Is Every Anti-Neutrophil Cytoplasmic Antibody (ANCA) Positivity Associated With Rheumatologic Disease?

Sevilay Batıbay; Tuğçe Bozkurt; Elif Dinçses Nas

Makale detayları

Is Every Anti-Neutrophil Cytoplasmic Antibody (ANCA) Positivity Associated With Rheumatologic Disease?

Yazarlar:

Sevilay Batıbay | Tuğçe Bozkurt | Elif Dinçses Nas

Yayıncı:

Kirikkale University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.27 Issue 1, pp.95-99

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001346077

pISSN:

2148-9645

Anahtar kelimeler:

Özet:

 Objective: We aimed to determine the rate of rheumatological disease detection in patients with anti-neutrophil cytoplasmic antibody ANCA and other conditions that lead to ANCA positivity other than ANCA-associated vasculitis AIV. Material and Methods: A retrospective evaluation was made of 76 adults aged 18-90 years who were evaluated for ANCA positivity at the Rheumatology Clinic of İstanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital between January 2023 and November 2024. Demographic parameters, ANCA titer and pattern, other laboratory values, and final diagnoses as a result of rheumatological evaluation of the patients were recorded. Patients diagnosed with rheumatological diseases were classified as group 1, and patients without were classified as group 2. Results: Seventy-six patients were evaluated retrospectively. Fifty-one 67 patients were female and 25 33 were male. The median age of the patients was 60.5 min-max:24-84. p- ANCA was detected in 40 patients 52.6, c-ANCA was detected in 10 13.2, MPO ANCA was positive in 21 22.6, and PR3 ANCA was positive in 33 43.6. 39 51.3 were diagnosed with rheumatologic disease, 23 of which were AIV. Infective endocarditis was detected in two patients, and lung cancer, tuberculosis, ulcerative colitis, and chronic urticaria were detected in one patient each. PR3 ANCA titer, sedimentation and CRP values were significantly higher in Group 1 than in Group 2 p0.0001, p0.017 and p0.005, respectively. Conclusion: ANCA test is not specific for AAV and can detect other inflammatory diseases and infectious pathologies. Therefore, ANCA is not a screening test and should be requested in cases of suspected vasculitis and evaluated with clinical findings.

 Objective: We aimed to determine the rate of rheumatological disease detection in patients with anti-neutrophil cytoplasmic antibody ANCA and other conditions that lead to ANCA positivity other than ANCA-associated vasculitis AIV. Material and Methods: A retrospective evaluation was made of 76 adults aged 18-90 years who were evaluated for ANCA positivity at the Rheumatology Clinic of İstanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital between January 2023 and November 2024. Demographic parameters, ANCA titer and pattern, other laboratory values, and final diagnoses as a result of rheumatological evaluation of the patients were recorded. Patients diagnosed with rheumatological diseases were classified as group 1, and patients without were classified as group 2. Results: Seventy-six patients were evaluated retrospectively. Fifty-one 67 patients were female and 25 33 were male. The median age of the patients was 60.5 min-max:24-84. p- ANCA was detected in 40 patients 52.6, c-ANCA was detected in 10 13.2, MPO ANCA was positive in 21 22.6, and PR3 ANCA was positive in 33 43.6. 39 51.3 were diagnosed with rheumatologic disease, 23 of which were AIV. Infective endocarditis was detected in two patients, and lung cancer, tuberculosis, ulcerative colitis, and chronic urticaria were detected in one patient each. PR3 ANCA titer, sedimentation and CRP values were significantly higher in Group 1 than in Group 2 p0.0001, p0.017 and p0.005, respectively. Conclusion: ANCA test is not specific for AAV and can detect other inflammatory diseases and infectious pathologies. Therefore, ANCA is not a screening test and should be requested in cases of suspected vasculitis and evaluated with clinical findings.

