Association of SOD2 Polymorphism (Rs4880) and Competitive Performance in Track and Field Athletes

Hasan Huseyin Kazan; Celal Bulğay; Erdal Zorba; Işık Bayraktar; Mesut Cerit; Mehmet Ali Ergun

Makale detayları

Association of SOD2 Polymorphism (Rs4880) and Competitive Performance in Track and Field Athletes

Yazarlar:

Hasan Huseyin Kazan | Celal Bulğay | Erdal Zorba | Işık Bayraktar | Mesut Cerit | Mehmet Ali Ergun

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Spor Hekimliği

Dergi:

Spor ve Performans Araştırmaları Dergisi Vol.14 Issue 1, pp.59-68

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288206

pISSN:

1309-8543

Anahtar kelimeler:

Özet:

 The rs4880 polymorphism in the SOD2 gene has frequently been associated with the athletic performance of the athletes in different populations. However, there were not any studies in the Turkish elite athletes. Thus, the aim of the study is to evaluate the impacts of SOD2 rs4880 polymorphism on competitive performance of Turkish elite athletes. A total of 60 elite athletes 31 sprintpower and 29 endurance and 20 controls with the ages of 18-35 voluntarily participated in the study. World Athletics WA score table was used to determine the performance levels of the competitive performancepersonal best PB of the athletes. Whole exome sequencing WES was performed by the genomic DNA isolated from peripheral blood of the participants. Sport type, sex and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. There were not any significances between the genotype and allele frequencies. Finally, there were not any associations between competitive performance and genotype frequencies within the sprintpower athletes while competitive performance was significantly p0.049 correlated with rs4880 polymorphism according to the over-dominant model within the endurance athletes. The rs4880 polymorphism in the SOD2 gene may be linked to the competitive performance of the endurance athletes. Still, further studies with more participants and analyzing multiple factors are needed.

 The rs4880 polymorphism in the SOD2 gene has frequently been associated with the athletic performance of the athletes in different populations. However, there were not any studies in the Turkish elite athletes. Thus, the aim of the study is to evaluate the impacts of SOD2 rs4880 polymorphism on competitive performance of Turkish elite athletes. A total of 60 elite athletes 31 sprintpower and 29 endurance and 20 controls with the ages of 18-35 voluntarily participated in the study. World Athletics WA score table was used to determine the performance levels of the competitive performancepersonal best PB of the athletes. Whole exome sequencing WES was performed by the genomic DNA isolated from peripheral blood of the participants. Sport type, sex and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. There were not any significances between the genotype and allele frequencies. Finally, there were not any associations between competitive performance and genotype frequencies within the sprintpower athletes while competitive performance was significantly p0.049 correlated with rs4880 polymorphism according to the over-dominant model within the endurance athletes. The rs4880 polymorphism in the SOD2 gene may be linked to the competitive performance of the endurance athletes. Still, further studies with more participants and analyzing multiple factors are needed.

 The rs4880 polymorphism in the SOD2 gene has frequently been associated with the athletic performance of the athletes in different populations. However, there were not any studies in the Turkish elite athletes. Thus, the aim of the study is to evaluate the impacts of SOD2 rs4880 polymorphism on competitive performance of Turkish elite athletes. A total of 60 elite athletes 31 sprintpower and 29 endurance and 20 controls with the ages of 18-35 voluntarily participated in the study. World Athletics WA score table was used to determine the performance levels of the competitive performancepersonal best PB of the athletes. Whole exome sequencing WES was performed by the genomic DNA isolated from peripheral blood of the participants. Sport type, sex and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. There were not any significances between the genotype and allele frequencies. Finally, there were not any associations between competitive performance and genotype frequencies within the sprintpower athletes while competitive performance was significantly p0.049 correlated with rs4880 polymorphism according to the over-dominant model within the endurance athletes. The rs4880 polymorphism in the SOD2 gene may be linked to the competitive performance of the endurance athletes. Still, further studies with more participants and analyzing multiple factors are needed.

 SOD2 rs4880 polimorfizmi, farklı popülasyonlarda, atletlerin atletik performanslarıyla sıkça ilişkilendirilen varyantlardandır. Ancak, Türk elit atletlerde, bu varyantın atletik performans üzerine etkisine yönelik herhangi bir çalışma yoktur. Bu nedenle, sunulan çalışmanın amacı, elit atletlerde, SOD2 rs4880 polimorfizminin yarışma performansı üzerindeki olası etkilerini açığa çıkartmayı amaçlamaktadır. Çalışmaya 18-35 yaşları arasında 31 sprintgüç ve 29 dayanıklılık olmak üzere toplam 60 elit atlet ve 20 sedanter birey dahil edilmiştir. Atletlerin yarışma performanslarıbireysel en iyi dereceleri PB, Dünya Atletizm WA birliğinin performans puanlama sistemine göre belirlenmiştir. Katılımcıların kanlarından izole edilen genomik DNA ile tüm ekzom dizileme WES gerçekleştirilmiştir. Spor branşı, cinsiyet ve yarışma performansı, doğrusal regresyon modeli ile grup içi ve gruplar arası kıyaslanan parametreler olarak seçilmiştir. Grup içinde ve gruplar arasında, alel ve genotip frekansları arasında bir farklılık görülmemiştir. Sprintgüç grubu atletlerde, yarışma performansı ile genotip frekansı arasında anlamlı bir ilişki görülmezken dayanıklılık grubu atletlerde, rs4880 polimorfizminin yarışma performansı ile istatistiksel olarak anlamlı bir şekilde p0.049 ilişkili olduğu görülmüştür. Bu çalışma ile SOD2 rs4880 polimorfizminin dayanıklılık branşı ile ilişkili olabileceği söylenebilir. Yine de çok katılımlı bir grupla diğer genetik varyasyonların dahiliyle ileri çalışmalara ihtiyaç duyulmaktadır.

Makale detayları

Association of SOD2 Polymorphism (Rs4880) and Competitive Performance in Track and Field Athletes

Yazarlar:

Hasan Huseyin Kazan | Celal Bulğay | Erdal Zorba | Işık Bayraktar | Mesut Cerit | Mehmet Ali Ergun

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Spor Hekimliği

Dergi:

Spor ve Performans Araştırmaları Dergisi Vol.14 Issue 1, pp.59-68

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288206

pISSN:

1309-8543

Athlete

Athletic Performance

Athletics

rs4880 Polymorphism

SOD2Sporcular

Atletik Performans

Atletizm

rs4880 Polimorfizm

SOD2

Sayı

Makale detayları

Yazarlar: Hasan Huseyin Kazan | Celal Bulğay | Erdal Zorba | Işık Bayraktar | Mesut Cerit | Mehmet Ali Ergun

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Spor Hekimliği

Dergi: Spor ve Performans Araştırmaları Dergisi Vol.14 Issue 1, pp.59-68

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001288206

pISSN: 1309-8543

Sayı

Yazarlar:

Hasan Huseyin Kazan | Celal Bulğay | Erdal Zorba | Işık Bayraktar | Mesut Cerit | Mehmet Ali Ergun

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Spor Hekimliği

Dergi:

Spor ve Performans Araştırmaları Dergisi Vol.14 Issue 1, pp.59-68

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288206

pISSN:

1309-8543