Prediction of long-term ischemic stroke with estimated whole blood viscosity in heart failure patients

Duygu İnan; Aslan Erdoğan

Makale detayları

Prediction of long-term ischemic stroke with estimated whole blood viscosity in heart failure patients

Yazarlar:

Duygu İnan | Aslan Erdoğan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.16-22

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312449

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: Heart failure HF and stroke often coexist and share common risk factors, including atrial fibrillation. Whole blood viscosity WBV, one of the most significant indicators of endothelial stress, is a fundamental determinant of blood flow and is involved in the aetiology of atherosclerosis and thrombosis. The purpose of this study was to assess the association between estimated WBV and long-term ischemic stroke IS risk in patients hospitalized for acute HF. Methods: A total of 409 patients with reduced ejection fraction HF hospitalized with acute HF were included. The primary outcome was IS post-discharge follow-up. Results: IS occurred in 26 6 patients during a follow-up. In the IS group, older age, diabetes mellitus frequency and WBV were higher, left ventricular end-diastolic and left atrial anteroposterior diameter were increased and left ventricular ejection fraction was lower. In multivariate regression analysis, WBV was found to be a predictor of long-term IS OR, 2.68; 95 CI, 1.96-3.12, p0.008. In the receiver operating characteristic curve, the optimal cut-off value of WBV for one-year IS was 6.28 with 61.5 sensitivity and 70.2 specificity area under the curve: 0.748. Conclusion: WBV is a novel, easily measurable, cost-effective, non-invasive risk marker for the prediction of long-term IS in patients with HF, independent of traditional risk factors.

 Aims: Heart failure HF and stroke often coexist and share common risk factors, including atrial fibrillation. Whole blood viscosity WBV, one of the most significant indicators of endothelial stress, is a fundamental determinant of blood flow and is involved in the aetiology of atherosclerosis and thrombosis. The purpose of this study was to assess the association between estimated WBV and long-term ischemic stroke IS risk in patients hospitalized for acute HF. Methods: A total of 409 patients with reduced ejection fraction HF hospitalized with acute HF were included. The primary outcome was IS post-discharge follow-up. Results: IS occurred in 26 6 patients during a follow-up. In the IS group, older age, diabetes mellitus frequency and WBV were higher, left ventricular end-diastolic and left atrial anteroposterior diameter were increased and left ventricular ejection fraction was lower. In multivariate regression analysis, WBV was found to be a predictor of long-term IS OR, 2.68; 95 CI, 1.96-3.12, p0.008. In the receiver operating characteristic curve, the optimal cut-off value of WBV for one-year IS was 6.28 with 61.5 sensitivity and 70.2 specificity area under the curve: 0.748. Conclusion: WBV is a novel, easily measurable, cost-effective, non-invasive risk marker for the prediction of long-term IS in patients with HF, independent of traditional risk factors.

 Aims: Heart failure HF and stroke often coexist and share common risk factors, including atrial fibrillation. Whole blood viscosity WBV, one of the most significant indicators of endothelial stress, is a fundamental determinant of blood flow and is involved in the aetiology of atherosclerosis and thrombosis. The purpose of this study was to assess the association between estimated WBV and long-term ischemic stroke IS risk in patients hospitalized for acute HF. Methods: A total of 409 patients with reduced ejection fraction HF hospitalized with acute HF were included. The primary outcome was IS post-discharge follow-up. Results: IS occurred in 26 6 patients during a follow-up. In the IS group, older age, diabetes mellitus frequency and WBV were higher, left ventricular end-diastolic and left atrial anteroposterior diameter were increased and left ventricular ejection fraction was lower. In multivariate regression analysis, WBV was found to be a predictor of long-term IS OR, 2.68; 95 CI, 1.96-3.12, p0.008. In the receiver operating characteristic curve, the optimal cut-off value of WBV for one-year IS was 6.28 with 61.5 sensitivity and 70.2 specificity area under the curve: 0.748. Conclusion: WBV is a novel, easily measurable, cost-effective, non-invasive risk marker for the prediction of long-term IS in patients with HF, independent of traditional risk factors.

 Amaç: Kalp yetmezliği KY ve inme sıklıkla bir arada bulunur ve atriyal fibrilasyon gibi ortak risk faktörlerini paylaşır. Endotel stresinin en önemli göstergelerinden biri olan tam kan viskozitesi WBV, kan akışının temel bir belirleyicisidir, ateroskleroz ve tromboz etiyolojisinde rol oynar. Bu çalışmanın amacı, akut KY nedeniyle hastaneye yatırılan hastalarda tahmini WBV ile uzun vadeli iskemik strok IS riski arasındaki ilişkiyi değerlendirmektir. Yöntemler: Akut KY nedeniyle hastaneye yatırılan ejeksiyon fraksiyonu düşük toplam 409 hasta çalışmaya dahil edildi. Birincil sonuç taburculuk sonrası takipte İS gelişimidir. Sonuçlar: Takip süresince 26 6 hastada İS meydana geldi. İS grubunda ileri yaş, diabetes mellitus daha sık ve WBV daha yüksek, sol ventrikül diyastol sonu ve sol atriyum ön-arka çapı artmış ve sol ventrikül ejeksiyon fraksiyonu daha düşüktü. Çok değişkenli regresyon analizinde, WBV uzun dönem İSnin bir ön gördürücüsü olarak tespit edilmiştirOR, 2.68; 95 GA, 1.96 - 3.12, p0.008. Alıcı işletim karakteristik eğrisinde, bir yıllık İS için WBVnin optimal kesme değeri 61,5 duyarlılık ve 70,2 özgüllük ile 6,28 idi eğri altındaki alan: 0,748. Sonuç: WBV, geleneksel risk faktörlerinden bağımsız olarak KY hastalarında uzun vadeli İSnin öngörülmesi için yeni, kolay ölçülebilir, maliyet etkin, invazif olmayan bir risk belirtecidir.

Makale detayları

Prediction of long-term ischemic stroke with estimated whole blood viscosity in heart failure patients

Yazarlar:

Duygu İnan | Aslan Erdoğan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.16-22

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312449

pISSN:

2717-7505

Heart failure

ischemic stroke

whole blood viscosityiskemik inme

tam kan viskozitesi

kalp yetersizliği

Sayı

Makale detayları

Prediction of long-term ischemic stroke with estimated whole blood viscosity in heart failure patients

Yazarlar: Duygu İnan | Aslan Erdoğan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kardiyoloji

Dergi: Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.16-22

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312449

pISSN: 2717-7505

Heart failure

ischemic stroke

whole blood viscosityiskemik inme

tam kan viskozitesi

kalp yetersizliği

Sayı

Yazarlar:

Duygu İnan | Aslan Erdoğan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.16-22

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312449

pISSN:

2717-7505