Investigation Of Causing Microorganisms And Antimicrobial Sensitivity Patterns In Diabetic Foot Wounds

Aynur Ismayıl; Bayram Çolak; Serdar Yormaz; Hatice Türk Dağı; Salih Maçin

Makale detayları

Investigation Of Causing Microorganisms And Antimicrobial Sensitivity Patterns In Diabetic Foot Wounds

Yazarlar:

Aynur Ismayıl | Bayram Çolak | Serdar Yormaz | Hatice Türk Dağı | Salih Maçin

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.35 Issue 2, pp.276-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345141

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Abstract BackgroundAims: Diabetic foot is the clinical term describing a series of diabetes-related lower extremity complications such as ulceration, infection, and gangrene. Aim of the study is to prospectively investigate the causative aerobic bacteria in diabetic foot ulcer samples, as well as anaerobic bacteria and fungi, which are thought to have an important place in diabetic foot infections. At the same time, the antimicrobial susceptibility of the causative microorganisms obtained from the culture will be investigated. Methods: 59 samples taken from 50 patients with type 2 Diabetes Mellitus were included in the study. The BD Phoenix TM automated system was used for species-level identification of microorganisms and antimicrobial susceptibility testing. The antimicrobial susceptibility of anaerobic microorganisms was tested with the gradient gradient test method. Results: It was determined that the most common 65 agent in DFI was Gram-negative aerobic bacteria and the majority of them 65 were multidrug resistant. The most common cause of monomicrobial infection is Staphylococcus aureus and the MRSA rate was found to be 27. The results of the study showed that vancomycin, teicoplanin and linezolid were the most effective antibiotics against Gram-positive agents. The most effective antibiotics against gram-negative agents were found to be ceftolozanetazobactam, piperacillintazobactam, meropenem, ertapenem, colistin and amikacin. Conclusions: Considering that the majority of Gram-negative agents consist of multidrug resistant microorganisms, the importance of prudent antibiotic use is once again increasing. It should be taken into account that diabetes is a disease that is 80 preventable with lifestyle changes, and the importance of increasing public awareness about healthy living should be emphasized.

 Abstract BackgroundAims: Diabetic foot is the clinical term describing a series of diabetes-related lower extremity complications such as ulceration, infection, and gangrene. Aim of the study is to prospectively investigate the causative aerobic bacteria in diabetic foot ulcer samples, as well as anaerobic bacteria and fungi, which are thought to have an important place in diabetic foot infections. At the same time, the antimicrobial susceptibility of the causative microorganisms obtained from the culture will be investigated. Methods: 59 samples taken from 50 patients with type 2 Diabetes Mellitus were included in the study. The BD Phoenix TM automated system was used for species-level identification of microorganisms and antimicrobial susceptibility testing. The antimicrobial susceptibility of anaerobic microorganisms was tested with the gradient gradient test method. Results: It was determined that the most common 65 agent in DFI was Gram-negative aerobic bacteria and the majority of them 65 were multidrug resistant. The most common cause of monomicrobial infection is Staphylococcus aureus and the MRSA rate was found to be 27. The results of the study showed that vancomycin, teicoplanin and linezolid were the most effective antibiotics against Gram-positive agents. The most effective antibiotics against gram-negative agents were found to be ceftolozanetazobactam, piperacillintazobactam, meropenem, ertapenem, colistin and amikacin. Conclusions: Considering that the majority of Gram-negative agents consist of multidrug resistant microorganisms, the importance of prudent antibiotic use is once again increasing. It should be taken into account that diabetes is a disease that is 80 preventable with lifestyle changes, and the importance of increasing public awareness about healthy living should be emphasized.

