Metabolic syndrome as a risk factor in contrast-induced nephropathy

Belma Özlem Tural Balsak; Şehmus Özmen; Davut Akın; Mehmet Emin Yılmaz

Makale detayları

Metabolic syndrome as a risk factor in contrast-induced nephropathy

Yazarlar:

Belma Özlem Tural Balsak | Şehmus Özmen | Davut Akın | Mehmet Emin Yılmaz

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.476-482

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349464

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: The expanding use of contrast media has made contrast-induced acute kidney injury CI-AKI a cause of acute renal failure. This study investigated the relationship between metabolic syndrome MS, insulin resistance, and contrast-induced acute kidney injury. Methods: This study encompassed 94 hospitalized patients 73 male with creatinine levels of 1.0 and above who underwent contrast-enhanced computed tomography for various reasons in the internal medicine clinics of Dicle University Faculty of Medicine. Patients whose creatinine levels were routinely measured before and 48 hours after tomography and whose anamnesis information was sufficient for the International Diabetes Federation metabolic syndrome criteria were retrospectively included in the study. HOMA-IR values were calculated. Results: CI-AKI developed in 10 10.6 patients out of 94. MS was identified in 60 of the group that developed CI-AKI and 38.1 that did not. Insulin resistance was observed in 30 of the group that developed CI-AKI and 17.9 that did not. Despite the observed difference, it did not achieve statistical significance. Considerable differences were found between the two groups regarding albumin, urea, creatinine, uric acid, C-reactive protein, and hemoglobin levels. CI-AKI was significantly more common in individuals with low creatinine clearance and in those with creatinine 1.3 mgdl. Conclusion: Our study showed that a higher rate of patients with MS was detected in the group with CI-AKI. MS has been accused of being a risk factor for CI-AKI. Therefore, caution should be exercised when administering contrast to patients with MS.

 Aims: The expanding use of contrast media has made contrast-induced acute kidney injury CI-AKI a cause of acute renal failure. This study investigated the relationship between metabolic syndrome MS, insulin resistance, and contrast-induced acute kidney injury. Methods: This study encompassed 94 hospitalized patients 73 male with creatinine levels of 1.0 and above who underwent contrast-enhanced computed tomography for various reasons in the internal medicine clinics of Dicle University Faculty of Medicine. Patients whose creatinine levels were routinely measured before and 48 hours after tomography and whose anamnesis information was sufficient for the International Diabetes Federation metabolic syndrome criteria were retrospectively included in the study. HOMA-IR values were calculated. Results: CI-AKI developed in 10 10.6 patients out of 94. MS was identified in 60 of the group that developed CI-AKI and 38.1 that did not. Insulin resistance was observed in 30 of the group that developed CI-AKI and 17.9 that did not. Despite the observed difference, it did not achieve statistical significance. Considerable differences were found between the two groups regarding albumin, urea, creatinine, uric acid, C-reactive protein, and hemoglobin levels. CI-AKI was significantly more common in individuals with low creatinine clearance and in those with creatinine 1.3 mgdl. Conclusion: Our study showed that a higher rate of patients with MS was detected in the group with CI-AKI. MS has been accused of being a risk factor for CI-AKI. Therefore, caution should be exercised when administering contrast to patients with MS.

 Aims: The expanding use of contrast media has made contrast-induced acute kidney injury CI-AKI a cause of acute renal failure. This study investigated the relationship between metabolic syndrome MS, insulin resistance, and contrast-induced acute kidney injury. Methods: This study encompassed 94 hospitalized patients 73 male with creatinine levels of 1.0 and above who underwent contrast-enhanced computed tomography for various reasons in the internal medicine clinics of Dicle University Faculty of Medicine. Patients whose creatinine levels were routinely measured before and 48 hours after tomography and whose anamnesis information was sufficient for the International Diabetes Federation metabolic syndrome criteria were retrospectively included in the study. HOMA-IR values were calculated. Results: CI-AKI developed in 10 10.6 patients out of 94. MS was identified in 60 of the group that developed CI-AKI and 38.1 that did not. Insulin resistance was observed in 30 of the group that developed CI-AKI and 17.9 that did not. Despite the observed difference, it did not achieve statistical significance. Considerable differences were found between the two groups regarding albumin, urea, creatinine, uric acid, C-reactive protein, and hemoglobin levels. CI-AKI was significantly more common in individuals with low creatinine clearance and in those with creatinine 1.3 mgdl. Conclusion: Our study showed that a higher rate of patients with MS was detected in the group with CI-AKI. MS has been accused of being a risk factor for CI-AKI. Therefore, caution should be exercised when administering contrast to patients with MS.

