The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients

Leyla Ferlicolak

Makale detayları

The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients

Yazarlar:

Leyla Ferlicolak

Yayıncı:

Ankara University

Ana Başlıklar:

Internal Diseases

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.525-529

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349876

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Aim of this study was to evaluate hepcidin levels and its correlation with inflammatory markers, vitamin D levels as well as its effects on intensive care unit ICU mortality in critically ill coronavirus disease-2019 COVID-19 patients. Materials and Methods: Adult patients those were admitted to pandemic ICU between March 1st, 2021 and May 17th 2021 were prospectively included to the study. Hepcidin levels and inflammatory markers on day 1, 2, 3 and 7, admission vitamin D levels, length of ICU stay and ICU mortality were recorded and analysed. Results: Median age of patients was 60.5 52.50-71.25 and 20 66.7 of them was male. It was observed that hepcidin levels and lymphocyte counts were increased significantly from day 1 to day 7 p0.01 and p0.01, respectively. In contrast, C-reactive protein CRP and procalsitonin levels were decreased from day 1 to day 7 p0.01 and p0.01, respectively. In the analysis admission hepcidin levels and inflammatory markers IL-6 p0.61, CRP p0.82 and ferritin p0.27, vitamin D p0.13 and iron level p0.90 was not correlated. There was no correlation between hepcidin levels and ICU mortality p0.95 Conclusion: In this study, hepcidin levels were above normal limits in critically ill COVID-19 patients. However, our findings do not support the use of hepcidin, IL6, serum ferritin, and vitamin D levels in predicting COVID-19 mortality.

 Objectives: Aim of this study was to evaluate hepcidin levels and its correlation with inflammatory markers, vitamin D levels as well as its effects on intensive care unit ICU mortality in critically ill coronavirus disease-2019 COVID-19 patients. Materials and Methods: Adult patients those were admitted to pandemic ICU between March 1st, 2021 and May 17th 2021 were prospectively included to the study. Hepcidin levels and inflammatory markers on day 1, 2, 3 and 7, admission vitamin D levels, length of ICU stay and ICU mortality were recorded and analysed. Results: Median age of patients was 60.5 52.50-71.25 and 20 66.7 of them was male. It was observed that hepcidin levels and lymphocyte counts were increased significantly from day 1 to day 7 p0.01 and p0.01, respectively. In contrast, C-reactive protein CRP and procalsitonin levels were decreased from day 1 to day 7 p0.01 and p0.01, respectively. In the analysis admission hepcidin levels and inflammatory markers IL-6 p0.61, CRP p0.82 and ferritin p0.27, vitamin D p0.13 and iron level p0.90 was not correlated. There was no correlation between hepcidin levels and ICU mortality p0.95 Conclusion: In this study, hepcidin levels were above normal limits in critically ill COVID-19 patients. However, our findings do not support the use of hepcidin, IL6, serum ferritin, and vitamin D levels in predicting COVID-19 mortality.

 Objectives: Aim of this study was to evaluate hepcidin levels and its correlation with inflammatory markers, vitamin D levels as well as its effects on intensive care unit ICU mortality in critically ill coronavirus disease-2019 COVID-19 patients. Materials and Methods: Adult patients those were admitted to pandemic ICU between March 1st, 2021 and May 17th 2021 were prospectively included to the study. Hepcidin levels and inflammatory markers on day 1, 2, 3 and 7, admission vitamin D levels, length of ICU stay and ICU mortality were recorded and analysed. Results: Median age of patients was 60.5 52.50-71.25 and 20 66.7 of them was male. It was observed that hepcidin levels and lymphocyte counts were increased significantly from day 1 to day 7 p0.01 and p0.01, respectively. In contrast, C-reactive protein CRP and procalsitonin levels were decreased from day 1 to day 7 p0.01 and p0.01, respectively. In the analysis admission hepcidin levels and inflammatory markers IL-6 p0.61, CRP p0.82 and ferritin p0.27, vitamin D p0.13 and iron level p0.90 was not correlated. There was no correlation between hepcidin levels and ICU mortality p0.95 Conclusion: In this study, hepcidin levels were above normal limits in critically ill COVID-19 patients. However, our findings do not support the use of hepcidin, IL6, serum ferritin, and vitamin D levels in predicting COVID-19 mortality.

 Amaç: Bu çalışmada amacımız kritik koronavirüs hastalığı-2019 COVID-19 hastalarında hepsidin düzeylerinin değişimi ve D vitamini düzeylerinin, enflamatuvar belirteçler, yoğun bakım ünitesi YBÜ yatış süresi ve yoğun bakım sonucu ile ilişkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: 1 Mart 2021 ile 17 Mayıs 2021 arasında hastanemiz pandemi YBÜde yatışı yapılan yetişkin hastalar prospektif olarak çalışmaya dahil edildi. Hastaların 1, 2, 3 ve 7. gün hepsidin düzeyleri ve diğer enflamatuvar belirteçleri, kabul vitamin D düzeyleri, yoğun bakım yatış süreleri ve yoğun bakım sonuçları kaydedilerek incelendi. Bulgular: Hastaların ortanca yaşı 60,5 52,50-71,25 ve 20si 66,7 erkekti. Hepsidin ve lenfosit sayısının 1. günden 7. güne olan süre içerisinde anlamlı olarak yükseldiği gözlendi p0,01 ve p0,01, sırasıyla. C-reaktif protein CRP ve prokalsitonin seviyelerinin ise 1. günden 7. güne olan süre içerisinde gerilediği gözlendi p0,01 ve p0,01, sırasıyla. Hastaların YBÜye kabulünde çalışılan hepsidin düzeyi ile enflamatuvar parametreler IL-6 p0,61, CRP p0,82 ve ferritin p0,27, D vitamini p0,13 ve demir düzeyi p0,90 arasında korelasyon saptanmadı. Hepsidin düzeyleri ile yoğun bakım mortalitesi arasında ilişki tespit edilemedi p0,95. Sonuç: Bu çalışma ile kritik COVID-19 hastalarında hepsidin düzeylerinin normal sınırlar üzerinde seyrettiği tespit edilmiştir. Ancak bulgularımız, hepsidin, IL6, serum ferritin ve D vitamini düzeylerinin COVID-19 mortalite tahmininde kullanımını destekler nitelikte değildir.

Makale detayları

The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients

Yazarlar:

Leyla Ferlicolak

Yayıncı:

Ankara University

Ana Başlıklar:

Internal Diseases

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.525-529

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349876

pISSN:

0365-8104

ICU

Hepcidin

MortalityYoğun Bakım

Hepsidin

Mortalite

Sayı

Makale detayları

The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients

Yazarlar: Leyla Ferlicolak

Yayıncı: Ankara University

Ana Başlıklar: Internal Diseases

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.525-529

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001349876

pISSN: 0365-8104

ICU

Hepcidin

MortalityYoğun Bakım

Hepsidin

Mortalite

Sayı

Yazarlar:

Leyla Ferlicolak

Yayıncı:

Ankara University

Ana Başlıklar:

Internal Diseases

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.525-529

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349876

pISSN:

0365-8104