 Abstract BackgroundAims: Diabetic foot is the clinical term describing a series of diabetes-related lower extremity complications such as ulceration, infection, and gangrene. Aim of the study is to prospectively investigate the causative aerobic bacteria in diabetic foot ulcer samples, as well as anaerobic bacteria and fungi, which are thought to have an important place in diabetic foot infections. At the same time, the antimicrobial susceptibility of the causative microorganisms obtained from the culture will be investigated. Methods: 59 samples taken from 50 patients with type 2 Diabetes Mellitus were included in the study. The BD Phoenix TM automated system was used for species-level identification of microorganisms and antimicrobial susceptibility testing. The antimicrobial susceptibility of anaerobic microorganisms was tested with the gradient gradient test method. Results: It was determined that the most common 65 agent in DFI was Gram-negative aerobic bacteria and the majority of them 65 were multidrug resistant. The most common cause of monomicrobial infection is Staphylococcus aureus and the MRSA rate was found to be 27. The results of the study showed that vancomycin, teicoplanin and linezolid were the most effective antibiotics against Gram-positive agents. The most effective antibiotics against gram-negative agents were found to be ceftolozanetazobactam, piperacillintazobactam, meropenem, ertapenem, colistin and amikacin. Conclusions: Considering that the majority of Gram-negative agents consist of multidrug resistant microorganisms, the importance of prudent antibiotic use is once again increasing. It should be taken into account that diabetes is a disease that is 80 preventable with lifestyle changes, and the importance of increasing public awareness about healthy living should be emphasized.

 ÖZET Amaç: Diyabetik ayak DA, ülserasyon, enfeksiyon ve gangren gibi diyabete bağlı bir dizi alt ekstremite komplikasyonlarını tanımlayan klinik terimdir. Bu çalışmadaki amaç diyabetik ayak enfeksiyonu DAEnda etken aerob, anaerop bakteriler ve mantarların prospektif olarak araştırılmasıdır. Aynı zamanda kültürlerden elde edilen etken mikroorganizmaların antimikrobiyal duyarlılıkları araştırılacaktır. Gereç ve Yöntemler: Tip 2 Diabetes Mellitusu olan 50 hastadan alınan 59 örnek çalışmaya dahil edilmiştir. Mikroorganizmaların tür düzeyinde tanımlanması ve antimikrobiyal duyarlılık testleri için BD Phoenix TM otomatize sistem kullanılmıştır. Anaerob mikroorganizmaların antimikrobiyal duyarlılığı gradyan E- test yöntemiyle test edilmiştir. Bulgular: Çalışma sonucuna göre DAEde en sık 65 etken Gram-negatif aerob bakteriler olup, bunların büyük çoğunluğu 65 çoklu ilaca dirençli olarak saptanmıştır. Monomikrobiyal enfeksiyon nedeni olarak en sık S. aureus izole edilmiş ve MRSA oranı  27 olarak bulunmuştur. Çalışmanın sonuçları Gram-pozitif etkenlere vankomisin, teikoplanin ve linezolidin en etkili antibiyotikler olduğunu göstermiştir. Gram-negatif etkenlere karşı en etkili antibiyotikler ise seftolozantazobaktam, piperasilintazobaktam, meropenem, ertapenem, kolistin ve amikasin olarak bulunmuştur. Sonuç: Gram-negatif etkenlerin büyük çoğunluğunun çok ilaca dirençli olduğu dikkate alındığında akılcı antibiyotik kullanımının önemi bir kez daha ortaya çıkmaktadır. Diyabetin yaşam tarzı değişikliklerine bağlı 80 önlenebilir bir hastalık olduğu dikkate alınmalı ve sağlıklı hayat tarzı konusunda toplumsal bilinçlendirmenin önemi vurgulanmalıdır.

Makale detayları

Investigation Of Causing Microorganisms And Antimicrobial Sensitivity Patterns In Diabetic Foot Wounds

Yazarlar:

Aynur Ismayıl | Bayram Çolak | Serdar Yormaz | Hatice Türk Dağı | Salih Maçin

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.35 Issue 2, pp.276-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345141

pISSN:

2602-3741

Diabetic foot

diabetic foot ulcer

antibiotic susceptibility

microorganism

Sayı

Makale detayları

Investigation Of Causing Microorganisms And Antimicrobial Sensitivity Patterns In Diabetic Foot Wounds

Yazarlar: Aynur Ismayıl | Bayram Çolak | Serdar Yormaz | Hatice Türk Dağı | Salih Maçin

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Mikrobiyoloji

Dergi: Genel Tıp Dergisi Vol.35 Issue 2, pp.276-284

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345141

pISSN: 2602-3741

Diabetic foot

diabetic foot ulcer

antibiotic susceptibility

microorganism

Sayı

Yazarlar:

Aynur Ismayıl | Bayram Çolak | Serdar Yormaz | Hatice Türk Dağı | Salih Maçin

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Genel Tıp Dergisi Vol.35 Issue 2, pp.276-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345141

pISSN:

2602-3741