The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

Betül Sargın; Ayla Akbal; Hatice Resorlu; Yılmaz Savaş; Coşkun Zateri; Fatma Sılan; Öztürk Özdemir

doi:https://doi.org/10.18621/eurj.346968

Makale detayları

The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

Yazarlar:

Betül Sargın | Ayla Akbal | Hatice Resorlu | Yılmaz Savaş | Coşkun Zateri | Fatma Sılan | Öztürk Özdemir

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 2, pp.106-111

Belge Tipi:

Makale

Yayın Tarihi:

4/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663257

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.346968

Özet:

 


Objectives. We aimed to evaluate the frequency of toll-like
receptor 4 (TLR4) gene polymorphism and its relationship between disease
activity in patients with ankylosing spondylitis (AS). Methods. Forty-one AS patients (25 male/16
female) fullfilling the 1984 Modified New York Criteria and 41
healthy
controls (25 male/16
female) were included in this study. Disease activity of the AS patients was
assesed by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthy controls were analyzed by
Real-Time Polymerase Chain Reaction (PCR) System. Results.
Three (7.3%) patients with AS had TLR4 gene polymorphism compared with healthy
controls (0/41; 0%). Two of these patients had heterozygous mutation and one
had homozygous mutation. Significant correlation was not found between TLR4
gene polymorphism and BASDAI score (p
> 0.05). Conclusions. In our study, TLR4
gene polymorphism was higher in patients with AS compared with control group. But,
this polymorphism was not associated with disease activity, erythrocyte sedimentation rate and C-reactive protein
levels. 



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Makale detayları

The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

Yazarlar: Betül Sargın | Ayla Akbal | Hatice Resorlu | Yılmaz Savaş | Coşkun Zateri | Fatma Sılan | Öztürk Özdemir

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2018 Vol.4 Issue 2, pp.106-111

Belge Tipi: Makale

Yayın Tarihi: 4/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000663257

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.346968

Sayı

Yazarlar:

Betül Sargın | Ayla Akbal | Hatice Resorlu | Yılmaz Savaş | Coşkun Zateri | Fatma Sılan | Öztürk Özdemir

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 2, pp.106-111

Belge Tipi:

Makale

Yayın Tarihi:

4/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663257

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.346968