The Importance of Serum Procalcitonin and C-reactive Protein Levels in Patients with Lymphoma

Suat Sincan; Gülden Sincan; Zekeriya Aksöz; Fuat Erdem

Makale detayları

The Importance of Serum Procalcitonin and C-reactive Protein Levels in Patients with Lymphoma

Yazarlar:

Suat Sincan | Gülden Sincan | Zekeriya Aksöz | Fuat Erdem

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 2, pp.168-174

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348391

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Objective: Increased inflammatory cells in the tumor microenvironment are important in the formation and progression of lymphomas. C-reactive protein CRP and procalcitonin PCT are biomarkers that can be used to detect infection and inflammation. We investigated the clinical significance of CRP and PCT levels in lymphoma cases. Materials and Methods: We evaluated 82 Hodgkin and 120 diffuse large B-cell lymphoma DLBCL cases. Pre- and post-treatment PCT and CRP values were compared. The relationship between pre-treatment CRP and PCT levels and response to chemotherapy treatment, disease stage, performance score, extranodal involvement, presence of bulky mass, and bone marrow involvement was determined. Results: In the Hodgkin lymphoma group, the CRP level was increased in 40 48.8 patients and the PCT level was increased in 16 19.5 patients. The CRP level was high in 36 30 cases and the PCT level was high in 34 18.3 cases in the DLBCL group. CRP and PCT levels were significantly lower after chemotherapy treatment in all of our cases compared to pretreatment p0.001, p0.001, respectively. Conclusion: The decrease in CRP and PCT levels after chemotherapy treatment in our Hodgkin and DLBCL cases compared with pretreatment supports the role of inflammation in the pathogenesis. In addition, these parameters may contribute to the determination of prognosis.

 Objective: Increased inflammatory cells in the tumor microenvironment are important in the formation and progression of lymphomas. C-reactive protein CRP and procalcitonin PCT are biomarkers that can be used to detect infection and inflammation. We investigated the clinical significance of CRP and PCT levels in lymphoma cases. Materials and Methods: We evaluated 82 Hodgkin and 120 diffuse large B-cell lymphoma DLBCL cases. Pre- and post-treatment PCT and CRP values were compared. The relationship between pre-treatment CRP and PCT levels and response to chemotherapy treatment, disease stage, performance score, extranodal involvement, presence of bulky mass, and bone marrow involvement was determined. Results: In the Hodgkin lymphoma group, the CRP level was increased in 40 48.8 patients and the PCT level was increased in 16 19.5 patients. The CRP level was high in 36 30 cases and the PCT level was high in 34 18.3 cases in the DLBCL group. CRP and PCT levels were significantly lower after chemotherapy treatment in all of our cases compared to pretreatment p0.001, p0.001, respectively. Conclusion: The decrease in CRP and PCT levels after chemotherapy treatment in our Hodgkin and DLBCL cases compared with pretreatment supports the role of inflammation in the pathogenesis. In addition, these parameters may contribute to the determination of prognosis.

 Objective: Increased inflammatory cells in the tumor microenvironment are important in the formation and progression of lymphomas. C-reactive protein CRP and procalcitonin PCT are biomarkers that can be used to detect infection and inflammation. We investigated the clinical significance of CRP and PCT levels in lymphoma cases. Materials and Methods: We evaluated 82 Hodgkin and 120 diffuse large B-cell lymphoma DLBCL cases. Pre- and post-treatment PCT and CRP values were compared. The relationship between pre-treatment CRP and PCT levels and response to chemotherapy treatment, disease stage, performance score, extranodal involvement, presence of bulky mass, and bone marrow involvement was determined. Results: In the Hodgkin lymphoma group, the CRP level was increased in 40 48.8 patients and the PCT level was increased in 16 19.5 patients. The CRP level was high in 36 30 cases and the PCT level was high in 34 18.3 cases in the DLBCL group. CRP and PCT levels were significantly lower after chemotherapy treatment in all of our cases compared to pretreatment p0.001, p0.001, respectively. Conclusion: The decrease in CRP and PCT levels after chemotherapy treatment in our Hodgkin and DLBCL cases compared with pretreatment supports the role of inflammation in the pathogenesis. In addition, these parameters may contribute to the determination of prognosis.

 Objective: Increased inflammatory cells in the tumor microenvironment are important in the formation and progression of lymphomas. C-reactive protein CRP and procalcitonin PCT are biomarkers that can be used to detect infection and inflammation. We investigated the clinical significance of CRP and PCT levels in lymphoma cases. Materials and Methods: We evaluated 82 Hodgkin and 120 diffuse large B-cell lymphoma DLBCL cases. Pre- and post-treatment PCT and CRP values were compared. The relationship between pre-treatment CRP and PCT levels and response to chemotherapy treatment, disease stage, performance score, extranodal involvement, presence of bulky mass, and bone marrow involvement was determined. Results: In the Hodgkin lymphoma group, the CRP level was increased in 40 48.8 patients and the PCT level was increased in 16 19.5 patients. The CRP level was high in 36 30 cases and the PCT level was high in 34 18.3 cases in the DLBCL group. CRP and PCT levels were significantly lower after chemotherapy treatment in all of our cases compared to pretreatment p0.001, p0.001, respectively. Conclusion: The decrease in CRP and PCT levels after chemotherapy treatment in our Hodgkin and DLBCL cases compared with pretreatment supports the role of inflammation in the pathogenesis. In addition, these parameters may contribute to the determination of prognosis.

Makale detayları

The Importance of Serum Procalcitonin and C-reactive Protein Levels in Patients with Lymphoma

Yazarlar: Suat Sincan | Gülden Sincan | Zekeriya Aksöz | Fuat Erdem

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Meandros Medical And Dental Journal Vol.24 Issue 2, pp.168-174

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001348391

pISSN: 2149-9063

Procalcitonin

C-reactive protein

Hodgkin lymphoma

diffuse large B-cell lymphoma

prognosis

Sayı

Yazarlar:

Suat Sincan | Gülden Sincan | Zekeriya Aksöz | Fuat Erdem

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 2, pp.168-174

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348391

pISSN:

2149-9063