The relationship between serum uric acid levels and severity of addiction in individuals with substance use disorders

Çetin Turan; Süheyla Ünal

Makale detayları

The relationship between serum uric acid levels and severity of addiction in individuals with substance use disorders

Yazarlar:

Çetin Turan | Süheyla Ünal

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Psychiatry

Dergi:

The European Research Journal Vol.9 Issue 4, pp.792-799

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287593

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: The aim of this study was to compare serum uric acid levels in patients with methamphetamine and synthetic cannabinoid use disorders pre- and post-detoxification treatment with healthy controls. Secondly, to determine the relationship between the serum uric acid levels of the cases and the severity of the addiction. Methods: Fifty methamphetamine, 50 synthetic cannabinoids, and 40 healthy controls were evaluated on the specified dates. Venous blood samples were taken from the participants to measure serum uric acid and creatinine levels. The arrangement was made by taking the Uric acidcreatinine ratio to neutralize the confounding effect of kidney functions. The Addiction Profile Index was applied to determine the severity of substance abuse in the case group. Results: A statistically significant difference was found between the uric acid values of all three groups when the One-way ANOVA test was performed  p  0.001. UA values were significantly lower in the case groups than in the healthy control group. When the substance use characteristics of the case groups were compared, a statistically significant difference was found in the duration of substance use  p  0.010 and motivation  p  0.031 subtests. Duration of substance use and craving were higher in the synthetic substance group, and motivation was higher in the methamphetamine group. According to the Pearson analysis, the severity of addiction was deduced not to be correlated with serum uric acid and uric acidcreatinine levels in both case groups. Conclusions: Serum uric acid and uric acidcreatinine levels were found to be statistically significantly lower in individuals with methamphetamine and synthetic cannabinoid exposure compared to healthy controls. In this study, it was thought that the lower uric acid levels in the case group compared to the control group may be due to the use of uric acid as an antioxidant or a decrease in purinergic transformation. Future studies may focus on making this distinction.

 Objectives: The aim of this study was to compare serum uric acid levels in patients with methamphetamine and synthetic cannabinoid use disorders pre- and post-detoxification treatment with healthy controls. Secondly, to determine the relationship between the serum uric acid levels of the cases and the severity of the addiction. Methods: Fifty methamphetamine, 50 synthetic cannabinoids, and 40 healthy controls were evaluated on the specified dates. Venous blood samples were taken from the participants to measure serum uric acid and creatinine levels. The arrangement was made by taking the Uric acidcreatinine ratio to neutralize the confounding effect of kidney functions. The Addiction Profile Index was applied to determine the severity of substance abuse in the case group. Results: A statistically significant difference was found between the uric acid values of all three groups when the One-way ANOVA test was performed  p  0.001. UA values were significantly lower in the case groups than in the healthy control group. When the substance use characteristics of the case groups were compared, a statistically significant difference was found in the duration of substance use  p  0.010 and motivation  p  0.031 subtests. Duration of substance use and craving were higher in the synthetic substance group, and motivation was higher in the methamphetamine group. According to the Pearson analysis, the severity of addiction was deduced not to be correlated with serum uric acid and uric acidcreatinine levels in both case groups. Conclusions: Serum uric acid and uric acidcreatinine levels were found to be statistically significantly lower in individuals with methamphetamine and synthetic cannabinoid exposure compared to healthy controls. In this study, it was thought that the lower uric acid levels in the case group compared to the control group may be due to the use of uric acid as an antioxidant or a decrease in purinergic transformation. Future studies may focus on making this distinction.

 Objectives: The aim of this study was to compare serum uric acid levels in patients with methamphetamine and synthetic cannabinoid use disorders pre- and post-detoxification treatment with healthy controls. Secondly, to determine the relationship between the serum uric acid levels of the cases and the severity of the addiction. Methods: Fifty methamphetamine, 50 synthetic cannabinoids, and 40 healthy controls were evaluated on the specified dates. Venous blood samples were taken from the participants to measure serum uric acid and creatinine levels. The arrangement was made by taking the Uric acidcreatinine ratio to neutralize the confounding effect of kidney functions. The Addiction Profile Index was applied to determine the severity of substance abuse in the case group. Results: A statistically significant difference was found between the uric acid values of all three groups when the One-way ANOVA test was performed  p  0.001. UA values were significantly lower in the case groups than in the healthy control group. When the substance use characteristics of the case groups were compared, a statistically significant difference was found in the duration of substance use  p  0.010 and motivation  p  0.031 subtests. Duration of substance use and craving were higher in the synthetic substance group, and motivation was higher in the methamphetamine group. According to the Pearson analysis, the severity of addiction was deduced not to be correlated with serum uric acid and uric acidcreatinine levels in both case groups. Conclusions: Serum uric acid and uric acidcreatinine levels were found to be statistically significantly lower in individuals with methamphetamine and synthetic cannabinoid exposure compared to healthy controls. In this study, it was thought that the lower uric acid levels in the case group compared to the control group may be due to the use of uric acid as an antioxidant or a decrease in purinergic transformation. Future studies may focus on making this distinction.

 Objectives: The aim of this study was to compare serum uric acid levels in patients with methamphetamine and synthetic cannabinoid use disorders pre- and post-detoxification treatment with healthy controls. Secondly, to determine the relationship between the serum uric acid levels of the cases and the severity of the addiction. Methods: Fifty methamphetamine, 50 synthetic cannabinoids, and 40 healthy controls were evaluated on the specified dates. Venous blood samples were taken from the participants to measure serum uric acid and creatinine levels. The arrangement was made by taking the Uric acidcreatinine ratio to neutralize the confounding effect of kidney functions. The Addiction Profile Index was applied to determine the severity of substance abuse in the case group. Results: A statistically significant difference was found between the uric acid values of all three groups when the One-way ANOVA test was performed  p  0.001. UA values were significantly lower in the case groups than in the healthy control group. When the substance use characteristics of the case groups were compared, a statistically significant difference was found in the duration of substance use  p  0.010 and motivation  p  0.031 subtests. Duration of substance use and craving were higher in the synthetic substance group, and motivation was higher in the methamphetamine group. According to the Pearson analysis, the severity of addiction was deduced not to be correlated with serum uric acid and uric acidcreatinine levels in both case groups. Conclusions: Serum uric acid and uric acidcreatinine levels were found to be statistically significantly lower in individuals with methamphetamine and synthetic cannabinoid exposure compared to healthy controls. In this study, it was thought that the lower uric acid levels in the case group compared to the control group may be due to the use of uric acid as an antioxidant or a decrease in purinergic transformation. Future studies may focus on making this distinction.

Makale detayları

The relationship between serum uric acid levels and severity of addiction in individuals with substance use disorders

Yazarlar:

Çetin Turan | Süheyla Ünal

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Psychiatry

Dergi:

The European Research Journal Vol.9 Issue 4, pp.792-799

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287593

pISSN:

2149-3189

Methamphetamine

synthetic cannabinoid

uric acid

severity of addiction

Sayı

Makale detayları

The relationship between serum uric acid levels and severity of addiction in individuals with substance use disorders

Yazarlar: Çetin Turan | Süheyla Ünal

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Psychiatry

Dergi: The European Research Journal Vol.9 Issue 4, pp.792-799

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001287593

pISSN: 2149-3189

Methamphetamine

synthetic cannabinoid

uric acid

severity of addiction

Sayı

Yazarlar:

Çetin Turan | Süheyla Ünal

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Psychiatry

Dergi:

The European Research Journal Vol.9 Issue 4, pp.792-799

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287593

pISSN:

2149-3189