Evaluation of in vitro antioxidants activities, hepatoprotective and haematological effects of ethanol extract of Anthocleista vogelii stem bark (AVSB) on carbon tetrachloride (CCl4) induced rats

N.A.

Makale detayları

Evaluation of in vitro antioxidants activities, hepatoprotective and haematological effects of ethanol extract of Anthocleista vogelii stem bark (AVSB) on carbon tetrachloride (CCl4) induced rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry | Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.258-270

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347922

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Anthocleista vogelii stem bark extract AVSB is used as a hepatoprotective protective and blood-boosting agent locally without any scientific evidence. This study evaluated the in vitro antioxidants activity, hepatoprotective and haematological effects of ethanol extract of AVSB on carbon tetrachloride CCl4 induced rats. Thirty rats distributed into 5 groups n  6 were used. Group 1 was the normal control rats without CCl4 induction, group 2 was the CCl4 control CCl4 induced untreated rats while groups 3  6 were CCl4 induced rats treated with 100 mgkgday of silymarin, 100, 200 and 500 mgkgday of AVSB respectively for 14 days. The results indicated high levels of total phenols, flavonoid, vitamin E, vitamin C, -carotene and lycopene in the AVSB. The AVSB exhibited a dose-dependent increase in ferric reducing antioxidant power, DPPH and nitric oxide radicals scavenging activities similar to vitamin C, rutin and curcumin respectively. The CCl4 induction significantly P0.05 elevated total bilirubin concentrations, serum ALT, AST and ALP activities and significantly P0.05 decreased PCV, RBC, WBC, platelet counts, and Hb, total protein and albumin concentrations and caused liver necrosis in the untreated rats relative to the normal control. Treatment with AVSB significantly reversed the altered serum ALT, AST and ALP activities, total bilirubin, total protein, albumin and Hb concentrations including haematological indices and liver histomorphology to normal compared with the CCl4 control. The findings of this study indicated that the AVSB is rich in antioxidant components, in vitro antioxidant activity, and possesses hepatoprotective and improves haematological indices.

 Anthocleista vogelii stem bark extract AVSB is used as a hepatoprotective protective and blood-boosting agent locally without any scientific evidence. This study evaluated the in vitro antioxidants activity, hepatoprotective and haematological effects of ethanol extract of AVSB on carbon tetrachloride CCl4 induced rats. Thirty rats distributed into 5 groups n  6 were used. Group 1 was the normal control rats without CCl4 induction, group 2 was the CCl4 control CCl4 induced untreated rats while groups 3  6 were CCl4 induced rats treated with 100 mgkgday of silymarin, 100, 200 and 500 mgkgday of AVSB respectively for 14 days. The results indicated high levels of total phenols, flavonoid, vitamin E, vitamin C, -carotene and lycopene in the AVSB. The AVSB exhibited a dose-dependent increase in ferric reducing antioxidant power, DPPH and nitric oxide radicals scavenging activities similar to vitamin C, rutin and curcumin respectively. The CCl4 induction significantly P0.05 elevated total bilirubin concentrations, serum ALT, AST and ALP activities and significantly P0.05 decreased PCV, RBC, WBC, platelet counts, and Hb, total protein and albumin concentrations and caused liver necrosis in the untreated rats relative to the normal control. Treatment with AVSB significantly reversed the altered serum ALT, AST and ALP activities, total bilirubin, total protein, albumin and Hb concentrations including haematological indices and liver histomorphology to normal compared with the CCl4 control. The findings of this study indicated that the AVSB is rich in antioxidant components, in vitro antioxidant activity, and possesses hepatoprotective and improves haematological indices.

 Anthocleista vogelii stem bark extract AVSB is used as a hepatoprotective protective and blood-boosting agent locally without any scientific evidence. This study evaluated the in vitro antioxidants activity, hepatoprotective and haematological effects of ethanol extract of AVSB on carbon tetrachloride CCl4 induced rats. Thirty rats distributed into 5 groups n  6 were used. Group 1 was the normal control rats without CCl4 induction, group 2 was the CCl4 control CCl4 induced untreated rats while groups 3  6 were CCl4 induced rats treated with 100 mgkgday of silymarin, 100, 200 and 500 mgkgday of AVSB respectively for 14 days. The results indicated high levels of total phenols, flavonoid, vitamin E, vitamin C, -carotene and lycopene in the AVSB. The AVSB exhibited a dose-dependent increase in ferric reducing antioxidant power, DPPH and nitric oxide radicals scavenging activities similar to vitamin C, rutin and curcumin respectively. The CCl4 induction significantly P0.05 elevated total bilirubin concentrations, serum ALT, AST and ALP activities and significantly P0.05 decreased PCV, RBC, WBC, platelet counts, and Hb, total protein and albumin concentrations and caused liver necrosis in the untreated rats relative to the normal control. Treatment with AVSB significantly reversed the altered serum ALT, AST and ALP activities, total bilirubin, total protein, albumin and Hb concentrations including haematological indices and liver histomorphology to normal compared with the CCl4 control. The findings of this study indicated that the AVSB is rich in antioxidant components, in vitro antioxidant activity, and possesses hepatoprotective and improves haematological indices.

 Anthocleista vogelii stem bark extract AVSB is used as a hepatoprotective protective and blood-boosting agent locally without any scientific evidence. This study evaluated the in vitro antioxidants activity, hepatoprotective and haematological effects of ethanol extract of AVSB on carbon tetrachloride CCl4 induced rats. Thirty rats distributed into 5 groups n  6 were used. Group 1 was the normal control rats without CCl4 induction, group 2 was the CCl4 control CCl4 induced untreated rats while groups 3  6 were CCl4 induced rats treated with 100 mgkgday of silymarin, 100, 200 and 500 mgkgday of AVSB respectively for 14 days. The results indicated high levels of total phenols, flavonoid, vitamin E, vitamin C, -carotene and lycopene in the AVSB. The AVSB exhibited a dose-dependent increase in ferric reducing antioxidant power, DPPH and nitric oxide radicals scavenging activities similar to vitamin C, rutin and curcumin respectively. The CCl4 induction significantly P0.05 elevated total bilirubin concentrations, serum ALT, AST and ALP activities and significantly P0.05 decreased PCV, RBC, WBC, platelet counts, and Hb, total protein and albumin concentrations and caused liver necrosis in the untreated rats relative to the normal control. Treatment with AVSB significantly reversed the altered serum ALT, AST and ALP activities, total bilirubin, total protein, albumin and Hb concentrations including haematological indices and liver histomorphology to normal compared with the CCl4 control. The findings of this study indicated that the AVSB is rich in antioxidant components, in vitro antioxidant activity, and possesses hepatoprotective and improves haematological indices.

Makale detayları

Evaluation of in vitro antioxidants activities, hepatoprotective and haematological effects of ethanol extract of Anthocleista vogelii stem bark (AVSB) on carbon tetrachloride (CCl4) induced rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biochemistry | Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.25 Issue 3, pp.258-270

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347922

pISSN: 2630-6344

Anthocleista vogelii

antioxidant activity

carbon tetrachloride

hepatoprotective

haematological indices.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry | Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.258-270

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347922

pISSN:

2630-6344