Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Mustafa ERGÜL; Adamu BEKELE; Hatice TERZİ; Ahmet ALTUN

doi:https://doi.org/10.7197/cmj.vi.578764

Makale detayları

Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Yazarlar:

Mustafa ERGÜL | Adamu BEKELE | Hatice TERZİ | Ahmet ALTUN

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.500-505

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922482

DOI:

https://doi.org/10.7197/cmj.vi.578764

Özet:

 


Cancer
is the main cause of death and morbidity worldwide. Among females, breast
cancer is the most commonly diagnosed and the leading cause of cancer-related
death. Despite an improvement in the treatment of cancer in the latest years,
metastatic breast cancer treatment success is not at a desirable level. Plants
have huge potential to endow us with noble drugs and current drugs of plant
origin are important part of cancer chemotherapy. The aim of this study was to
evaluate the antiproliferative activity of wheat germ oil in MCF-7 breast cancer
cell line. Antiproliferative
activity and apoptotic effect of wheat germ oil were examined using the XTT
and flow cytometry assay, respectively. According to the XTT results, at concentrations
greater than 0.5 mg/mL, wheat germ oil displayed significant antiproliferative
activity in MCF-7 cells in a dose-dependent manner. The Annexin V binding assay
results also demonstrated that the IC50 concentration of wheat germ oil
increased early and late apoptotic populations (p < 0.05). Though further
studies are required to
specifically identify compounds involved in the anticancer activity of wheat
germ oil, our findings demonstrate that wheat germ oil inhibits proliferation
of MCF-7 cells and its action is dose-dependent.



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Makale detayları

Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Yazarlar: Mustafa ERGÜL | Adamu BEKELE | Hatice TERZİ | Ahmet ALTUN

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.500-505

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000922482

DOI: https://doi.org/10.7197/cmj.vi.578764

Sayı

Yazarlar:

Mustafa ERGÜL | Adamu BEKELE | Hatice TERZİ | Ahmet ALTUN

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 3, pp.500-505

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922482

DOI:

https://doi.org/10.7197/cmj.vi.578764