Long-term Survival Outcomes of Early-stage Grade 1 and 2 EndometrioidType Endometrial Cancer Patients

Fazıl Avcı; Orhan Önder Eren; Ahmet Bilgi; Hamit Başaran; Murat Celik; Melek Caglayan; Cetin Celik

Makale detayları

Long-term Survival Outcomes of Early-stage Grade 1 and 2 EndometrioidType Endometrial Cancer Patients

Yazarlar:

Fazıl Avcı | Orhan Önder Eren | Ahmet Bilgi | Hamit Başaran | Murat Celik | Melek Caglayan | Cetin Celik

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 2, pp.232-238

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288882

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Aims: Early-stage endometrioid-type endometrial cancer EC has a favorable prognosis. The recurrence is still the biggest issue. There are differences in the literature in terms of treatment modalities in early-stage. We investigated long-term survival outcomes of early-stage grade 1 and 2 endometrioid-type EC patients. Methods: Out of 327 cases, 294 cases in stage 1 and 33 cases in stage 2 were evaluated. Age, stage, tumor size, histologic grade, degree of myometrial invasion, presence of lymphovascular invasion LVSI, peritoneal cytology positive, presence of recurrence, overall survival OS, and disease-free survival DFS between two groups were evaluated statistically. Results: The mean age of 327 patients was 64.010.0 years. Out of 327, 65.7 were 60 years, 90 were stage 1, 74.6 were grade 1, 1.8 had positive peritoneal cytology, 8.3 had LVSI and 86 had 50 myometrial invasion. Recurrence was detected in 6.4 of patients. 40.7 of patients received adjuvant radiotherapy. Only the adjuvant radiotherapy was found a significant association between two groups. Only presence of recurrence in terms of OS and DFS durations was a significant parameter in the regression analysis. Conclusions: Development of recurrence in early-stage endometrioid-type EC is the main prognostic predictor for survival. The early diagnosis and treatment of recurrence have a positive impact on the prognosis.

 Aims: Early-stage endometrioid-type endometrial cancer EC has a favorable prognosis. The recurrence is still the biggest issue. There are differences in the literature in terms of treatment modalities in early-stage. We investigated long-term survival outcomes of early-stage grade 1 and 2 endometrioid-type EC patients. Methods: Out of 327 cases, 294 cases in stage 1 and 33 cases in stage 2 were evaluated. Age, stage, tumor size, histologic grade, degree of myometrial invasion, presence of lymphovascular invasion LVSI, peritoneal cytology positive, presence of recurrence, overall survival OS, and disease-free survival DFS between two groups were evaluated statistically. Results: The mean age of 327 patients was 64.010.0 years. Out of 327, 65.7 were 60 years, 90 were stage 1, 74.6 were grade 1, 1.8 had positive peritoneal cytology, 8.3 had LVSI and 86 had 50 myometrial invasion. Recurrence was detected in 6.4 of patients. 40.7 of patients received adjuvant radiotherapy. Only the adjuvant radiotherapy was found a significant association between two groups. Only presence of recurrence in terms of OS and DFS durations was a significant parameter in the regression analysis. Conclusions: Development of recurrence in early-stage endometrioid-type EC is the main prognostic predictor for survival. The early diagnosis and treatment of recurrence have a positive impact on the prognosis.

 Aims: Early-stage endometrioid-type endometrial cancer EC has a favorable prognosis. The recurrence is still the biggest issue. There are differences in the literature in terms of treatment modalities in early-stage. We investigated long-term survival outcomes of early-stage grade 1 and 2 endometrioid-type EC patients. Methods: Out of 327 cases, 294 cases in stage 1 and 33 cases in stage 2 were evaluated. Age, stage, tumor size, histologic grade, degree of myometrial invasion, presence of lymphovascular invasion LVSI, peritoneal cytology positive, presence of recurrence, overall survival OS, and disease-free survival DFS between two groups were evaluated statistically. Results: The mean age of 327 patients was 64.010.0 years. Out of 327, 65.7 were 60 years, 90 were stage 1, 74.6 were grade 1, 1.8 had positive peritoneal cytology, 8.3 had LVSI and 86 had 50 myometrial invasion. Recurrence was detected in 6.4 of patients. 40.7 of patients received adjuvant radiotherapy. Only the adjuvant radiotherapy was found a significant association between two groups. Only presence of recurrence in terms of OS and DFS durations was a significant parameter in the regression analysis. Conclusions: Development of recurrence in early-stage endometrioid-type EC is the main prognostic predictor for survival. The early diagnosis and treatment of recurrence have a positive impact on the prognosis.

 Özet Amaç: Erken evre endometrioid tipi endometrial kanser EC iyi bir prognoza sahiptir. rekürrens hala en büyük sorundur. Literatürde erken evrede tedavi yöntemleri açısından farklılıklar vardır. Erken evre grade 1 ve 2 endometrioid tip endometriyum kanseri tanılı olgularda uzun dönem sonuçlarını retrospektif olarak araştırmaktır. Method: toplam 327 olgudan evre 1de 294 olgu ve evre 2de 33 olgu değerlendirildi. İki grup arasında yaş, evre, tümör çapı, grade, myometrial invazyon derecesi, lenfovasküler invazyon LVSI varlığı, periton sitolojisi pozitifliği, rekürrens varlığı, genel sağkalım OS ve hastalıksız sağkalım DFS süreleri istatistiki olarak değerlendirildi. Bulgular: Toplam 327 olgunun yaş ortalaması 64,010,0 yıl olrak hesaplandı. 327 olgudan 60 yaş ve üstü olgular 65,7, olguların 90ı evre 1 ve 74,6sı grade 1, periton sitolojisi 1,8 oranında pozitif, ve LVSI varlığı 8,3ünde pozitif, ve 50den az myometrial invazyon olguların 86,5inde saptandı. Rekürrens, olguların 6,4ünde saptandı. Olgulara adjuvan radyoterapi 40,7 oranında uygulandı. Olgular evre 1 ve evre 2 olarak karşılaştırıldığında sadece adjuvan radyoterapi tedavisi açısından anlamlı fark saptandı. OS ve DFS süreleri açısından regresyon analizinde sadece rekürrens varlığı anlamlı faktör olarak saptandı. Sonuç: Endometrioit tip endometrium kanserinde rekürrens gelişmesi sürvi açısından en önemli prognostik faktördür. Rekürrensin erken tanı ve tedavisi ile prognoz olumlu yönde etkilenmektedir.

Makale detayları

Long-term Survival Outcomes of Early-stage Grade 1 and 2 EndometrioidType Endometrial Cancer Patients

Yazarlar:

Fazıl Avcı | Orhan Önder Eren | Ahmet Bilgi | Hamit Başaran | Murat Celik | Melek Caglayan | Cetin Celik

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 2, pp.232-238

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288882

pISSN:

2602-3741

endometrial cancer

endometrioid type

recurrence

survivalendometrioid

endometriyal kanser

rekürrens

survi

Sayı

Makale detayları

Yazarlar: Fazıl Avcı | Orhan Önder Eren | Ahmet Bilgi | Hamit Başaran | Murat Celik | Melek Caglayan | Cetin Celik

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Genel Tıp Dergisi Vol.33 Issue 2, pp.232-238

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001288882

pISSN: 2602-3741

Sayı

Yazarlar:

Fazıl Avcı | Orhan Önder Eren | Ahmet Bilgi | Hamit Başaran | Murat Celik | Melek Caglayan | Cetin Celik

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 2, pp.232-238

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288882

pISSN:

2602-3741