BORAKS KULLANIMINA BAĞLI KAN-TESTİS BARİYERİNDE GÖRÜLEN DEĞİŞİKLİKLERİN HİSTOLOJİK DEĞERLENDİRİLMESİ

Murat TOSUN; Tuğçe ALADAĞ; Esra GÖKALP; Gökçen GÖKÇE

Makale detayları

BORAKS KULLANIMINA BAĞLI KAN-TESTİS BARİYERİNDE GÖRÜLEN DEĞİŞİKLİKLERİN HİSTOLOJİK DEĞERLENDİRİLMESİ

Yazarlar:

Murat TOSUN | Tuğçe ALADAĞ | Esra GÖKALP | Gökçen GÖKÇE

Yayıncı:

Afyonkarahisar Sağlık Bilimleri Üniversitesi

Dergi:

Kocatepe Medical Journal 2018 Vol.19 Issue 4, pp.139-144

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000532509

Sıklık:

Aylık

eISSN:

2149-7869

Özet:

 


OBJECTIVE: The long-term use of boron compounds

commonly used in daily life has some dose-dependent

toxic effects on different organs For this purpose, in our

study, we aimed to determine the change in blood-testis

barrier structure and the number of leydig cells in

the testis of rats in which were given borax at different

doses.


MATERIAL AND METHODS: In our study, 4 groups, in

each have 6 male rats were made. Different doses of

borax were given orally to rats in each groups. After

the experiment, the left testis was excised,

histologically processed and stained with Claudin-1,

Pan cadherin and Calretinin immunohistochemically

and evaluated under light microscopy.


RESULTS: In testis slides, it was determined that Cadherin

expression decreased parallel to borax doses. However,

it was observed that the expression of Claudin 1 did

not change much between the groups. The number of

Leydig cells was observed to decrease in rats administered

once with an LD50x2 dose.


CONCLUSIONS: The findings suggest that the use of

borax may be deleterious to the blood-testis barrier

components in the testes. These effects have the potential

to cause long term infertility problems. For this reason, we

consider that it is necessary to take important preventive

measures in terms of environmental pollution, especially

around boron components production centers.

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Makale detayları

BORAKS KULLANIMINA BAĞLI KAN-TESTİS BARİYERİNDE GÖRÜLEN DEĞİŞİKLİKLERİN HİSTOLOJİK DEĞERLENDİRİLMESİ

Yazarlar: Murat TOSUN | Tuğçe ALADAĞ | Esra GÖKALP | Gökçen GÖKÇE

Yayıncı: Afyonkarahisar Sağlık Bilimleri Üniversitesi

Dergi: Kocatepe Medical Journal 2018 Vol.19 Issue 4, pp.139-144

Belge Tipi: Makale

Yayın Tarihi: 10/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000532509

Sıklık: Aylık

eISSN: 2149-7869

Sayı

Yazarlar:

Murat TOSUN | Tuğçe ALADAĞ | Esra GÖKALP | Gökçen GÖKÇE

Yayıncı:

Afyonkarahisar Sağlık Bilimleri Üniversitesi

Dergi:

Kocatepe Medical Journal 2018 Vol.19 Issue 4, pp.139-144

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000532509

Sıklık:

Aylık

eISSN:

2149-7869