Combinations of Interleukin-10 gene promoter polymorphisms with -1082A, -819T, -592A minor allele are associated with sinonasal polyposis

Sibel OZDAS

doi:https://doi.org/10.17350/HJSE19030000105

Makale detayları

Combinations of Interleukin-10 gene promoter polymorphisms with -1082A, -819T, -592A minor allele are associated with sinonasal polyposis

Yazarlar:

Sibel OZDAS

Yayıncı:

Hitit University

Dergi:

Hittite Journal of Science and Engineering 2018 Vol.5 Issue 4, pp.285-292

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000451638

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000105

Özet:

 

S inonasal polyposis  SP  is an inflammatory disease involving multiple etiologies and pathogenesis. The disarray of Interleukin  IL -10 is associated with a raised immunopathological response during the progression of many autoimmune diseases as well as the response to infection. We studied the possible role of the single nucleotide polymorphisms  SNPs  in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’s promoter was genotyped in 200 participants  100 patients and 100 controls . The sites that were encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzed by sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A, -819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsigniŞcantly higher risks for SP  P.

Makale detayları

Combinations of Interleukin-10 gene promoter polymorphisms with -1082A, -819T, -592A minor allele are associated with sinonasal polyposis

Yazarlar: Sibel OZDAS

Yayıncı: Hitit University

Dergi: Hittite Journal of Science and Engineering 2018 Vol.5 Issue 4, pp.285-292

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000451638

Sıklık: Üç Aylık

eISSN: 2148-4171

DOI: https://doi.org/10.17350/HJSE19030000105

Sayı

Yazarlar:

Sibel OZDAS

Yayıncı:

Hitit University

Dergi:

Hittite Journal of Science and Engineering 2018 Vol.5 Issue 4, pp.285-292

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000451638

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000105