The Determination of IL-6 rs1800795 Polymorphism Distribution in Turkish  National Cross-Country Skiing Athletes Sub-groups Created Referring to the 1km CCSTAs

Derya KAZANCI; Tolga POLAT; Canan SERCAN DOĞAN; Beste TACAL ASLAN; Şehkar OKTAY; Muhammed Fatih BİLİCİ; Ömer KAYNAR; Başak Funda EKEN; Korkut ULUCAN

doi:https://doi.org/10.33808/clinexphealthsci.904524

Makale detayları

The Determination of IL-6 rs1800795 Polymorphism Distribution in Turkish National Cross-Country Skiing Athletes Sub-groups Created Referring to the 1km CCSTAs

Yazarlar:

Derya KAZANCI | Tolga POLAT | Canan SERCAN DOĞAN | Beste TACAL ASLAN | Şehkar OKTAY | Muhammed Fatih BİLİCİ | Ömer KAYNAR | Başak Funda EKEN | Korkut ULUCAN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2021 Vol.11 Issue 4, pp.782-786

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000906701

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.904524

Özet:

 

Objective: Interleukin-6 (IL-6) is an effective and functional protein with a cytokine structure. IL-6 is effective in the immune system like a pro/anti-inflammatory response, and muscle tissue hypertrophy and repair.  Our study aimed to investigate the IL-6 rs1800795 polymorphism distribution in Turkish National Cross-Country Skiing Athletes and to determine the advantageous genotype for endurance performance. 
Methods: 34 athletes within 3 groups; General (Group-1), Women (Group-2), and Men (Group-3) were enrolled to the study. Also each groups were divided into sub-groups according to their “1-kilometer cross-country average skiing-times (1 km-CCSTAs)”. Blood samples were used for DNA isolation and genotyping were completed by real time- PCR. 
Results: The groups' 1 km-CCSTAs were 188.7 ± 22.4, 212.3 ± 17.8, and 177.4 ± 14.1 seconds, respectively. We detected the genotypes as 17 GG (50%) and 17 GC (50%) in Group-1; 5 GG (45%) and 6 GC (55%) in Group-2; 12 GG (52%) and 11 GC (48%) in Group- 3. We detected no CC genotype in groups. Chi-square Fisher’s test was used for statistical analysis. 
Conclusion: An increased GC genotype ratio was detected in the faster sub-groups of each group compared to the slower sub-groups. But we obtained the significant genotype distribution only in Group-3 (p <0.0001). Also, an increased C-allele frequency was detected in the faster sub-groups. However, the significant allele gene distribution was obtained only in Group-3 (p=0.0002). According to our results, we can speculate that the GC genotype is more advantageous than the GG genotype in Cross-Country Skiing Athletes.

Makale detayları

The Determination of IL-6 rs1800795 Polymorphism Distribution in Turkish National Cross-Country Skiing Athletes Sub-groups Created Referring to the 1km CCSTAs

Yazarlar: Derya KAZANCI | Tolga POLAT | Canan SERCAN DOĞAN | Beste TACAL ASLAN | Şehkar OKTAY | Muhammed Fatih BİLİCİ | Ömer KAYNAR | Başak Funda EKEN | Korkut ULUCAN

Yayıncı: Marmara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Clinical and Experimental Health Sciences 2021 Vol.11 Issue 4, pp.782-786

Belge Tipi: Makale

Yayın Tarihi: 10/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000906701

Sıklık: Aylık

eISSN: 2459-1459

DOI: https://doi.org/10.33808/clinexphealthsci.904524

Sayı

Yazarlar:

Derya KAZANCI | Tolga POLAT | Canan SERCAN DOĞAN | Beste TACAL ASLAN | Şehkar OKTAY | Muhammed Fatih BİLİCİ | Ömer KAYNAR | Başak Funda EKEN | Korkut ULUCAN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2021 Vol.11 Issue 4, pp.782-786

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000906701

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.904524