Comparative evaluation of Irvingia gabonensis seed fat extract and other bases in promethazine hydrochloride suppository formulations

Olubunmi Olayemi; Martins Emeje

Makale detayları

Comparative evaluation of Irvingia gabonensis seed fat extract and other bases in promethazine hydrochloride suppository formulations

Yazarlar:

Olubunmi Olayemi | Martins Emeje

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 2, pp.240-250

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346036

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 A study has been made on the formulation and evaluation of promethazine hydrochloride suppositories using dika fat DF from Irvingia gabonensis seeds as a base comparatively with both water and fatty soluble bases. Rectal suppositories containing promethazine hydrochloride 25 mg in pre-calibrated mould were prepared by fusion method using DF, macrogol MG, cocoa butter CB and cocoa butter  10ww weight by weight beeswax CBW as bases. Thereafter the suppositories were characterized using parameters such as appearance, crushing strength, weight variation, melting point, pH, liquefaction time, content uniformity, and in vitro release in accordance with standard procedures. Results obtained indicated that the bases used generally could be ranked in the order of DF  CB  MG  CBW in terms of favourable physicochemical properties investigated. The foregoing indicates that DF has promising potential and could be a substitute suppository base in the formulation of promethazine hydrochloride suppositories.

 A study has been made on the formulation and evaluation of promethazine hydrochloride suppositories using dika fat DF from Irvingia gabonensis seeds as a base comparatively with both water and fatty soluble bases. Rectal suppositories containing promethazine hydrochloride 25 mg in pre-calibrated mould were prepared by fusion method using DF, macrogol MG, cocoa butter CB and cocoa butter  10ww weight by weight beeswax CBW as bases. Thereafter the suppositories were characterized using parameters such as appearance, crushing strength, weight variation, melting point, pH, liquefaction time, content uniformity, and in vitro release in accordance with standard procedures. Results obtained indicated that the bases used generally could be ranked in the order of DF  CB  MG  CBW in terms of favourable physicochemical properties investigated. The foregoing indicates that DF has promising potential and could be a substitute suppository base in the formulation of promethazine hydrochloride suppositories.

 A study has been made on the formulation and evaluation of promethazine hydrochloride suppositories using dika fat DF from Irvingia gabonensis seeds as a base comparatively with both water and fatty soluble bases. Rectal suppositories containing promethazine hydrochloride 25 mg in pre-calibrated mould were prepared by fusion method using DF, macrogol MG, cocoa butter CB and cocoa butter  10ww weight by weight beeswax CBW as bases. Thereafter the suppositories were characterized using parameters such as appearance, crushing strength, weight variation, melting point, pH, liquefaction time, content uniformity, and in vitro release in accordance with standard procedures. Results obtained indicated that the bases used generally could be ranked in the order of DF  CB  MG  CBW in terms of favourable physicochemical properties investigated. The foregoing indicates that DF has promising potential and could be a substitute suppository base in the formulation of promethazine hydrochloride suppositories.

 A study has been made on the formulation and evaluation of promethazine hydrochloride suppositories using dika fat DF from Irvingia gabonensis seeds as a base comparatively with both water and fatty soluble bases. Rectal suppositories containing promethazine hydrochloride 25 mg in pre-calibrated mould were prepared by fusion method using DF, macrogol MG, cocoa butter CB and cocoa butter  10ww weight by weight beeswax CBW as bases. Thereafter the suppositories were characterized using parameters such as appearance, crushing strength, weight variation, melting point, pH, liquefaction time, content uniformity, and in vitro release in accordance with standard procedures. Results obtained indicated that the bases used generally could be ranked in the order of DF  CB  MG  CBW in terms of favourable physicochemical properties investigated. The foregoing indicates that DF has promising potential and could be a substitute suppository base in the formulation of promethazine hydrochloride suppositories.

Makale detayları

Comparative evaluation of Irvingia gabonensis seed fat extract and other bases in promethazine hydrochloride suppository formulations

Yazarlar:

Olubunmi Olayemi | Martins Emeje

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 2, pp.240-250

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346036

pISSN:

2630-6344

Formulation

suppositories

promethazine hydrochloride

Dika fat

Sayı

Makale detayları

Comparative evaluation of Irvingia gabonensis seed fat extract and other bases in promethazine hydrochloride suppository formulations

Yazarlar: Olubunmi Olayemi | Martins Emeje

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 2, pp.240-250

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346036

pISSN: 2630-6344

Formulation

suppositories

promethazine hydrochloride

Dika fat

Sayı

Yazarlar:

Olubunmi Olayemi | Martins Emeje

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 2, pp.240-250

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346036

pISSN:

2630-6344