Synthesis of Different Substituted Isocoumarin Derivatives Using Zinc Triflate Catalyst

Nesimi Uludağ

Makale detayları

Synthesis of Different Substituted Isocoumarin Derivatives Using Zinc Triflate Catalyst

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Mühendislik

Dergi:

Black Sea Journal of Engineering and Science Vol.6 Issue 2, pp.127-131

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001283945

pISSN:

2619-8991

Anahtar kelimeler:

Özet:

 Coumarins, which constitute a large class of natural compounds, are organic compounds that have attracted interest since the 19th century and have numerous practical applications. Coumarin compounds are heterocyclic compounds found in industry and in the structure of many commercial drugs. In this study, zinc-triflate-catalyzed tandem reactions of methyl 2-phenylethyl benzoate with but-3-en-2-one were applied for the synthesis of isocoumarins by a different method. The reaction was carried out under oxygen-free conditions using a convenient and environmentally benign reaction method in high yields and synthesized the targeted isoquamarine derivatives in a single step with the help of a novel catalyst. In addition, the effect of electron-withdrawing-electron-donating side groups on the formation and percentage yield of the reaction was investigated in this study. In summary, in this study, cascada reaction with palladium II-catalyzed highly regioselective but-3-en-2-one was developed.

 Coumarins, which constitute a large class of natural compounds, are organic compounds that have attracted interest since the 19th century and have numerous practical applications. Coumarin compounds are heterocyclic compounds found in industry and in the structure of many commercial drugs. In this study, zinc-triflate-catalyzed tandem reactions of methyl 2-phenylethyl benzoate with but-3-en-2-one were applied for the synthesis of isocoumarins by a different method. The reaction was carried out under oxygen-free conditions using a convenient and environmentally benign reaction method in high yields and synthesized the targeted isoquamarine derivatives in a single step with the help of a novel catalyst. In addition, the effect of electron-withdrawing-electron-donating side groups on the formation and percentage yield of the reaction was investigated in this study. In summary, in this study, cascada reaction with palladium II-catalyzed highly regioselective but-3-en-2-one was developed.

 Coumarins, which constitute a large class of natural compounds, are organic compounds that have attracted interest since the 19th century and have numerous practical applications. Coumarin compounds are heterocyclic compounds found in industry and in the structure of many commercial drugs. In this study, zinc-triflate-catalyzed tandem reactions of methyl 2-phenylethyl benzoate with but-3-en-2-one were applied for the synthesis of isocoumarins by a different method. The reaction was carried out under oxygen-free conditions using a convenient and environmentally benign reaction method in high yields and synthesized the targeted isoquamarine derivatives in a single step with the help of a novel catalyst. In addition, the effect of electron-withdrawing-electron-donating side groups on the formation and percentage yield of the reaction was investigated in this study. In summary, in this study, cascada reaction with palladium II-catalyzed highly regioselective but-3-en-2-one was developed.

 Geniş bir doğal bileşik sınıfı oluşturan kumarinler, 19. yüzyıldan günümüze değin oldukça ilgi çeken ve çok sayıda pratik uygulamaya sahip olan organik bileşiklerdir. Kumarin bileşikleri, endüstride ve birçok ticari ilacın yapısında bulunan heterosiklik bileşikler olup, bu çalışmada izokumarinlerin sentezleri için farklı bir yöntem izlenerek metil 2-feniletil benzoat 1a-g ve but-3-en-2-one 2nin çinko-triflat-katalizli tandem reaksiyonları gerçekleştirilmiştir. Söz konusu yöntemde, yüksek verimli ve çevre dostu bir reaksiyon oksijensiz ortamda gerçekleştirilmiş ve yeni bir katalizör kullanılarak hedeflenen izokumarin türevleri tek basamakta sentezlenmiştir. Diğer taraftan, elektron çekici ve elektron verici yan grupların reaksiyon oluşumuna ve verimine olan etkileri de araştırılmıştır. Özet olarak bu çalışmada, paladyumII-katalizli yüksek oranda regioselektif but-3-en-2-one ile cascada reaksiyonu ile geliştirilmiştir.

Makale detayları

Synthesis of Different Substituted Isocoumarin Derivatives Using Zinc Triflate Catalyst

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Mühendislik

Dergi:

Black Sea Journal of Engineering and Science Vol.6 Issue 2, pp.127-131

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001283945

pISSN:

2619-8991

Isocoumarin

Antimicrobial

Lactone

Inhibitor

Biological property

Cascada

İzokumarin

Antimikrobiyal

Lakton

İnhibitör

Biyolojik özellik

Cascada

Sayı

Makale detayları

Yazarlar: Nesimi Uludağ

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: Mühendislik

Dergi: Black Sea Journal of Engineering and Science Vol.6 Issue 2, pp.127-131

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001283945

pISSN: 2619-8991

Sayı

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Mühendislik

Dergi:

Black Sea Journal of Engineering and Science Vol.6 Issue 2, pp.127-131

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001283945

pISSN:

2619-8991