Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Nur Damla Korkmaz; Birsen Elibol; Seda Süsgün; Ceyhun Toruntay; Alişan Bayrakoğlu; Mazlum Yuzgulec; Zihni Elagoz; Ayşegül Yabacı Tak; Emrah Yücesan; Ferda İlgen Uslu; Gülsen Babacan Yıldız; Azize Esra Başar Gürsoy; Fahri Akbaş; Bilge Sümbül

Makale detayları

Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Yazarlar:

Nur Damla Korkmaz | Birsen Elibol | Seda Süsgün | Ceyhun Toruntay | Alişan Bayrakoğlu | Mazlum Yuzgulec | Zihni Elagoz | Ayşegül Yabacı Tak | Emrah Yücesan | Ferda İlgen Uslu | Gülsen Babacan Yıldız | Azize Esra Başar Gürsoy | Fahri Akbaş | Bilge Sümbül

Yayıncı:

Istanbul University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Experimed Vol.14 Issue 2, pp.92-101

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328772

pISSN:

2667-5846

Anahtar kelimeler:

Özet:

 Objective: Neuroinflammation and blood-brain barrier BBB dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimers Disease AD, Parkinsons Disease PD, Multiple Sclerosis MS, and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide LPS, the largest endotoxin, and brain-derived neurotrophic factor BDNF in patients blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein CRP, BDNF, and lactate dehydrogenase LDH levels across conditions. LPS was positively correlated with CRP levels in epilepsy r0.753, p0.002. Additionally, BDNF was negatively correlated with CRP in PD patients r-0.53, p0.042. Moreover, a negative correlation was found between LPS and LDH in AD patients r-0.521, p0.047. Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

 Objective: Neuroinflammation and blood-brain barrier BBB dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimers Disease AD, Parkinsons Disease PD, Multiple Sclerosis MS, and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide LPS, the largest endotoxin, and brain-derived neurotrophic factor BDNF in patients blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein CRP, BDNF, and lactate dehydrogenase LDH levels across conditions. LPS was positively correlated with CRP levels in epilepsy r0.753, p0.002. Additionally, BDNF was negatively correlated with CRP in PD patients r-0.53, p0.042. Moreover, a negative correlation was found between LPS and LDH in AD patients r-0.521, p0.047. Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

 Objective: Neuroinflammation and blood-brain barrier BBB dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimers Disease AD, Parkinsons Disease PD, Multiple Sclerosis MS, and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide LPS, the largest endotoxin, and brain-derived neurotrophic factor BDNF in patients blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein CRP, BDNF, and lactate dehydrogenase LDH levels across conditions. LPS was positively correlated with CRP levels in epilepsy r0.753, p0.002. Additionally, BDNF was negatively correlated with CRP in PD patients r-0.53, p0.042. Moreover, a negative correlation was found between LPS and LDH in AD patients r-0.521, p0.047. Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

 Objective: Neuroinflammation and blood-brain barrier BBB dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimers Disease AD, Parkinsons Disease PD, Multiple Sclerosis MS, and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide LPS, the largest endotoxin, and brain-derived neurotrophic factor BDNF in patients blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein CRP, BDNF, and lactate dehydrogenase LDH levels across conditions. LPS was positively correlated with CRP levels in epilepsy r0.753, p0.002. Additionally, BDNF was negatively correlated with CRP in PD patients r-0.53, p0.042. Moreover, a negative correlation was found between LPS and LDH in AD patients r-0.521, p0.047. Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

Makale detayları

Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Yazarlar:

Nur Damla Korkmaz | Birsen Elibol | Seda Süsgün | Ceyhun Toruntay | Alişan Bayrakoğlu | Mazlum Yuzgulec | Zihni Elagoz | Ayşegül Yabacı Tak | Emrah Yücesan | Ferda İlgen Uslu | Gülsen Babacan Yıldız | Azize Esra Başar Gürsoy | Fahri Akbaş | Bilge Sümbül

Yayıncı:

Istanbul University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Experimed Vol.14 Issue 2, pp.92-101

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328772

pISSN:

2667-5846

Brain-derived neurotrophic factor

lipopolysaccharide

neuroinflammation

neurological diseases

biomarker

Sayı

Makale detayları

Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Yazarlar: Nur Damla Korkmaz | Birsen Elibol | Seda Süsgün | Ceyhun Toruntay | Alişan Bayrakoğlu | Mazlum Yuzgulec | Zihni Elagoz | Ayşegül Yabacı Tak | Emrah Yücesan | Ferda İlgen Uslu | Gülsen Babacan Yıldız | Azize Esra Başar Gürsoy | Fahri Akbaş | Bilge Sümbül

Yayıncı: Istanbul University

Ana Başlıklar: Biochemistry and Cell Biology (Other)

Dergi: Experimed Vol.14 Issue 2, pp.92-101

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001328772

pISSN: 2667-5846

Brain-derived neurotrophic factor

lipopolysaccharide

neuroinflammation

neurological diseases

biomarker

Sayı

Yazarlar:

Nur Damla Korkmaz | Birsen Elibol | Seda Süsgün | Ceyhun Toruntay | Alişan Bayrakoğlu | Mazlum Yuzgulec | Zihni Elagoz | Ayşegül Yabacı Tak | Emrah Yücesan | Ferda İlgen Uslu | Gülsen Babacan Yıldız | Azize Esra Başar Gürsoy | Fahri Akbaş | Bilge Sümbül

Yayıncı:

Istanbul University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Experimed Vol.14 Issue 2, pp.92-101

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328772

pISSN:

2667-5846