Lipid Profile & Apolipoproteins in Neonates in relation to Birth Weight and Gestational Maturity

Rakhi JAIN; VN TRIPATHI; Rupa SINGH; Kiran PANDEY

Makale detayları

Lipid Profile & Apolipoproteins in Neonates in relation to Birth Weight and Gestational Maturity

Yazarlar:

Rakhi JAIN | VN TRIPATHI | Rupa SINGH | Kiran PANDEY

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-7

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000743578

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 

Abstract 
Background: Cardiovascular disease is a common cause of death in developed countries and also is a rising trend in developing countries.The objective of this study was  to study lipid profile& apolipoproteins in neonates in relation to birth weight and gestational maturity. Methods:  A total of 150 neonates were selected which were grouped on the basis of gestational age and birth weight.Umbilical venous blood was collected from them. Lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, VLDL cholesterol, triglycerides), apolipoproteins (apo B and apo A-I) and atherogenic index   were evaluated and compared. Results: Total cholesterol (TC) and LDL were significantly higher in preterm low birth weight ( LBW ) newborns as compared to term LBW  neonates (P=0.05). VLDL and apolipoprotein B were increased highly significantly   in preterm LBW newborns   than in term LBW group( P=0.001) . TC/HDL and LDL/HDL were  significantly increased in preterm LBW newborns than in term LBW group(P=0.05) and  preterm NBW babies than term NBW group(P=0.05).Apo B/Apo A-I was highly significantly increased in preterm  neonates in comparison to term group(0.71v/s 0.54, P=0.001).  Gestational age  and birth weight were inversely correlated with TC, LDL ,   VLDL, apolipoprotein B , TC/HDL, LDL/HDL and  Apo B/Apo A-I. Conclusions: These findings demonstrate a trend towards worse lipid profile in preterm low birth weight newborns . There is a need to investigate if this atherogenic lipid profile is a marker for future cardiovascular diseases.

Makale detayları

Lipid Profile & Apolipoproteins in Neonates in relation to Birth Weight and Gestational Maturity

Yazarlar: Rakhi JAIN | VN TRIPATHI | Rupa SINGH | Kiran PANDEY

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-7

Belge Tipi: Makale

Yayın Tarihi: 4/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000743578

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

Rakhi JAIN | VN TRIPATHI | Rupa SINGH | Kiran PANDEY

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-7

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000743578

Sıklık:

İki Yıllık

eISSN:

1309-1247