Factors Affecting Arterial Stiffness Level in Cancer Patients Receiving Immunotherapy

Esra Güner; Merve Bıyıklı Alemdar; Bilgin Demir; Merve Turan; Esin Oktay

Makale detayları

Factors Affecting Arterial Stiffness Level in Cancer Patients Receiving Immunotherapy

Yazarlar:

Esra Güner | Merve Bıyıklı Alemdar | Bilgin Demir | Merve Turan | Esin Oktay

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.101-107

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342929

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Aim: This study aimed of our study is to investigate the factors affecting the level of arterial stiffness in cancer patients receiving immunotherapy. Materials and Methods: The height, weight, BMI, age, gender, type of cancer, previous cancer treatment, agents used in the treatment, current immunotherapy agents, comorbid conditions, smoking history of 42 patients diagnosed with renal cell carcinoma RCC, lung cancer, malignant melanoma and receiving immunotherapy treatment were recorded at the time of their first application and their arterial stiffness levels were measured. Following the first measurement, the patients were seen again in the third and sixth therapy cycles and their measurements were repeated and recorded. Factors affecting the arterial stiffness level of the patients were evaluated. Results: It was observed that pulse wave velocity NWV increased with increasing age p0.01. No significant difference was found between cancer type and PWV; however, patients with lung cancer had higher pulse pressure at the first measurement than other patients. No significant difference was found between immunotherapy agents and PWV. PWV was found to be significantly higher in those with concomitant diseases p0.005. Pulse pressure was found to be higher in smokers than in non-smokers p0.007. Conclusion: It was concluded that smoking, gender and cancer type were effective in the change of pulse pressure in cancer patients receiving immunotherapy, that there was no significant difference in other factors; PWV increased with age; and that PWV was higher in those with additional diseases.

 Aim: This study aimed of our study is to investigate the factors affecting the level of arterial stiffness in cancer patients receiving immunotherapy. Materials and Methods: The height, weight, BMI, age, gender, type of cancer, previous cancer treatment, agents used in the treatment, current immunotherapy agents, comorbid conditions, smoking history of 42 patients diagnosed with renal cell carcinoma RCC, lung cancer, malignant melanoma and receiving immunotherapy treatment were recorded at the time of their first application and their arterial stiffness levels were measured. Following the first measurement, the patients were seen again in the third and sixth therapy cycles and their measurements were repeated and recorded. Factors affecting the arterial stiffness level of the patients were evaluated. Results: It was observed that pulse wave velocity NWV increased with increasing age p0.01. No significant difference was found between cancer type and PWV; however, patients with lung cancer had higher pulse pressure at the first measurement than other patients. No significant difference was found between immunotherapy agents and PWV. PWV was found to be significantly higher in those with concomitant diseases p0.005. Pulse pressure was found to be higher in smokers than in non-smokers p0.007. Conclusion: It was concluded that smoking, gender and cancer type were effective in the change of pulse pressure in cancer patients receiving immunotherapy, that there was no significant difference in other factors; PWV increased with age; and that PWV was higher in those with additional diseases.

 Aim: This study aimed of our study is to investigate the factors affecting the level of arterial stiffness in cancer patients receiving immunotherapy. Materials and Methods: The height, weight, BMI, age, gender, type of cancer, previous cancer treatment, agents used in the treatment, current immunotherapy agents, comorbid conditions, smoking history of 42 patients diagnosed with renal cell carcinoma RCC, lung cancer, malignant melanoma and receiving immunotherapy treatment were recorded at the time of their first application and their arterial stiffness levels were measured. Following the first measurement, the patients were seen again in the third and sixth therapy cycles and their measurements were repeated and recorded. Factors affecting the arterial stiffness level of the patients were evaluated. Results: It was observed that pulse wave velocity NWV increased with increasing age p0.01. No significant difference was found between cancer type and PWV; however, patients with lung cancer had higher pulse pressure at the first measurement than other patients. No significant difference was found between immunotherapy agents and PWV. PWV was found to be significantly higher in those with concomitant diseases p0.005. Pulse pressure was found to be higher in smokers than in non-smokers p0.007. Conclusion: It was concluded that smoking, gender and cancer type were effective in the change of pulse pressure in cancer patients receiving immunotherapy, that there was no significant difference in other factors; PWV increased with age; and that PWV was higher in those with additional diseases.

 Amaç: Bu çalışmanın amacı, immünoterapi alan kanser hastalarında arteriyel sertlik düzeyini etkileyen faktörleri araştırmaktır. Gereç ve Yöntemler: Renal hücreli karsinom RCC, akciğer kanseri, malign melanom tanısı almış ve immünoterapi tedavisi gören 42 hastanın boyu, kilosu, VKİsi, yaşı, cinsiyeti, kanser türü, daha önce kanser tedavisi görmesi, tedavide kullanılan ajanlar, mevcut immünoterapi ajanları, eşlik eden hastalıkları, sigara içme öyküsü ilk başvuru anında kaydedildi ve arteriyel sertlik düzeyleri ölçüldü. İlk ölçümün ardından hastalar üçüncü ve altıncı tedavi sikluslarında tekrar görüldü ve ölçümleri tekrarlanarak kaydedildi. Hastaların arteriyel sertlik düzeyini etkileyen faktörler değerlendirildi. Bulgular: Nabız dalga hızının NWV artan yaşla birlikte arttığı görüldü p0.01. Kanser türü ile PWV arasında anlamlı bir fark bulunmadı; ancak akciğer kanserli hastaların ilk ölçümde diğer hastalara göre daha yüksek nabız basıncı vardı. İmmünoterapi ajanları ile PWV arasında anlamlı bir fark bulunmadı. Eşlik eden hastalıkları olanlarda PWV anlamlı olarak daha yüksek bulundu p0.005. Nabız basıncı sigara içenlerde sigara içmeyenlere göre daha yüksek bulundu p0.007. Sonuç: İmmünoterapi alan kanser hastalarında nabız basıncının değişiminde sigara içmenin, cinsiyetin ve kanser tipinin etkili olduğu, diğer faktörlerde anlamlı bir fark olmadığı, PWVnin yaşla arttığı ve ek hastalıkları olanlarda PWVnin daha yüksek olduğu sonucuna varıldı.

Makale detayları

Factors Affecting Arterial Stiffness Level in Cancer Patients Receiving Immunotherapy

Yazarlar:

Esra Güner | Merve Bıyıklı Alemdar | Bilgin Demir | Merve Turan | Esin Oktay

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.101-107

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342929

pISSN:

2149-9063

Arterial stiffness

immunotherapy

cancerArteriyel sertlik

immünoterapi

kanser

Sayı

Makale detayları

Factors Affecting Arterial Stiffness Level in Cancer Patients Receiving Immunotherapy

Yazarlar: Esra Güner | Merve Bıyıklı Alemdar | Bilgin Demir | Merve Turan | Esin Oktay

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Clinical Oncology

Dergi: Meandros Medical And Dental Journal Vol.26 Issue 1, pp.101-107

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342929

pISSN: 2149-9063

Arterial stiffness

immunotherapy

cancerArteriyel sertlik

immünoterapi

kanser

Sayı

Yazarlar:

Esra Güner | Merve Bıyıklı Alemdar | Bilgin Demir | Merve Turan | Esin Oktay

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 1, pp.101-107

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342929

pISSN:

2149-9063