Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis

Hakan SENTURK; Gokhan BAYRAMOGLU; Ali DOKUMACİOGLU; Erinc ARAL; Gungor KANBAK; Mine İNAL; Aysegul OGLAKCİ

Makale detayları

Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis

Yazarlar:

Hakan SENTURK | Gokhan BAYRAMOGLU | Ali DOKUMACİOGLU | Erinc ARAL | Gungor KANBAK | Mine İNAL | Aysegul OGLAKCİ

Yayıncı:

Ersin YÜCEL

Dergi:

Biological Diversity and Conservation 2012 Vol.5 Issue 2, pp.59-65

Belge Tipi:

Makale

Yayın Tarihi:

8/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000893880

Sıklık:

Üç Yıllık

eISSN:

1308-8084

pISSN:

1308-5301

Özet:

 

In order to investigate putative protective effects of Echinacea purpurea on colonic inflammation, we determined Adenosine deaminase  ADA  and superoxide dismutase  SOD  activities, malondialdehyde  MDA  levels and protein carbonyl contents were determined in colonic tissues of rats in the colitis and colitis plus Echinacea purpurea  at different doses 50,100 mg/kg  given rats. Besides, histopathology of colon tissues were evaluated. In the Echinacea treatment groups  50 and 100 mg/kg doses  ADA activities were significantly decreased as compared to acetic acid group, but there was no statistically significant between two treatment groups  p>0.05 . Echinacea treatment also was decreased MDA levels at two doses according to colitis group  p0.05 . Slightly decreased protein carbonyl contents and elevated SOD activities were shown in the two Echinacea therapy groups as compared to acetic acid induced colitis group. But these were not statistically significant  p>0.05 . Similar observations were recorded for these parameters in the extracts of colonic tissue specimens. The results revealed that pretreatment to colitic rats with Echinacea purpurea at doses of 50 and 100 mg/kg, partially attenuated the colonic damage induced by acetic acid. In conclusion, the preventive effects of Echinacea purpurea in the acetic acid model of rat colitis is probably related to its antioxidant properties, due to its flavonoid content. Abbreviations: ADA=Adenosine deaminase, SOD= superoxide dismutase, MDA= malondialdehyde, IBD= Inflammatory bowel diseases, UC= ulcerative colitis, ROS= reactive oxygen species, NO= nitric oxide, US= United States, NBT= nitrobluetetrazolium, TBA= thiobarbituric acid, SPSS=Statistical Package for Social Sciences.

Makale detayları

Protective effects of Echinacea purpurea in an acetic acid induced rat model of colitis

Yazarlar: Hakan SENTURK | Gokhan BAYRAMOGLU | Ali DOKUMACİOGLU | Erinc ARAL | Gungor KANBAK | Mine İNAL | Aysegul OGLAKCİ

Yayıncı: Ersin YÜCEL

Dergi: Biological Diversity and Conservation 2012 Vol.5 Issue 2, pp.59-65

Belge Tipi: Makale

Yayın Tarihi: 8/2012

Belge Dili: İngilizce

Document ID (Org No.): 2000893880

Sıklık: Üç Yıllık

eISSN: 1308-8084

pISSN: 1308-5301

Sayı

Yazarlar:

Hakan SENTURK | Gokhan BAYRAMOGLU | Ali DOKUMACİOGLU | Erinc ARAL | Gungor KANBAK | Mine İNAL | Aysegul OGLAKCİ

Yayıncı:

Ersin YÜCEL

Dergi:

Biological Diversity and Conservation 2012 Vol.5 Issue 2, pp.59-65

Belge Tipi:

Makale

Yayın Tarihi:

8/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000893880

Sıklık:

Üç Yıllık

eISSN:

1308-8084

pISSN:

1308-5301