GREEN METHOD FOR QUANTITATIVE DETERMINATION: ATR-FTIR; DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL PREPARATION

Nükte Topraksever; Gamze Özgül Artuç

Makale detayları

GREEN METHOD FOR QUANTITATIVE DETERMINATION: ATR-FTIR; DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL PREPARATION

Yazarlar:

Nükte Topraksever | Gamze Özgül Artuç

Yayıncı:

Istanbul Ticaret University

Ana Başlıklar:

Analitik Spektrometri | Enstrümantal Yöntemler | Organik Yeşil Kimya

Dergi:

İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi Vol.22 Issue 44, pp.425-433

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305098

pISSN:

1305-7820

Anahtar kelimeler:

Özet:

 In this study, attenuated total reflectance Fourier transform infrared ATR-FTIR spectroscopy was used for the determination of paracetamol in pharmaceutical preparation. Paracetamol standard concentrations were prepared between 20 and 100 ww by dilution with NaCl. The FTIR spectrum of the paracetamol standard was taken and the calibration curve was plotted using the varying percentage transmittance of the characteristic CO peak. This curve showed good linearity with a regression coefficient R2 of 0,9993. Quantification was carried out in commercial pharmaceutical preparation containing paracetamol. The recovery of the quantification of paracetamol in pharmaceutical preparation is  100. The ATR-FTIR method applied to pharmaceutical preparation is suitable for the routine determination of paracetamol.

 In this study, attenuated total reflectance Fourier transform infrared ATR-FTIR spectroscopy was used for the determination of paracetamol in pharmaceutical preparation. Paracetamol standard concentrations were prepared between 20 and 100 ww by dilution with NaCl. The FTIR spectrum of the paracetamol standard was taken and the calibration curve was plotted using the varying percentage transmittance of the characteristic CO peak. This curve showed good linearity with a regression coefficient R2 of 0,9993. Quantification was carried out in commercial pharmaceutical preparation containing paracetamol. The recovery of the quantification of paracetamol in pharmaceutical preparation is  100. The ATR-FTIR method applied to pharmaceutical preparation is suitable for the routine determination of paracetamol.

 In this study, attenuated total reflectance Fourier transform infrared ATR-FTIR spectroscopy was used for the determination of paracetamol in pharmaceutical preparation. Paracetamol standard concentrations were prepared between 20 and 100 ww by dilution with NaCl. The FTIR spectrum of the paracetamol standard was taken and the calibration curve was plotted using the varying percentage transmittance of the characteristic CO peak. This curve showed good linearity with a regression coefficient R2 of 0,9993. Quantification was carried out in commercial pharmaceutical preparation containing paracetamol. The recovery of the quantification of paracetamol in pharmaceutical preparation is  100. The ATR-FTIR method applied to pharmaceutical preparation is suitable for the routine determination of paracetamol.

 Bu çalışmada azaltılmış toplam yansıma Fourier dönüşümlü kızıl ötesi ATR-FTIR spektroskopisi kullanılarak farmasötik preparatta parasetamol tayin edilmiştir. Parasetamol standart konsantrasyonları NaCl ile seyreltilerek  20 ile  100 aa arasında hazırlanmıştır. Parasetamol standardının FTIR spektrumu alınarak karakteristik CO pikinin değişen yüzde geçirgenliği kullanılarak kalibrasyon eğrisi çizilmiştir. Regresyon katsayısı R2 0.9993 ile iyi bir doğrusallık göstermiştir. Parasetamol içeren ticari farmasötik preparattaki miktar tayini yapılmıştır. Farmasötik preparattaki parasetamol miktar tayininin geri kazanımı   100dür. Farmasötik preparata uygulanan ATR-FTIR yöntemi parasetamolün rutin tayini için uygundur.

Makale detayları

GREEN METHOD FOR QUANTITATIVE DETERMINATION: ATR-FTIR; DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL PREPARATION

Yazarlar:

Nükte Topraksever | Gamze Özgül Artuç

Yayıncı:

Istanbul Ticaret University

Ana Başlıklar:

Analitik Spektrometri | Enstrümantal Yöntemler | Organik Yeşil Kimya

Dergi:

İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi Vol.22 Issue 44, pp.425-433

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305098

pISSN:

1305-7820

ATR-FTIR

Pharmaceutical preparation

Paracetamol

Green ChemistryATR-FTIR

Farmasötik preparat

Parasetamol

Yeşil Kimya

Sayı

Makale detayları

Yazarlar: Nükte Topraksever | Gamze Özgül Artuç

Yayıncı: Istanbul Ticaret University

Ana Başlıklar: Analitik Spektrometri | Enstrümantal Yöntemler | Organik Yeşil Kimya

Dergi: İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi Vol.22 Issue 44, pp.425-433

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001305098

pISSN: 1305-7820

Sayı

Yazarlar:

Nükte Topraksever | Gamze Özgül Artuç

Yayıncı:

Istanbul Ticaret University

Ana Başlıklar:

Analitik Spektrometri | Enstrümantal Yöntemler | Organik Yeşil Kimya

Dergi:

İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi Vol.22 Issue 44, pp.425-433

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305098

pISSN:

1305-7820