Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Leila SAREMI; Shirin LOTFIPANAH; Masumeh MOHAMMADI; Hassan HOSSEINZADEH; Zahra HOSSEINI-KHAH; Behrooz JOHARI; Zohreh SALTANATPOUR

Makale detayları

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Yazarlar:

Leila SAREMI | Shirin LOTFIPANAH | Masumeh MOHAMMADI | Hassan HOSSEINZADEH | Zahra HOSSEINI-KHAH | Behrooz JOHARI | Zohreh SALTANATPOUR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1089-1094

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749990

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  Environmental  and  genetic  factors  may  play  a  major  role  in  the  development  of  nonalcoholic  fatty  liver  disease  (NAFLD)  among  people  with  obesity  and  type  2  diabetes  mellitus.  Based  on  the  fact  that  PGC-1?,  as  the  protein  encoded  by  the  PPARGC1A gene, plays a key role in energy metabolism pathways, it has been hypothesized that polymorphisms within the PPARGC1Agene  may  be  associated  with  increased  risks  of  NAFLD.  Thus,  this  study  was  designed  to  evaluate  the  Gly482Ser  polymorphism  (rs8192678) within the PPARGC1A gene and its association with the increased risk of NAFLD in Iranian patients with type 2 diabetes.Materials and methods: A total of 145 NAFLD patients with a history of type 2 diabetes and 145 healthy control subjects were included in  the  study.  Gly482Ser  polymorphism  genotyping  was  done  using  the  amplification  refractory  mutation  system-polymerase  chain  reaction (ARMS-PCR) technique.Results: The  results  showed  a  significant  difference  between  the  PPARGC1A Gly482Serpolymorphism  in  NAFLD  patients  and  the  healthy  controls.  Accordingly,  the  AA  genotype  and  A  allele  were  increased  in  the  NAFLD  patients  when  compared  to  the  healthy  controls. However, no significant correlation was observed between the Gly482Ser polymorphism and the physiological and biochemical parameters.Conclusion: Based on the results, the AA genotype, which is associated with the insertion of Ser, can be considered as a risk factor for the development of NAFLD in Iranian patients with diabetes type 2.

Makale detayları

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Yazarlar: Leila SAREMI | Shirin LOTFIPANAH | Masumeh MOHAMMADI | Hassan HOSSEINZADEH | Zahra HOSSEINI-KHAH | Behrooz JOHARI | Zohreh SALTANATPOUR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1089-1094

Belge Tipi: Makale

Yayın Tarihi: 7/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749990

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Leila SAREMI | Shirin LOTFIPANAH | Masumeh MOHAMMADI | Hassan HOSSEINZADEH | Zahra HOSSEINI-KHAH | Behrooz JOHARI | Zohreh SALTANATPOUR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1089-1094

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749990

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144