Role of endothelial nitric oxide synthase gene in vascular diseases

M.s. AKHTER; Arijit BİSWAS; Renu SAXENA

Makale detayları

Role of endothelial nitric oxide synthase gene in vascular diseases

Yazarlar:

M.s. AKHTER | Arijit BİSWAS | Renu SAXENA

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2009 Vol.14 Issue 2, pp.46-50

Belge Tipi:

Makale

Yayın Tarihi:

1/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000773222

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883

Özet:

 


Abstract. The endothelial nitric oxide synthase (eNOS or NOS 3) is expressed in the endothelium where it produces Nitric Oxide (NO) from L-arginine. NO a powerful short lived vascular substance, plays a key role to maintain vascular homeostasis. Association of endothelial nitric oxide synthase gene variants and nitric oxide has been found in many vascular diseases chiefly stroke, coronary artery disease and hypertension. The variants have been associated with low plasma nitric oxide concentrations and reduced vascular reactivity, however difficulties in measuring those phenotypes implicates that their functions remain unclear. While a large no of studies report the association of NOS3 gene with vascular diseases, a few are contradictory to such reports. So a need for large scale genetic association studies using tagging polymorphisms to confirm or refute the role of NOS3 gene in vascular diseases is strongly warranted.

Key words: Vascular diseaser, eadotelial nitric oxide

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Makale detayları

Role of endothelial nitric oxide synthase gene in vascular diseases

Yazarlar: M.s. AKHTER | Arijit BİSWAS | Renu SAXENA

Yayıncı: Van Yuzuncu Yıl University

Dergi: EASTERN JOURNAL OF MEDICINE 2009 Vol.14 Issue 2, pp.46-50

Belge Tipi: Makale

Yayın Tarihi: 1/2013

Belge Dili: İngilizce

Document ID (Org No.): 2000773222

Sıklık: Aylık

eISSN: 1301-0883

pISSN: 1301-0883

Sayı

Yazarlar:

M.s. AKHTER | Arijit BİSWAS | Renu SAXENA

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2009 Vol.14 Issue 2, pp.46-50

Belge Tipi:

Makale

Yayın Tarihi:

1/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000773222

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883