Cytokine gene variants/expressions and non-syndromic microtia – is there a link?

Ayşe Feyda NURSAL; Mehmet BEKERECİOĞLU; Sacide PEHLİVAN; Tuğçe SEVER; Berker BÜYÜKGÜRAL

Makale detayları

Cytokine gene variants/expressions and non-syndromic microtia – is there a link?

Yazarlar:

Ayşe Feyda NURSAL | Mehmet BEKERECİOĞLU | Sacide PEHLİVAN | Tuğçe SEVER | Berker BÜYÜKGÜRAL

Yayıncı:

Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Dergi:

ENT Updates 2017 Vol.7 Issue 2, pp.62-67

Belge Tipi:

Makale

Yayın Tarihi:

9/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000781850

Sıklık:

Üç Yıllık

eISSN:

2149-6498

pISSN:

2149-7109

Özet:

 


Objective: Although  many  genetic  and  environmental  factors  are investigated the etiopathogenesis of microtia, it still remains unclear. We  investigated  the  relationship  between  the  variants/expression  of pro-  and  anti-inflammatory  cytokines  [interleukin  (IL)  6,  IL-10, tumor  necrosis  factor-alpha  (TNF-α),  transforming  growth  factor beta  (TGF-β1),  interferon  gamma  (IFN-γ)]  and  susceptibility  non-syndromic microtia in a Turkish cohort. 

Methods: Nineteen  unrelated  cases  with  microtia  and  40  healthy controls  were  included  in  the  present  study.  Cytokine  variants  were tested  by  polymerase  chain  reaction  with  sequence-specific  primers (PCR-SSP) method. 

Results: It  was  found  that  IL-6  (-174)  GG  genotype  (high  expression)  was  higher  in  microtia  cases  than  the  controls  (p=0.010)  while IL-6  (-174)  GC  (high  expression)  genotype  was  lower  in  patients (p=0.003).  For  IL-6  (-174),  patients  with  GG  genotype  had  a  5895-fold  increased  risk  for  microtia.  IFN-γ (+874)  variant  AA  genotype (low expression) was lower in microtia cases (p=0.009). IL-6 (-174) Gallele was more prevalent in patient group compared to controls while C allele was lower in patients than controls (p=0.003). IFN-γ (+874) variant T allele was more prevalent in cases while A allele was lowerin cases (p=0.017). Conclusion: We  have  demonstrated  for  the  first  time  that  the cytokine variants constitute risk factors for developing microtia. Our study suggests that the IFN-γ (+874) and IL-6 (-174) variants may be considered as a risk factor for microtia in a Turkish cohorts. 



 


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Makale detayları

Cytokine gene variants/expressions and non-syndromic microtia – is there a link?

Yazarlar: Ayşe Feyda NURSAL | Mehmet BEKERECİOĞLU | Sacide PEHLİVAN | Tuğçe SEVER | Berker BÜYÜKGÜRAL

Yayıncı: Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Dergi: ENT Updates 2017 Vol.7 Issue 2, pp.62-67

Belge Tipi: Makale

Yayın Tarihi: 9/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000781850

Sıklık: Üç Yıllık

eISSN: 2149-6498

pISSN: 2149-7109

Sayı

Yazarlar:

Ayşe Feyda NURSAL | Mehmet BEKERECİOĞLU | Sacide PEHLİVAN | Tuğçe SEVER | Berker BÜYÜKGÜRAL

Yayıncı:

Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Dergi:

ENT Updates 2017 Vol.7 Issue 2, pp.62-67

Belge Tipi:

Makale

Yayın Tarihi:

9/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000781850

Sıklık:

Üç Yıllık

eISSN:

2149-6498

pISSN:

2149-7109