Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Zerrin Sezgin Bayındır

Makale detayları

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Yazarlar:

Zerrin Sezgin Bayındır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.914-926

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347979

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 S-adenosyl-L-methionine SAMe is an endogenic methyl donor naturally present in all living cells; it has high water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aim of this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparation of the formulations, the effects of chitosan concentration, tripolyphosphate TPP concentration and the amount of SAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, and process yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry DSC and Fourier transform infrared FTIR spectroscopy. The obtained nanoparticles showed bimodal particle size distribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drug encapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the process parameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount were significant parameters affecting particle size. The chitosan concentration was also found to have a significant effect on process yield p 0.05. Drug release from nanoparticles was evaluated according to different kinetic models and it was found that the release mechanism was Fickian diffusion.

 S-adenosyl-L-methionine SAMe is an endogenic methyl donor naturally present in all living cells; it has high water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aim of this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparation of the formulations, the effects of chitosan concentration, tripolyphosphate TPP concentration and the amount of SAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, and process yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry DSC and Fourier transform infrared FTIR spectroscopy. The obtained nanoparticles showed bimodal particle size distribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drug encapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the process parameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount were significant parameters affecting particle size. The chitosan concentration was also found to have a significant effect on process yield p 0.05. Drug release from nanoparticles was evaluated according to different kinetic models and it was found that the release mechanism was Fickian diffusion.

 S-adenosyl-L-methionine SAMe is an endogenic methyl donor naturally present in all living cells; it has high water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aim of this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparation of the formulations, the effects of chitosan concentration, tripolyphosphate TPP concentration and the amount of SAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, and process yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry DSC and Fourier transform infrared FTIR spectroscopy. The obtained nanoparticles showed bimodal particle size distribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drug encapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the process parameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount were significant parameters affecting particle size. The chitosan concentration was also found to have a significant effect on process yield p 0.05. Drug release from nanoparticles was evaluated according to different kinetic models and it was found that the release mechanism was Fickian diffusion.

 S-adenosyl-L-methionine SAMe is an endogenic methyl donor naturally present in all living cells; it has high water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aim of this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparation of the formulations, the effects of chitosan concentration, tripolyphosphate TPP concentration and the amount of SAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, and process yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry DSC and Fourier transform infrared FTIR spectroscopy. The obtained nanoparticles showed bimodal particle size distribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drug encapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the process parameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount were significant parameters affecting particle size. The chitosan concentration was also found to have a significant effect on process yield p 0.05. Drug release from nanoparticles was evaluated according to different kinetic models and it was found that the release mechanism was Fickian diffusion.

Makale detayları

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Yazarlar:

Zerrin Sezgin Bayındır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.914-926

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347979

pISSN:

2630-6344

S-adenosylmethionine

chitosan

nanoparticle

colon

bioavailibility

Sayı

Makale detayları

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Yazarlar: Zerrin Sezgin Bayındır

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.23 Issue 5, pp.914-926

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347979

pISSN: 2630-6344

S-adenosylmethionine

chitosan

nanoparticle

colon

bioavailibility

Sayı

Yazarlar:

Zerrin Sezgin Bayındır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biotechnology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.914-926

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347979

pISSN:

2630-6344