. Sonuçlar gruplar arasında karşılaştırıldı. Sonuçlar: Çalışmaya 45 hasta dahil edildi Grup-Ide 22 ve Grup-IIde 23. Grup-I, ilk 12 saat içinde dinlenme ve hareket sırasında Grup-IIye kıyasla önemli ölçüde daha düşük VAS skorları gösterdi p0.05. İlk analjezik gereksinimi Grup-Ide daha erken gerçekleşti p0.001. Her iki grupta da sitokin seviyeleri artmasına rağmen, artış Grup-Ide daha az belirgindi ve bu da kombine sinir bloğu tekniğiyle ilişkili inflamatuar yanıtta potansiyel bir azalma olduğunu düşündürmektedir p0.05. Gruplar arasında opioid ile ilişkili yan etkilerde önemli bir fark görülmedi p0.04. Sonuç: Bu çalışma, femoral sinir bloğuna siyatik sinir bloğu eklenmesinin, ameliyat sonrası ağrı yönetimini etkili bir şekilde iyileştirdiğini ve TKA hastalarında inflamatuar yanıtı hafifletebileceğini göstermektedir.

Makale detayları

EVALUATION OF THE EFFECT OF SCIATIC NERVE BLOCK ON POSTOPERATIVE ANALGESIA AND INFLAMMATORY RESPONSE IN KNEE ARTHROPLASTY

Yazarlar:

Orhun Demir | Bilal Atilla Bezen | Tuba Berra Sarıtaş | Özal Özcan | Halit Buğra Koca

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 3, pp.249-254

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358218

pISSN:

2146-4006

Sciatic nerve block

Femoral nerve block

Total knee arthroplasty

Postoperative pain

Postoperative inflammationSiyatik sinir bloğu

Femoral sinir bloğu

Postoperatif ağrı

Postoperatif inflamasyon

total diz artroplastisi

Sayı

Makale detayları

Yazarlar: Orhun Demir | Bilal Atilla Bezen | Tuba Berra Sarıtaş | Özal Özcan | Halit Buğra Koca

Yayıncı: Yozgat Bozok University

Ana Başlıklar: Anesteziyoloji

Dergi: Bozok Tıp Dergisi Vol.15 Issue 3, pp.249-254

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001358218

pISSN: 2146-4006

Sayı

Yazarlar:

Orhun Demir | Bilal Atilla Bezen | Tuba Berra Sarıtaş | Özal Özcan | Halit Buğra Koca

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 3, pp.249-254

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358218

pISSN:

2146-4006