Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis

Fatma Göç; Aynur Sarı; Bekir Özer; Serdar Makbul; Kamil Coşkunçelebi

Makale detayları

Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis

Yazarlar:

Fatma Göç | Aynur Sarı | Bekir Özer | Serdar Makbul | Kamil Coşkunçelebi

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacognosy

Dergi:

İstanbul Journal of Pharmacy Vol.54 Issue 1, pp.61-68

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001318877

pISSN:

2587-2087

Anahtar kelimeler:

Özet:

 Background and Aims: Scorzonera ketzkhowelii Sosn. ex Grossh. Asteraceae was reported as a new species in the Flora of Turkey in 2010. However, there have been no prior biological or chemical investigations conducted. Methods: This study aims to investigate the antimicrobial activities of the petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions derived from S. ketzkhowelii, and determination of secondary metabolites by Liquid Chromatography with High Resolution Mass Spectrometry LC-HRMS analysis on the most active antimicrobial fractions. Results: Notably, all of the fractions demonstrated antimicrobial activity against selected microorganisms, with the dichloromethane fraction of the aerial part exhibiting a higher inhibition of microbial growth compared to the other extracts. The findings of our study revealed the presence of several phenolic compounds in the dichloromethane fractions from both the aerial and subaerial parts, including 3,4-dihydroxybenzaldehyde, salicylic acid, dihydrocaffeic acid, caffeic acid, caffeic acid phenethyl ester, chlorogenic acid, quercetin, hyperoside, naringenin, apigenin, hispidulin, hispidulin 7-glucoside, chrycin, emodin, and carnosic acid. Furthermore, dichloromethane fraction of the aerial parts contained additional phenolic compounds such as homogentisic acid, verbascoside, -trans taxifolin, apigenin 7-glucoside, luteolin, orientin, and chrysoeriol. Conclusion: The plants demonstrated antimicrobial attributes and the diverse range of phenolic compounds it contains present it as a promising subject for continued research and potential applications within the realms of medicine and pharmaceuticals. Further exploration of its bioactivity and potential health benefits may reveal novel avenues for its practical utilization.

 Background and Aims: Scorzonera ketzkhowelii Sosn. ex Grossh. Asteraceae was reported as a new species in the Flora of Turkey in 2010. However, there have been no prior biological or chemical investigations conducted. Methods: This study aims to investigate the antimicrobial activities of the petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions derived from S. ketzkhowelii, and determination of secondary metabolites by Liquid Chromatography with High Resolution Mass Spectrometry LC-HRMS analysis on the most active antimicrobial fractions. Results: Notably, all of the fractions demonstrated antimicrobial activity against selected microorganisms, with the dichloromethane fraction of the aerial part exhibiting a higher inhibition of microbial growth compared to the other extracts. The findings of our study revealed the presence of several phenolic compounds in the dichloromethane fractions from both the aerial and subaerial parts, including 3,4-dihydroxybenzaldehyde, salicylic acid, dihydrocaffeic acid, caffeic acid, caffeic acid phenethyl ester, chlorogenic acid, quercetin, hyperoside, naringenin, apigenin, hispidulin, hispidulin 7-glucoside, chrycin, emodin, and carnosic acid. Furthermore, dichloromethane fraction of the aerial parts contained additional phenolic compounds such as homogentisic acid, verbascoside, -trans taxifolin, apigenin 7-glucoside, luteolin, orientin, and chrysoeriol. Conclusion: The plants demonstrated antimicrobial attributes and the diverse range of phenolic compounds it contains present it as a promising subject for continued research and potential applications within the realms of medicine and pharmaceuticals. Further exploration of its bioactivity and potential health benefits may reveal novel avenues for its practical utilization.

 Background and Aims: Scorzonera ketzkhowelii Sosn. ex Grossh. Asteraceae was reported as a new species in the Flora of Turkey in 2010. However, there have been no prior biological or chemical investigations conducted. Methods: This study aims to investigate the antimicrobial activities of the petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions derived from S. ketzkhowelii, and determination of secondary metabolites by Liquid Chromatography with High Resolution Mass Spectrometry LC-HRMS analysis on the most active antimicrobial fractions. Results: Notably, all of the fractions demonstrated antimicrobial activity against selected microorganisms, with the dichloromethane fraction of the aerial part exhibiting a higher inhibition of microbial growth compared to the other extracts. The findings of our study revealed the presence of several phenolic compounds in the dichloromethane fractions from both the aerial and subaerial parts, including 3,4-dihydroxybenzaldehyde, salicylic acid, dihydrocaffeic acid, caffeic acid, caffeic acid phenethyl ester, chlorogenic acid, quercetin, hyperoside, naringenin, apigenin, hispidulin, hispidulin 7-glucoside, chrycin, emodin, and carnosic acid. Furthermore, dichloromethane fraction of the aerial parts contained additional phenolic compounds such as homogentisic acid, verbascoside, -trans taxifolin, apigenin 7-glucoside, luteolin, orientin, and chrysoeriol. Conclusion: The plants demonstrated antimicrobial attributes and the diverse range of phenolic compounds it contains present it as a promising subject for continued research and potential applications within the realms of medicine and pharmaceuticals. Further exploration of its bioactivity and potential health benefits may reveal novel avenues for its practical utilization.

 Background and Aims: Scorzonera ketzkhowelii Sosn. ex Grossh. Asteraceae was reported as a new species in the Flora of Turkey in 2010. However, there have been no prior biological or chemical investigations conducted. Methods: This study aims to investigate the antimicrobial activities of the petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions derived from S. ketzkhowelii, and determination of secondary metabolites by Liquid Chromatography with High Resolution Mass Spectrometry LC-HRMS analysis on the most active antimicrobial fractions. Results: Notably, all of the fractions demonstrated antimicrobial activity against selected microorganisms, with the dichloromethane fraction of the aerial part exhibiting a higher inhibition of microbial growth compared to the other extracts. The findings of our study revealed the presence of several phenolic compounds in the dichloromethane fractions from both the aerial and subaerial parts, including 3,4-dihydroxybenzaldehyde, salicylic acid, dihydrocaffeic acid, caffeic acid, caffeic acid phenethyl ester, chlorogenic acid, quercetin, hyperoside, naringenin, apigenin, hispidulin, hispidulin 7-glucoside, chrycin, emodin, and carnosic acid. Furthermore, dichloromethane fraction of the aerial parts contained additional phenolic compounds such as homogentisic acid, verbascoside, -trans taxifolin, apigenin 7-glucoside, luteolin, orientin, and chrysoeriol. Conclusion: The plants demonstrated antimicrobial attributes and the diverse range of phenolic compounds it contains present it as a promising subject for continued research and potential applications within the realms of medicine and pharmaceuticals. Further exploration of its bioactivity and potential health benefits may reveal novel avenues for its practical utilization.

Makale detayları

Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis

Yazarlar: Fatma Göç | Aynur Sarı | Bekir Özer | Serdar Makbul | Kamil Coşkunçelebi

Yayıncı: Istanbul University

Ana Başlıklar: Pharmacognosy

Dergi: İstanbul Journal of Pharmacy Vol.54 Issue 1, pp.61-68

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001318877

pISSN: 2587-2087

Scorzonera ketzkhowelii

Asteraceae

antimicrobial activity

LC-HRMS

phenolic compounds

Sayı

Yazarlar:

Fatma Göç | Aynur Sarı | Bekir Özer | Serdar Makbul | Kamil Coşkunçelebi

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacognosy

Dergi:

İstanbul Journal of Pharmacy Vol.54 Issue 1, pp.61-68

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001318877

pISSN:

2587-2087