The Healing Effect of Resveratrol on Ischemic Tissue Injury in an Experimental Carbon Monoxide Poisoning Model

Aynur SAHİN; Sinan PASLİ; Mustafa CİCEK; Suleyman Caner KARAHAN; Ahmet MENTESE; Esin YULUG; Yunus KARACA; Ozgur TATLİ

doi:https://doi.org/10.30621/jbachs.2020.1197

Makale detayları

The Healing Effect of Resveratrol on Ischemic Tissue Injury in an Experimental Carbon Monoxide Poisoning Model

Yazarlar:

Aynur SAHİN | Sinan PASLİ | Mustafa CİCEK | Suleyman Caner KARAHAN | Ahmet MENTESE | Esin YULUG | Yunus KARACA | Ozgur TATLİ

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.288-296

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493431

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.1197

Özet:

 

Purpose: To investigate the healing effect of resveratrol on ischemia, inflammation and oxidative injury in brain and heart tissue of rats in an  experimentally induced carbonmonoxide  CO  intoxication model.  Methods: Twenty-eight mature female Spraque Dawley rats were randomized into four groups of seven animals each. Groups I and II inhaled  room air for 60 minutes. Groups III and IV inhaled a high concentration of a 5000 ppm CO gas mixture at 4 L/min until loss of consciousness.  Blood CO levels were measured from 1 mL blood specimens collected from the tail vein. Groups I and III received 1 mL of normal saline while  groups II and IV received 25 mg/kg resveratrol intraperitoneally. At the end of 48 hour, the rats were sacrified and later blood, brain and heart  tissue samples were taken for histopathological and biochemical evaluation. Neuron damage scores, percentages of degenerate neurons and  apoptosis rates in the cortex and hypothalamus were calculated in brain tissues. Myocyte degeneration, vascular congestion and myocyte  apoptosis rates were calculated in heart tissues. Total antioxidant  TAS , total oxidant  TOS  and oxidative stress index  OSI  levels were also  calculated from the tissue samples.  Results: Histopathological evaluation revealed that resveratrol significantly reduced tissue damage in the brain when groups III and IV were  compared  p.

Makale detayları

The Healing Effect of Resveratrol on Ischemic Tissue Injury in an Experimental Carbon Monoxide Poisoning Model

Yazarlar: Aynur SAHİN | Sinan PASLİ | Mustafa CİCEK | Suleyman Caner KARAHAN | Ahmet MENTESE | Esin YULUG | Yunus KARACA | Ozgur TATLİ

Yayıncı: Dokuz Eylul University

Dergi: Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.288-296

Belge Tipi: Makale

Yayın Tarihi: 8/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000493431

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.30621/jbachs.2020.1197

Sayı

Yazarlar:

Aynur SAHİN | Sinan PASLİ | Mustafa CİCEK | Suleyman Caner KARAHAN | Ahmet MENTESE | Esin YULUG | Yunus KARACA | Ozgur TATLİ

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.288-296

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493431

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.1197