The efficacy of benzydamine on cancer treatment-induced oral mucositis: A systematic review of randomised controlled trials

Dilek Gümüş; Zeynep Yılmaz; Fuzuli Tuğrul

Makale detayları

The efficacy of benzydamine on cancer treatment-induced oral mucositis: A systematic review of randomised controlled trials

Yazarlar:

Dilek Gümüş | Zeynep Yılmaz | Fuzuli Tuğrul

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Oncology

Dergi:

The European Research Journal Vol.11 Issue 4, pp.809-820

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350985

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Mucositis is a well-known complication of oncological therapies, severely affecting the quality of life of patients. Benzydamine appears to be a promising option for the treatment of this condition, particularly in the management of oral mucositis. We can learn more about the potential use of benzydamine for oral mucositis by examining the available published research and what we know from clinical trials that have used this agent. This systematic review aims to evaluate the efficacy of benzydamine for the prevention and treatment of oral mucositis induced by cancer therapy through Randomized Controlled Trials. Methods: A systematic literature review was performed across seven databases. After screening, this systematic review included nine articles that had been published between 2013 and 2023. The review was conducted in accordance with the Cochrane guidelines 2023. Bias risk is assessed using the Cochrane Collaboration Risk of Bias Assessment Tool. The studies differed in the number of participants, from 26 to 120, giving a total of 593 participants analyzed. The articles in the studies used Benzydamine, herbal formulation, sodium bicarbonate, povidone-iodine, and low-level laser. Results: Results showed that benzydamine was effective to varying extents. Several studies provided statistically important improvements while others showed no statistically important variations. Conclusions: This extensive literature review and clinical study offer insight into how benzydamine may work in the management of oral mucositis.

 Objectives: Mucositis is a well-known complication of oncological therapies, severely affecting the quality of life of patients. Benzydamine appears to be a promising option for the treatment of this condition, particularly in the management of oral mucositis. We can learn more about the potential use of benzydamine for oral mucositis by examining the available published research and what we know from clinical trials that have used this agent. This systematic review aims to evaluate the efficacy of benzydamine for the prevention and treatment of oral mucositis induced by cancer therapy through Randomized Controlled Trials. Methods: A systematic literature review was performed across seven databases. After screening, this systematic review included nine articles that had been published between 2013 and 2023. The review was conducted in accordance with the Cochrane guidelines 2023. Bias risk is assessed using the Cochrane Collaboration Risk of Bias Assessment Tool. The studies differed in the number of participants, from 26 to 120, giving a total of 593 participants analyzed. The articles in the studies used Benzydamine, herbal formulation, sodium bicarbonate, povidone-iodine, and low-level laser. Results: Results showed that benzydamine was effective to varying extents. Several studies provided statistically important improvements while others showed no statistically important variations. Conclusions: This extensive literature review and clinical study offer insight into how benzydamine may work in the management of oral mucositis.

 Objectives: Mucositis is a well-known complication of oncological therapies, severely affecting the quality of life of patients. Benzydamine appears to be a promising option for the treatment of this condition, particularly in the management of oral mucositis. We can learn more about the potential use of benzydamine for oral mucositis by examining the available published research and what we know from clinical trials that have used this agent. This systematic review aims to evaluate the efficacy of benzydamine for the prevention and treatment of oral mucositis induced by cancer therapy through Randomized Controlled Trials. Methods: A systematic literature review was performed across seven databases. After screening, this systematic review included nine articles that had been published between 2013 and 2023. The review was conducted in accordance with the Cochrane guidelines 2023. Bias risk is assessed using the Cochrane Collaboration Risk of Bias Assessment Tool. The studies differed in the number of participants, from 26 to 120, giving a total of 593 participants analyzed. The articles in the studies used Benzydamine, herbal formulation, sodium bicarbonate, povidone-iodine, and low-level laser. Results: Results showed that benzydamine was effective to varying extents. Several studies provided statistically important improvements while others showed no statistically important variations. Conclusions: This extensive literature review and clinical study offer insight into how benzydamine may work in the management of oral mucositis.

 Objectives: Mucositis is a well-known complication of oncological therapies, severely affecting the quality of life of patients. Benzydamine appears to be a promising option for the treatment of this condition, particularly in the management of oral mucositis. We can learn more about the potential use of benzydamine for oral mucositis by examining the available published research and what we know from clinical trials that have used this agent. This systematic review aims to evaluate the efficacy of benzydamine for the prevention and treatment of oral mucositis induced by cancer therapy through Randomized Controlled Trials. Methods: A systematic literature review was performed across seven databases. After screening, this systematic review included nine articles that had been published between 2013 and 2023. The review was conducted in accordance with the Cochrane guidelines 2023. Bias risk is assessed using the Cochrane Collaboration Risk of Bias Assessment Tool. The studies differed in the number of participants, from 26 to 120, giving a total of 593 participants analyzed. The articles in the studies used Benzydamine, herbal formulation, sodium bicarbonate, povidone-iodine, and low-level laser. Results: Results showed that benzydamine was effective to varying extents. Several studies provided statistically important improvements while others showed no statistically important variations. Conclusions: This extensive literature review and clinical study offer insight into how benzydamine may work in the management of oral mucositis.

Makale detayları

The efficacy of benzydamine on cancer treatment-induced oral mucositis: A systematic review of randomised controlled trials

Yazarlar:

Dilek Gümüş | Zeynep Yılmaz | Fuzuli Tuğrul

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Oncology

Dergi:

The European Research Journal Vol.11 Issue 4, pp.809-820

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350985

pISSN:

2149-3189

Chemotherapy

radiotherapy

oral mucositis

benzydamine

systematic review

Sayı

Makale detayları

The efficacy of benzydamine on cancer treatment-induced oral mucositis: A systematic review of randomised controlled trials

Yazarlar: Dilek Gümüş | Zeynep Yılmaz | Fuzuli Tuğrul

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Clinical Oncology

Dergi: The European Research Journal Vol.11 Issue 4, pp.809-820

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001350985

pISSN: 2149-3189

Chemotherapy

radiotherapy

oral mucositis

benzydamine

systematic review

Sayı

Yazarlar:

Dilek Gümüş | Zeynep Yılmaz | Fuzuli Tuğrul

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Clinical Oncology

Dergi:

The European Research Journal Vol.11 Issue 4, pp.809-820

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350985

pISSN:

2149-3189