The Predictive Factors of Malignancy in Follicular Lesion of Undeterminated Significance

Samet Şahin; Hikmet Pehlevan Özel; Yunus Yuksek; Tanju Tütüncü

Makale detayları

The Predictive Factors of Malignancy in Follicular Lesion of Undeterminated Significance

Yazarlar:

Samet Şahin | Hikmet Pehlevan Özel | Yunus Yuksek | Tanju Tütüncü

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

Cerrahi

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 1, pp.15-18

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287204

pISSN:

2148-8118

Anahtar kelimeler:

Özet:

 Follicular lesion of undetermined significance FLUS is defined in the same Group III with the atypia of undetermined significance according to Bethesda Classification but these subgroups have different malignancy rates and tumor characteristics according to the studies. In this study, the aim was to evaluate the preoperative clinicopathologic features of the patients with cytological Bethesda Category IIIFLUS thyroid nodules. The 44 patients were divided into two groups based on fine needle aspiration cytology FNAC results as benign pB and malignant pM and compared the preoperative clinical, ultrasonographic findings and FNAC results of two groups. According to the univariate analyses the presence of hiopechogenicity and presence of microcalcification are found to be significantly higher in malignancy p0.05 for all. Also, the presence of microcalcifications p0.048, and hypoechogenicity p0.014 were found to be independent risk factors for malignancy according to logistic regression analysis. In patients with FLUS, it should be remembered that the incidence of malignancy increases and treatment should be considered in the forefront of surgery instead of recurrent FNAC in the presence of hypoechogenicity and microcalcification in ultrasonography, and in patients with nuclear membrane irregularity according to FNAC.

 Follicular lesion of undetermined significance FLUS is defined in the same Group III with the atypia of undetermined significance according to Bethesda Classification but these subgroups have different malignancy rates and tumor characteristics according to the studies. In this study, the aim was to evaluate the preoperative clinicopathologic features of the patients with cytological Bethesda Category IIIFLUS thyroid nodules. The 44 patients were divided into two groups based on fine needle aspiration cytology FNAC results as benign pB and malignant pM and compared the preoperative clinical, ultrasonographic findings and FNAC results of two groups. According to the univariate analyses the presence of hiopechogenicity and presence of microcalcification are found to be significantly higher in malignancy p0.05 for all. Also, the presence of microcalcifications p0.048, and hypoechogenicity p0.014 were found to be independent risk factors for malignancy according to logistic regression analysis. In patients with FLUS, it should be remembered that the incidence of malignancy increases and treatment should be considered in the forefront of surgery instead of recurrent FNAC in the presence of hypoechogenicity and microcalcification in ultrasonography, and in patients with nuclear membrane irregularity according to FNAC.

 Follicular lesion of undetermined significance FLUS is defined in the same Group III with the atypia of undetermined significance according to Bethesda Classification but these subgroups have different malignancy rates and tumor characteristics according to the studies. In this study, the aim was to evaluate the preoperative clinicopathologic features of the patients with cytological Bethesda Category IIIFLUS thyroid nodules. The 44 patients were divided into two groups based on fine needle aspiration cytology FNAC results as benign pB and malignant pM and compared the preoperative clinical, ultrasonographic findings and FNAC results of two groups. According to the univariate analyses the presence of hiopechogenicity and presence of microcalcification are found to be significantly higher in malignancy p0.05 for all. Also, the presence of microcalcifications p0.048, and hypoechogenicity p0.014 were found to be independent risk factors for malignancy according to logistic regression analysis. In patients with FLUS, it should be remembered that the incidence of malignancy increases and treatment should be considered in the forefront of surgery instead of recurrent FNAC in the presence of hypoechogenicity and microcalcification in ultrasonography, and in patients with nuclear membrane irregularity according to FNAC.

 Önemi belirsiz folliküler lezyon ÖBFL Bethesda Sınıflamasına göre önemi belirsiz atipi ile aynı üçüncü grupta tanımlanmıştır, ancak bu alt gruplar yapılan çalışmalara göre farklı malignite oranlarına ve tümör özelliklerine sahiptir. Bu çalışmada sitolojik olarak Bethesda Kategori IIIÖBFL tiroid nodüllü hastaların preoperatif klinikopatolojik özelliklerinin değerlendirilmesi amaçlandı. 44 hasta ince iğne aspirasyon sitolojisi İİAS sonuçlarına göre benign pB ve malign pM olarak iki gruba ayrıldı ve iki grubun ameliyat öncesi klinik, ultrasonografik bulguları ve İİAS sonuçları karşılaştırıldı. Tek değişkenli analizlere göre İİASye göre hiopekojenite, mikrokalsifikasyon varlığı ve düzensiz çekirdek varlığı malignitede anlamlı olarak daha yüksek bulundu tümü için p0,05. Ayrıca mikrokalsifikasyonlar p0,048 ve hipoekojenite p0,014 lojistik regresyon analizine göre malignite için bağımsız risk faktörleri olarak bulundu. ÖBFLli hastalarda ultrasonografide hipoekojenite ve mikrokalsifikasyon varlığında, tekrarlayan İİAS yerine malignite insidansının arttığı ve cerrahinin ön planda düşünülmesi gerektiği unutulmamalıdır.

Makale detayları

The Predictive Factors of Malignancy in Follicular Lesion of Undeterminated Significance

Yazarlar:

Samet Şahin | Hikmet Pehlevan Özel | Yunus Yuksek | Tanju Tütüncü

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

Cerrahi

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 1, pp.15-18

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287204

pISSN:

2148-8118

Malignancy

Follicular Lesion of Undetermined Significance

Predictive Factors

Malignite

Önemi Belirsiz Foliküler Lezyon

Prediktif Faktörler

Sayı

Makale detayları

The Predictive Factors of Malignancy in Follicular Lesion of Undeterminated Significance

Yazarlar: Samet Şahin | Hikmet Pehlevan Özel | Yunus Yuksek | Tanju Tütüncü

Yayıncı: Mugla Sitki Kocman University

Ana Başlıklar: Cerrahi

Dergi: Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 1, pp.15-18

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001287204

pISSN: 2148-8118

Malignancy

Follicular Lesion of Undetermined Significance

Predictive Factors

Malignite

Önemi Belirsiz Foliküler Lezyon

Prediktif Faktörler

Sayı

Yazarlar:

Samet Şahin | Hikmet Pehlevan Özel | Yunus Yuksek | Tanju Tütüncü

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

Cerrahi

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 1, pp.15-18

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287204

pISSN:

2148-8118