Therapeutic effects of transcranial direct current stimulation on loss of motor function caused by experimental mild traumatic brain injury

Güven Akçay; Recep Baydemir

Makale detayları

Therapeutic effects of transcranial direct current stimulation on loss of motor function caused by experimental mild traumatic brain injury

Yazarlar:

Güven Akçay | Recep Baydemir

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.972-978

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286406

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Traumatic brain injury TBI is a serious illness that causes behavioral disorders such as locomotor activity, learning, and memory. This study aims to investigate the behavioral effects of transcranial Direct Current Stimulation tDCS treatment on locomotor activity in an experimental traumatic brain injury model and to investigate the levels of IL-1β and IL-18 in the motor cortex tissue. Materials and Methods: 30 male 3-month-old Wistar albino rats were used. The TBI model was established using the Marmarou method. 2 hours after TBI, sham and TBItDCS groups were treated with 0.5 mA 30 minutes anodal tDCS treatment for 2 days. Locomotor activity was evaluated in open field test. IL-1β and IL-18 levels in motor cortex tissue were measured by the ELISA method.. Results: Compared to the sham group, locomotor activity results showed significant decreases in the TBI group while the TBItDCS group showed significant increases compared to the TBI group. There were significant increases in IL-1β and IL-18 values in the motor cortex of the animals in the TBI group compared to the sham group, while there was a significant decrease in the TBItDCS group compared to the TBI group. Conclusion: tDCS treatment was shown to have therapeutic effects on neuroinflammation against traumatic brain injury.

 Purpose: Traumatic brain injury TBI is a serious illness that causes behavioral disorders such as locomotor activity, learning, and memory. This study aims to investigate the behavioral effects of transcranial Direct Current Stimulation tDCS treatment on locomotor activity in an experimental traumatic brain injury model and to investigate the levels of IL-1β and IL-18 in the motor cortex tissue. Materials and Methods: 30 male 3-month-old Wistar albino rats were used. The TBI model was established using the Marmarou method. 2 hours after TBI, sham and TBItDCS groups were treated with 0.5 mA 30 minutes anodal tDCS treatment for 2 days. Locomotor activity was evaluated in open field test. IL-1β and IL-18 levels in motor cortex tissue were measured by the ELISA method.. Results: Compared to the sham group, locomotor activity results showed significant decreases in the TBI group while the TBItDCS group showed significant increases compared to the TBI group. There were significant increases in IL-1β and IL-18 values in the motor cortex of the animals in the TBI group compared to the sham group, while there was a significant decrease in the TBItDCS group compared to the TBI group. Conclusion: tDCS treatment was shown to have therapeutic effects on neuroinflammation against traumatic brain injury.

 Purpose: Traumatic brain injury TBI is a serious illness that causes behavioral disorders such as locomotor activity, learning, and memory. This study aims to investigate the behavioral effects of transcranial Direct Current Stimulation tDCS treatment on locomotor activity in an experimental traumatic brain injury model and to investigate the levels of IL-1β and IL-18 in the motor cortex tissue. Materials and Methods: 30 male 3-month-old Wistar albino rats were used. The TBI model was established using the Marmarou method. 2 hours after TBI, sham and TBItDCS groups were treated with 0.5 mA 30 minutes anodal tDCS treatment for 2 days. Locomotor activity was evaluated in open field test. IL-1β and IL-18 levels in motor cortex tissue were measured by the ELISA method.. Results: Compared to the sham group, locomotor activity results showed significant decreases in the TBI group while the TBItDCS group showed significant increases compared to the TBI group. There were significant increases in IL-1β and IL-18 values in the motor cortex of the animals in the TBI group compared to the sham group, while there was a significant decrease in the TBItDCS group compared to the TBI group. Conclusion: tDCS treatment was shown to have therapeutic effects on neuroinflammation against traumatic brain injury.

 Amaç: Travmatik beyin hasarı TBH lokomotor aktivite, öğrenme ve hafıza gibi davranışsal bozukluklara neden olan ciddi bir hastalıktır. Bu çalışmanın amacı, deneysel travmatik beyin hasarı modelinde transkraniyal Doğru Akım Stimülasyonu tDAS tedavisinin lokomotor aktivite üzerindeki davranışsal etkilerini araştırmak ve motor korteks dokusunda IL-1β ve IL-18 düzeylerini incelemektir. Gereç ve Yöntem: 30 adet 3 aylık erkek Wistar albino sıçanlar kullanıldı. TBH modeli Marmarou yöntemi kullanılarak oluşturuldu. Sham ve TBHtDAS gruplarına TBHnın 2. saatinde başlanıp 2 gün boyunca günde 0.5 mA 30 dakika anodal tDAS tedavisi uygulandı. Lokomotor aktivite açık alan testinde değerlendirildi. Motor korteks dokusunda IL-1β ve IL-18 düzeyleri ELİSA yöntemi ile ölçüldü. Bulgular: Lokomotor aktivite sonuçları sham grubuna kıyasla TBH grubunda anlamlı düzeyde azalma görülürken, TBHtDAS grubunda TBH grubuna kıyasla anlamlı artma görüldü. TBH grubunun motor korteks IL-1β ve IL-18 değerlerinde sham grubuna kıyasla anlamlı artma tespit edilirken, TBHtDAS grubunda TBH grubuna kıyasla anlamlı bir azalam tespit edildi. Sonuç: Çalışmamızda, tDAS tedavisinin travmatik beyin hasarına karşı nöroinflamasyon üzerinde terapötik etkiye sahip olduğu gösterildi.

Makale detayları

Therapeutic effects of transcranial direct current stimulation on loss of motor function caused by experimental mild traumatic brain injury

Yazarlar:

Güven Akçay | Recep Baydemir

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.972-978

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286406

pISSN:

2602-3032

Motor Function

Therapeutic Treatment

Traumatic Brain Injury

transcranial Direct Current Stimulation

Motor fonksiyon

terapötik tedavi

travmatik beyin hasarı

transkraniyal doğru akım stimülasyonu

Sayı

Makale detayları

Yazarlar: Güven Akçay | Recep Baydemir

Yayıncı: Cukurova University

Ana Başlıklar: Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Cukurova Medical Journal Vol.48 Issue 3, pp.972-978

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286406

pISSN: 2602-3032

Sayı

Yazarlar:

Güven Akçay | Recep Baydemir

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.972-978

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286406

pISSN:

2602-3032