 AMAÇ: Kontrast maddenin artan miktarda kullanımı, kontrast madde nefropatisini Akut Böbrek Yetmezliğinin giderek sık rastlanan bir nedeni haline getirmiştir. Kontrast madde nefropatisi için, önceden var olan böbrek yetmezliği, diyabet, hipovolemi, ileri yaş, kalp yetmezliği, fazla kontrast madde kullanımı, nefrotoksik ilaçlar risk faktörlerini oluşturmaktadır. Metabolik Sendromun kontrast madde nefropatisi için risk faktörü olup olmadığı ile ilgili literatürde az sayıda çalışma yapılmış ve risk faktörü olduğu belirlenmiştir. Çalışmamızda, metabolik sendrom ve insülin direnci ile kontrast madde nefropatisi arasındaki ilişki incelenmiştir. MATERYAL VE METOD: Bu çalışmaya Dicle Üniversitesi Tıp Fakültesi dahili bilimler kliniklerinde yatan ve herhangi bir nedenle kontrastlı bilgisayarlı tomografi çekilen 94 hasta dahil edildi. Çalışmaya kreatinin seviyesi 1.0 ve üzerindeki hastalar alındı. Hastaların tomografi öncesi ve tomografiden 48 saat sonraki kreatinin değerlerine bakılarak kontrast madde nefropatisi gelişen hastalar tespit edildi. Tüm hastalar metabolik sendrom yönünden IDF kriterleri kullanılarak değerlendirildi. HOMA-IR değerleri hesaplandı. BULGULAR: Çalışmaya 73 erkek, 21 kadın hasta alındı. Toplam 94 hastanın 10unda kontrast madde nefropatisi gelişti. Kontrast madde nefropatisi gelişen grubun 60 ında, gelişmeyen grubun 38,1inde metabolik sendrom saptandı. İnsülin direnci kontrast madde nefropatisi gelişen grupta 30, gelişmeyen grupta 17,9 oranında görüldü. Hasta sayısının azlığından dolayı aradaki bu fark istatistiksel anlamlılığa ulaşmadı. Hastaların değerlendirilen albümin, üre, kreatinin, ürik asit, CRP, hemoglobin değerleri arasında kontrast madde nefropatisi gelişen ve gelişmeyen gruplar arasında anlamlı fark saptandı. İki grup arasında bazal kreatinin klirensleri ve kreatinin 1.3 olanlarda belirgin fark saptandı. Renal fonksiyon bozukluğunun kontrast madde nefropatisiyle ilişkili olduğu görüldü. SONUÇ: Kontrast madde nefropatisi görüntüleme tekniklerinin gelişmesiyle birlikte daha sık görülmeye başlandı. Son yıllarda metabolik sendrom da kontrast madde nefropatisi risk faktörü olarak suçlanmaktadır. Sonuç olarak, bu çalışmada kontrast madde nefropatisi gelişen grupta daha yüksek oranda metabolik sendromlu hasta saptanmasına rağmen bu fark istatistiki anlamlılığa ulaşmamıştır. Ancak yine de oranın yüksek olması nedeniyle metabolik sendromlu hastalara kontrast madde verilirken dikkatli olunmalıdır.

Makale detayları

Metabolic syndrome as a risk factor in contrast-induced nephropathy

Yazarlar:

Belma Özlem Tural Balsak | Şehmus Özmen | Davut Akın | Mehmet Emin Yılmaz

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.476-482

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349464

pISSN:

2636-8579

Contrast-induced acute kidney injury

insulin resistance

metabolic syndromeKontrast Madde Nefropatisi

Metabolik Sendrom

İnsülin Direnci

Sayı

Makale detayları

Metabolic syndrome as a risk factor in contrast-induced nephropathy

Yazarlar: Belma Özlem Tural Balsak | Şehmus Özmen | Davut Akın | Mehmet Emin Yılmaz

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: İç Hastalıkları

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.476-482

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349464

pISSN: 2636-8579

Contrast-induced acute kidney injury

insulin resistance

metabolic syndromeKontrast Madde Nefropatisi

Metabolik Sendrom

İnsülin Direnci

Sayı

Yazarlar:

Belma Özlem Tural Balsak | Şehmus Özmen | Davut Akın | Mehmet Emin Yılmaz

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.476-482

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349464

pISSN:

2636-8579