 Objective: We aimed to determine the rate of rheumatological disease detection in patients with anti-neutrophil cytoplasmic antibody ANCA and other conditions that lead to ANCA positivity other than ANCA-associated vasculitis AIV. Material and Methods: A retrospective evaluation was made of 76 adults aged 18-90 years who were evaluated for ANCA positivity at the Rheumatology Clinic of İstanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital between January 2023 and November 2024. Demographic parameters, ANCA titer and pattern, other laboratory values, and final diagnoses as a result of rheumatological evaluation of the patients were recorded. Patients diagnosed with rheumatological diseases were classified as group 1, and patients without were classified as group 2. Results: Seventy-six patients were evaluated retrospectively. Fifty-one 67 patients were female and 25 33 were male. The median age of the patients was 60.5 min-max:24-84. p- ANCA was detected in 40 patients 52.6, c-ANCA was detected in 10 13.2, MPO ANCA was positive in 21 22.6, and PR3 ANCA was positive in 33 43.6. 39 51.3 were diagnosed with rheumatologic disease, 23 of which were AIV. Infective endocarditis was detected in two patients, and lung cancer, tuberculosis, ulcerative colitis, and chronic urticaria were detected in one patient each. PR3 ANCA titer, sedimentation and CRP values were significantly higher in Group 1 than in Group 2 p0.0001, p0.017 and p0.005, respectively. Conclusion: ANCA test is not specific for AAV and can detect other inflammatory diseases and infectious pathologies. Therefore, ANCA is not a screening test and should be requested in cases of suspected vasculitis and evaluated with clinical findings.

 Amaç: Anti-nötrofil sitoplazmik antikor ANCA saptanan hastalarda romatolojik hastalık saptanma oranını ve ANCA ilişkili vaskülit AİV dışında ANCA pozitifliğine yol açan diğer durumları belirlemeyi amaçladık. Gereç ve Yöntemler: İstanbul Medeniyet Üniversitesi, Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi Romatoloji polikliniğinde Ocak 2023-Kasım 2024 tarihleri arasında ANCA pozitifliği nedeniyle değerlendirilen 18-90 yaş aralığındaki 76 erişkin geriye dönük değerlendirildi. Hastaların demografik verileri, ANCA titresi ve paterni, diğer laboratuvar parametreleri, romatolojik olarak değerlendirilmesi neticesindeki nihai tanıları kaydedildi. Romatolojik hastalık tanısı alan hastalar grup 1, almayanlar ise grup 2 olarak sınıflandırıldı. Bulgular: 76 hasta retrospektif olarak değerlendirildi. Hastaların 51i 67 kadın, 25i 33 erkek idi. Hastaların ortanca yaşı 60,5ti min-max:24-84. 40 52,6 hastada p- ANCA, 10 13,2 hastada c-ANCA saptanırken, 21inde 22,6 MPO ANCA, 33ünde 43,6 PR3 ANCA pozitifti. 39u 51,3 romatolojik hastalık tanısı aldı, bunların 23ü 30,3 AİV idi. İki enfektif endokardit, birer hastada akciğer kanseri, tüberküloz, ülseratif kolit ve kronik ürtiker saptandı. Grup 1de PR3 ANCA titresi, sedimentasyon ve CRP değerleri Grup 2ye göre anlamlı olarak daha yüksekti sırasıyla p0,0001, p0,017 ve p0,005. Sonuç: ANCA testi AİV için spesifik olmayıp diğer inflamatuar hastalıklarda, enfektif patolojilerde tespit edebilir. O nedenle ANCA bir tarama testi olmayıp vaskülit şüphesi olan olgularda istenmeli ve klinik bulgular eşliğinde değerlendirilmelidir.

Makale detayları

Is Every Anti-Neutrophil Cytoplasmic Antibody (ANCA) Positivity Associated With Rheumatologic Disease?

Yazarlar:

Sevilay Batıbay | Tuğçe Bozkurt | Elif Dinçses Nas

Yayıncı:

Kirikkale University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.27 Issue 1, pp.95-99

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001346077

pISSN:

2148-9645

Antineutrophil cytoplasmic antibodies

c-ANCA

p-ANCA

anti-neutrophil cytoplasmic antibody-associated vasculitisAntinötrofil sitoplazmik antikor

c-ANCA

p-ANCA

anti-nötrofil sitoplazmik antikor-ilişkili vaskülit

Sayı

Makale detayları

Yazarlar: Sevilay Batıbay | Tuğçe Bozkurt | Elif Dinçses Nas

Yayıncı: Kirikkale University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.27 Issue 1, pp.95-99

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001346077

pISSN: 2148-9645

Sayı

Yazarlar:

Sevilay Batıbay | Tuğçe Bozkurt | Elif Dinçses Nas

Yayıncı:

Kirikkale University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Vol.27 Issue 1, pp.95-99

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001346077

pISSN:

2148-9645