Evaluation of escitalopram induced reproductive toxicity in male Swiss albino mice

N.A.

Makale detayları

Evaluation of escitalopram induced reproductive toxicity in male Swiss albino mice

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.364-374

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345965

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Depression and anxiety are recognized as public health problems. For the treatment of major depressive disorder, antidepressant drugs are frequently prescribed worldwide. Antidepressants are a class of drugs that reduce the symptoms of depressive disorders by blocking the reuptake of neurotransmitter and by correcting chemical imbalances of neurotransmitters in the brain. The present study was carried out to evaluate the effects caused by escitalopram oxalate an SSRI antidepressant on male reproductive parameters of mice. The antidepressant drug was administered to Swiss albino male mice orally at the dose level of 10 mgkg b.w.d and 20 mgkg b.w.d for duration of 30 and 60 days. Body weight, relative sex organ weight, sperm parameters, biochemical parameters and marker of steroidogenesis were used as parameters to evaluate the toxicity of escitalopram oxalate on treated mice. The results showed significant decrease in body weight, weight of testis and epididymis. Escitalopram oxalate treatment also brought about marked reduction in sperm count, sperm motility and viability in exposed males. Testicular protein and sialic acid content reduced significantly whereas a significant increase in the glycogen and cholesterol content of testis was observed. In addition, 3 β-HSD and 17 β-HSD activity decreased significantly. In conclusion, escitalopram oxalate exerts toxic effects on testis of mice after 60 days of treatment at dose of 20mgkg b.w.d.

 Depression and anxiety are recognized as public health problems. For the treatment of major depressive disorder, antidepressant drugs are frequently prescribed worldwide. Antidepressants are a class of drugs that reduce the symptoms of depressive disorders by blocking the reuptake of neurotransmitter and by correcting chemical imbalances of neurotransmitters in the brain. The present study was carried out to evaluate the effects caused by escitalopram oxalate an SSRI antidepressant on male reproductive parameters of mice. The antidepressant drug was administered to Swiss albino male mice orally at the dose level of 10 mgkg b.w.d and 20 mgkg b.w.d for duration of 30 and 60 days. Body weight, relative sex organ weight, sperm parameters, biochemical parameters and marker of steroidogenesis were used as parameters to evaluate the toxicity of escitalopram oxalate on treated mice. The results showed significant decrease in body weight, weight of testis and epididymis. Escitalopram oxalate treatment also brought about marked reduction in sperm count, sperm motility and viability in exposed males. Testicular protein and sialic acid content reduced significantly whereas a significant increase in the glycogen and cholesterol content of testis was observed. In addition, 3 β-HSD and 17 β-HSD activity decreased significantly. In conclusion, escitalopram oxalate exerts toxic effects on testis of mice after 60 days of treatment at dose of 20mgkg b.w.d.

 Depression and anxiety are recognized as public health problems. For the treatment of major depressive disorder, antidepressant drugs are frequently prescribed worldwide. Antidepressants are a class of drugs that reduce the symptoms of depressive disorders by blocking the reuptake of neurotransmitter and by correcting chemical imbalances of neurotransmitters in the brain. The present study was carried out to evaluate the effects caused by escitalopram oxalate an SSRI antidepressant on male reproductive parameters of mice. The antidepressant drug was administered to Swiss albino male mice orally at the dose level of 10 mgkg b.w.d and 20 mgkg b.w.d for duration of 30 and 60 days. Body weight, relative sex organ weight, sperm parameters, biochemical parameters and marker of steroidogenesis were used as parameters to evaluate the toxicity of escitalopram oxalate on treated mice. The results showed significant decrease in body weight, weight of testis and epididymis. Escitalopram oxalate treatment also brought about marked reduction in sperm count, sperm motility and viability in exposed males. Testicular protein and sialic acid content reduced significantly whereas a significant increase in the glycogen and cholesterol content of testis was observed. In addition, 3 β-HSD and 17 β-HSD activity decreased significantly. In conclusion, escitalopram oxalate exerts toxic effects on testis of mice after 60 days of treatment at dose of 20mgkg b.w.d.

 Depression and anxiety are recognized as public health problems. For the treatment of major depressive disorder, antidepressant drugs are frequently prescribed worldwide. Antidepressants are a class of drugs that reduce the symptoms of depressive disorders by blocking the reuptake of neurotransmitter and by correcting chemical imbalances of neurotransmitters in the brain. The present study was carried out to evaluate the effects caused by escitalopram oxalate an SSRI antidepressant on male reproductive parameters of mice. The antidepressant drug was administered to Swiss albino male mice orally at the dose level of 10 mgkg b.w.d and 20 mgkg b.w.d for duration of 30 and 60 days. Body weight, relative sex organ weight, sperm parameters, biochemical parameters and marker of steroidogenesis were used as parameters to evaluate the toxicity of escitalopram oxalate on treated mice. The results showed significant decrease in body weight, weight of testis and epididymis. Escitalopram oxalate treatment also brought about marked reduction in sperm count, sperm motility and viability in exposed males. Testicular protein and sialic acid content reduced significantly whereas a significant increase in the glycogen and cholesterol content of testis was observed. In addition, 3 β-HSD and 17 β-HSD activity decreased significantly. In conclusion, escitalopram oxalate exerts toxic effects on testis of mice after 60 days of treatment at dose of 20mgkg b.w.d.

Makale detayları

Evaluation of escitalopram induced reproductive toxicity in male Swiss albino mice

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 1, pp.364-374

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345965

pISSN: 2630-6344

Escitalopram oxalate

reproductive toxicity

biochemical parameter

male Swiss albino mice

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.364-374

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345965

pISSN:

2630-6344