Pregabalin protected cisplatin-induced oxidative neurotoxicity in neuronal cell line

Kemal ERTİLAV

doi:https://doi.org/10.37212/jcnos.653500

Makale detayları

Pregabalin protected cisplatin-induced oxidative neurotoxicity in neuronal cell line

Yazarlar:

Kemal ERTİLAV

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.815-824

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000708809

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.653500

Özet:

 

Cisplatin (CSP) is used treatment of several cancers. However, it has also adverse effect through excessive reactive oxygen species production and activation of TRPV1 channel activation in neurons. Pregabalin (PGAB) has antioxidant and calcium channel blocker actions in neurons. I have investigated protective role of PGAB against the adverse effects of CSP in DBTRG neuronal cells. The neuronal cells were divided into four groups as control group, PGAB group (500 M for 24 1 hrs), CSP group (25 M for 24 hrs), and PGAB+CSP combination group. CISP-induced decrease of cell viability, glutathione peroxidase and glutathione level in the cells were increased in the neurons by PGAB treatment. However, CSP-induced increase of apoptosis, Ca2+ fluorescence intensity, TRPV1 current densities through the increase mitochondrial oxidative stress were decreased in the neurons by PGAB treatment. In conclusion, CSP-induced increases in mitochondrial ROS and cell death levels in the neuronal cells were decreased through the decrease of TRPV1 activation with the effect of PGAB treatment. CSP-induced drug resistance in the neurons might be reduced by PGAB treatment.

Makale detayları

Pregabalin protected cisplatin-induced oxidative neurotoxicity in neuronal cell line

Yazarlar: Kemal ERTİLAV

Yayıncı: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi: Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.815-824

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000708809

Sıklık: Üç Yıllık

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.653500

Sayı

Yazarlar:

Kemal ERTİLAV

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2019 Vol.11 Issue 1, pp.815-824

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000708809

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.653500