Evaluation of DNA versus collagen perception in scientific articles examining cancer and radiation therapy: implication for collagen based approaches

Şule Karaman; Özge Karaçay; Yavuz Dizdar

Makale detayları

Evaluation of DNA versus collagen perception in scientific articles examining cancer and radiation therapy: implication for collagen based approaches

Yazarlar:

Şule Karaman | Özge Karaçay | Yavuz Dizdar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Sciences | Oncology and Carcinogenesis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.22-28

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281602

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Although radiation therapy has been used for more than a hundred years, its definitive mechanism of action is not known. Many studies indicate that radiation induces free radicals which damage DNA. However, irradiation should also affect the collagen connective tissue matrix. This database analysis aims to determine the extent of DNA versus collagen perception in scientific papers. Methods: Journals indexed in PubMed were searched on March 3, 2022, using the medical keywords cancer, radiation therapy, radiation therapy AND damage, radiation therapy AND mechanism AND damage, radiation therapy AND clinical. The number of items found for each search was proportioned in terms of DNA versus collagen and the ratio was accepted as the perception shift coefficient. Results: Results were tested with the p -value analysis to calculate the difference between the two proportions in both search items. Based on the main rule under the assumption that all cells have DNA and all cells live in the collagen matrix. In the p 1- p 2 analysis of the data, a significant  p  0.001 difference was obtained for all dichotomy scans. Conclusions: This data analysis supports the argument that both cancer and radiation therapy perception is DNA-based rather than collagen, since the synthesis and degradation process of very slow; it is not possible to observe it in short-term studies. The effects of irradiation should be further analyzed in this manner for purpose of collagen matrix interaction.

 Objectives: Although radiation therapy has been used for more than a hundred years, its definitive mechanism of action is not known. Many studies indicate that radiation induces free radicals which damage DNA. However, irradiation should also affect the collagen connective tissue matrix. This database analysis aims to determine the extent of DNA versus collagen perception in scientific papers. Methods: Journals indexed in PubMed were searched on March 3, 2022, using the medical keywords cancer, radiation therapy, radiation therapy AND damage, radiation therapy AND mechanism AND damage, radiation therapy AND clinical. The number of items found for each search was proportioned in terms of DNA versus collagen and the ratio was accepted as the perception shift coefficient. Results: Results were tested with the p -value analysis to calculate the difference between the two proportions in both search items. Based on the main rule under the assumption that all cells have DNA and all cells live in the collagen matrix. In the p 1- p 2 analysis of the data, a significant  p  0.001 difference was obtained for all dichotomy scans. Conclusions: This data analysis supports the argument that both cancer and radiation therapy perception is DNA-based rather than collagen, since the synthesis and degradation process of very slow; it is not possible to observe it in short-term studies. The effects of irradiation should be further analyzed in this manner for purpose of collagen matrix interaction.

 Objectives: Although radiation therapy has been used for more than a hundred years, its definitive mechanism of action is not known. Many studies indicate that radiation induces free radicals which damage DNA. However, irradiation should also affect the collagen connective tissue matrix. This database analysis aims to determine the extent of DNA versus collagen perception in scientific papers. Methods: Journals indexed in PubMed were searched on March 3, 2022, using the medical keywords cancer, radiation therapy, radiation therapy AND damage, radiation therapy AND mechanism AND damage, radiation therapy AND clinical. The number of items found for each search was proportioned in terms of DNA versus collagen and the ratio was accepted as the perception shift coefficient. Results: Results were tested with the p -value analysis to calculate the difference between the two proportions in both search items. Based on the main rule under the assumption that all cells have DNA and all cells live in the collagen matrix. In the p 1- p 2 analysis of the data, a significant  p  0.001 difference was obtained for all dichotomy scans. Conclusions: This data analysis supports the argument that both cancer and radiation therapy perception is DNA-based rather than collagen, since the synthesis and degradation process of very slow; it is not possible to observe it in short-term studies. The effects of irradiation should be further analyzed in this manner for purpose of collagen matrix interaction.

 Objectives: Although radiation therapy has been used for more than a hundred years, its definitive mechanism of action is not known. Many studies indicate that radiation induces free radicals which damage DNA. However, irradiation should also affect the collagen connective tissue matrix. This database analysis aims to determine the extent of DNA versus collagen perception in scientific papers. Methods: Journals indexed in PubMed were searched on March 3, 2022, using the medical keywords cancer, radiation therapy, radiation therapy AND damage, radiation therapy AND mechanism AND damage, radiation therapy AND clinical. The number of items found for each search was proportioned in terms of DNA versus collagen and the ratio was accepted as the perception shift coefficient. Results: Results were tested with the p -value analysis to calculate the difference between the two proportions in both search items. Based on the main rule under the assumption that all cells have DNA and all cells live in the collagen matrix. In the p 1- p 2 analysis of the data, a significant  p  0.001 difference was obtained for all dichotomy scans. Conclusions: This data analysis supports the argument that both cancer and radiation therapy perception is DNA-based rather than collagen, since the synthesis and degradation process of very slow; it is not possible to observe it in short-term studies. The effects of irradiation should be further analyzed in this manner for purpose of collagen matrix interaction.

Makale detayları

Evaluation of DNA versus collagen perception in scientific articles examining cancer and radiation therapy: implication for collagen based approaches

Yazarlar:

Şule Karaman | Özge Karaçay | Yavuz Dizdar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Sciences | Oncology and Carcinogenesis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.22-28

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281602

pISSN:

2149-3189

Radiation therapy

DNA

collagen

fuzzification

Sayı

Makale detayları

Evaluation of DNA versus collagen perception in scientific articles examining cancer and radiation therapy: implication for collagen based approaches

Yazarlar: Şule Karaman | Özge Karaçay | Yavuz Dizdar

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Clinical Sciences | Oncology and Carcinogenesis

Dergi: The European Research Journal Vol.9 Issue 1, pp.22-28

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001281602

pISSN: 2149-3189

Radiation therapy

DNA

collagen

fuzzification

Sayı

Yazarlar:

Şule Karaman | Özge Karaçay | Yavuz Dizdar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Sciences | Oncology and Carcinogenesis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.22-28

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281602

pISSN:

2149-3189