Investigation of the bactericidal effects of vancomycin and quinupristin/dalfopristin on Staphylococcus aureus isolates

Mine HOŞGÖR-LİMONCU; Şafak ERMERTCAN; Güner COŞAR

Makale detayları

Investigation of the bactericidal effects of vancomycin and quinupristin/dalfopristin on Staphylococcus aureus isolates

Yazarlar:

Mine HOŞGÖR-LİMONCU | Şafak ERMERTCAN | Güner COŞAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2004 Vol.34 Issue 2, pp.115-119

Belge Tipi:

Makale

Yayın Tarihi:

1/2004

Belge Dili:

Türkçe

Document ID (Org No.):

2000756621

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The present study aimed to determine the correlation between the bactericidal activity of vancomycin and quinupristin/dalfopristin (Q/D) on Staphylococcus aureus isolates and their minimal inhibition concentrations. The in-vitro susceptibilities of the 99 S. aureus isolates to vancomycin and Q/D were investigated by agar dilution. Thirty methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA) vancomycin and Q/D susceptible isolates were involved in time-kill studies. While both MRSA and MSSA isolates were susceptible to vancomycin, 96% of both isolates were determined as susceptible to Q/D. In the time-kill test, after 6 h of incubation vancomycin exhibited a bactericidal activity of 90% on MRSA and 100% on MSSA isolates. On the other hand, in the same incubation period Q/D was 47% and 93% bactericidal for MRSA and MSSA isolates, respectively. After 24 h of incubation, while vancomycin was bactericidal for all MRSA and MSSA isolates, Q/D exhibited a bactericidal activity of 93% on MRSA isolates and 97% on MSSA isolates.

 

The present study aimed to determine the correlation between the bactericidal activity of vancomycin and quinupristin/dalfopristin (Q/D) on Staphylococcus aureus isolates and their minimal inhibition concentrations. The in-vitro susceptibilities of the 99 S. aureus isolates to vancomycin and Q/D were investigated by agar dilution. Thirty methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA) vancomycin and Q/D susceptible isolates were involved in time-kill studies. While both MRSA and MSSA isolates were susceptible to vancomycin, 96% of both isolates were determined as susceptible to Q/D. In the time-kill test, after 6 h of incubation vancomycin exhibited a bactericidal activity of 90% on MRSA and 100% on MSSA isolates. On the other hand, in the same incubation period Q/D was 47% and 93% bactericidal for MRSA and MSSA isolates, respectively. After 24 h of incubation, while vancomycin was bactericidal for all MRSA and MSSA isolates, Q/D exhibited a bactericidal activity of 93% on MRSA isolates and 97% on MSSA isolates.

Makale detayları

Investigation of the bactericidal effects of vancomycin and quinupristin/dalfopristin on Staphylococcus aureus isolates

Yazarlar: Mine HOŞGÖR-LİMONCU | Şafak ERMERTCAN | Güner COŞAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2004 Vol.34 Issue 2, pp.115-119

Belge Tipi: Makale

Yayın Tarihi: 1/2004

Belge Dili: Türkçe

Document ID (Org No.): 2000756621

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Staphylococcus aureus

vancomycin

quinupristin/dalfopristin

bactericidal effect

Sayı

Yazarlar:

Mine HOŞGÖR-LİMONCU | Şafak ERMERTCAN | Güner COŞAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2004 Vol.34 Issue 2, pp.115-119

Belge Tipi:

Makale

Yayın Tarihi:

1/2004

Belge Dili:

Türkçe

Document ID (Org No.):

2000756621

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144