Investigation of the Effects of Hesperidin on Bisphenol-A Induced Neurotoxicity in Rats

Burak Batuhan Laçin; Fikret Çelebi

Makale detayları

Investigation of the Effects of Hesperidin on Bisphenol-A Induced Neurotoxicity in Rats

Yazarlar:

Burak Batuhan Laçin | Fikret Çelebi

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Veterinary Sciences and Practices Vol.19 Issue 1, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316090

pISSN:

2822-3608

Anahtar kelimeler:

Özet:

 Bisphenol A BPA is an adhesive substance used in the production of food packaging, electronic devices, dental sealants and polycarbonate plastics. This substance, which can leak into products during industrial processes, can be taken into the body through contact or consumption. BPA causes oxidative damage in the body and toxicity to organs. This study was conducted on 52 male rats. The rats were randomly distributed into 4 separate groups, with 13 animals in each. Experiment groups were formed as follows: Control: 1 ml of olive oil was administered intragastrically for 14 days. Hesperidin HESP: HESP was administered intragastrically at a dose of 50 mgkg for 14 days. BPA: BPA dissolved in olive oil was administered intragastrically at a dose of 100 mgkg for 14 days. BPAHESP: BPA at a dose of 100 mgkg and HESP at a dose of 50 mgkg were administered intragastrically for 14 days. Brain tissue samples from the rats were collected on the 15th day of the experiment while the rats were under sevoflurane anesthesia. Histopathological and biochemical analyzes were performed on the brain tissues of the rats. As a result of the study, it was observed that HESP had a protective effect on BPA-induced neurotoxicity in rats and triggered the antioxidant mechanism responsible for defense in the cell. It was opined that the degenerative and necrotic tissue damage caused by BPA in the brain tissue decreased with the effect of Hesperidin.

 Bisphenol A BPA is an adhesive substance used in the production of food packaging, electronic devices, dental sealants and polycarbonate plastics. This substance, which can leak into products during industrial processes, can be taken into the body through contact or consumption. BPA causes oxidative damage in the body and toxicity to organs. This study was conducted on 52 male rats. The rats were randomly distributed into 4 separate groups, with 13 animals in each. Experiment groups were formed as follows: Control: 1 ml of olive oil was administered intragastrically for 14 days. Hesperidin HESP: HESP was administered intragastrically at a dose of 50 mgkg for 14 days. BPA: BPA dissolved in olive oil was administered intragastrically at a dose of 100 mgkg for 14 days. BPAHESP: BPA at a dose of 100 mgkg and HESP at a dose of 50 mgkg were administered intragastrically for 14 days. Brain tissue samples from the rats were collected on the 15th day of the experiment while the rats were under sevoflurane anesthesia. Histopathological and biochemical analyzes were performed on the brain tissues of the rats. As a result of the study, it was observed that HESP had a protective effect on BPA-induced neurotoxicity in rats and triggered the antioxidant mechanism responsible for defense in the cell. It was opined that the degenerative and necrotic tissue damage caused by BPA in the brain tissue decreased with the effect of Hesperidin.

 Bisphenol A BPA is an adhesive substance used in the production of food packaging, electronic devices, dental sealants and polycarbonate plastics. This substance, which can leak into products during industrial processes, can be taken into the body through contact or consumption. BPA causes oxidative damage in the body and toxicity to organs. This study was conducted on 52 male rats. The rats were randomly distributed into 4 separate groups, with 13 animals in each. Experiment groups were formed as follows: Control: 1 ml of olive oil was administered intragastrically for 14 days. Hesperidin HESP: HESP was administered intragastrically at a dose of 50 mgkg for 14 days. BPA: BPA dissolved in olive oil was administered intragastrically at a dose of 100 mgkg for 14 days. BPAHESP: BPA at a dose of 100 mgkg and HESP at a dose of 50 mgkg were administered intragastrically for 14 days. Brain tissue samples from the rats were collected on the 15th day of the experiment while the rats were under sevoflurane anesthesia. Histopathological and biochemical analyzes were performed on the brain tissues of the rats. As a result of the study, it was observed that HESP had a protective effect on BPA-induced neurotoxicity in rats and triggered the antioxidant mechanism responsible for defense in the cell. It was opined that the degenerative and necrotic tissue damage caused by BPA in the brain tissue decreased with the effect of Hesperidin.

 Bisfenol A BPA, gıda ambalajı, elektronik cihazlar, diş dolguları ve polikarbon plastiklerin üretiminde kullanılan yapışkan bir maddedir. Bu madde, endüstriyel işlemler sırasında ürünlere sızabilir ve temas veya tüketim yoluyla vücuda alınabilir. BPA, vücutta oksidatif hasara ve organlara toksisiteye neden olabilir. Bu çalışma, 52 erkek sıçan üzerinde gerçekleştirilmiştir. Sıçanlar, her birinde 13 hayvan bulunan 4 ayrı gruba rastgele dağıtılmıştır. Deney grupları şu şekilde oluşturuldu: Kontrol: 1 ml zeytinyağı, 14 gün boyunca intragastrik olarak uygulandı. BPA maruz kalan gruplara HESP dozunda 100 mgkg intragastrik uygulama ile verildi. HESP: HESP, 50 mgkg dozunda 14 gün boyunca intragastrik olarak uygulandı. BPA: BPA, zeytinyağında çözülmüş olarak 100 mgkg dozunda 14 gün boyunca intragastrik olarak uygulandı. BPAHESP: BPA, 100 mgkg dozunda ve HESP, 50 mgkg dozunda 14 gün boyunca intragastrik olarak uygulandı. Deneyin 15. gününde, sıçanlar sevofluran anestezisi altındayken sıçanlardan beyin dokusu örnekleri toplandı. Sıçanların beyin dokularında histopatolojik ve biyokimyasal analizler yapıldı. Çalışma sonucunda, HESPnin BPA tarafından indüklenen nörotoksisite üzerinde koruyucu bir etkisi olduğu ve hücre savunmasından sorumlu antioksidan mekanizmayı tetiklediği gözlemlendi. BPAnın beyin dokusunda neden olduğu dejeneratif ve nekrotik doku hasarının, HESPnin etkisi ile azaldığı düşünülmüştür.

Makale detayları

Investigation of the Effects of Hesperidin on Bisphenol-A Induced Neurotoxicity in Rats

Yazarlar:

Burak Batuhan Laçin | Fikret Çelebi

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Veterinary Sciences and Practices Vol.19 Issue 1, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316090

pISSN:

2822-3608

Bisphenol A

hesperidin

malondialdehyde

neurotoxicity

ratBisphenol A

hesperidin

malondialdehit

nörotoksisite

rat

Sayı

Makale detayları

Yazarlar: Burak Batuhan Laçin | Fikret Çelebi

Yayıncı: Ataturk University

Ana Başlıklar: Veteriner Bilimleri (Diğer)

Dergi: Veterinary Sciences and Practices Vol.19 Issue 1, pp.17-24

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001316090

pISSN: 2822-3608

Sayı

Yazarlar:

Burak Batuhan Laçin | Fikret Çelebi

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Veterinary Sciences and Practices Vol.19 Issue 1, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316090

pISSN:

2822-3608