Association of Hypophosphatemia with Morbidity and Mortality in Patients with COVID-19

Faruk Karandere; Deniz Yılmaz; Felemez Arslan; Ezgi Şahin; Sema Koyuncu

Makale detayları

Association of Hypophosphatemia with Morbidity and Mortality in Patients with COVID-19

Yazarlar:

Faruk Karandere | Deniz Yılmaz | Felemez Arslan | Ezgi Şahin | Sema Koyuncu

Yayıncı:

Alanya Alaaddin Keykubat Üniversitesi

Ana Başlıklar:

İç Hastalıkları

Dergi:

Acta Medica Alanya Vol.7 Issue 2, pp.137-144

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301823

pISSN:

2587-0319

Anahtar kelimeler:

Özet:

 Aim: In critical cases, electrolyte disturbances such as hypophosphatemia have been shown to be associated with mortality and in our study, we aimed to examine the relationship between hypophosphatemia, a symptom disorder with COVID-19, and death. Material and Methods: This study is a retrospective, cross-sectional investigation that encompasses patients diagnosed with COVID-19 and subsequently admitted for treatment at our hospital. Based on their serum phosphate levels, the patients were bifurcated into two distinct categories: those with serum phosphate levels below 2.5 mgdl, classified as hypophosphatemic, and those with levels above this benchmark, categorized as non-hypophosphatemic. The comparisons drawn between these two cohorts were facilitated using a range of statistical methodologies, and the resulting findings were subsequently analyzed and interpreted within this framework. Results: Compared to the hypophosphatemia group, the diagnoses of DM p0.001 and CKD p0.015 were statistically significantly higher in the group without hypophosphatemia. A statistically significant difference was found between phosphorus groups and mortality and length of stay p0.001. In addition, age and length of hospitalization were found to be statistically significantly higher in those who died compared to those who were alive p0.001; p0.002. Conclusions: Hypophosphatemia has been shown to be associated with mortality in patients with COVID-19, as in many studies and in our study, and it may be a biomarker in predicting severe disease.

 Aim: In critical cases, electrolyte disturbances such as hypophosphatemia have been shown to be associated with mortality and in our study, we aimed to examine the relationship between hypophosphatemia, a symptom disorder with COVID-19, and death. Material and Methods: This study is a retrospective, cross-sectional investigation that encompasses patients diagnosed with COVID-19 and subsequently admitted for treatment at our hospital. Based on their serum phosphate levels, the patients were bifurcated into two distinct categories: those with serum phosphate levels below 2.5 mgdl, classified as hypophosphatemic, and those with levels above this benchmark, categorized as non-hypophosphatemic. The comparisons drawn between these two cohorts were facilitated using a range of statistical methodologies, and the resulting findings were subsequently analyzed and interpreted within this framework. Results: Compared to the hypophosphatemia group, the diagnoses of DM p0.001 and CKD p0.015 were statistically significantly higher in the group without hypophosphatemia. A statistically significant difference was found between phosphorus groups and mortality and length of stay p0.001. In addition, age and length of hospitalization were found to be statistically significantly higher in those who died compared to those who were alive p0.001; p0.002. Conclusions: Hypophosphatemia has been shown to be associated with mortality in patients with COVID-19, as in many studies and in our study, and it may be a biomarker in predicting severe disease.

 Aim: In critical cases, electrolyte disturbances such as hypophosphatemia have been shown to be associated with mortality and in our study, we aimed to examine the relationship between hypophosphatemia, a symptom disorder with COVID-19, and death. Material and Methods: This study is a retrospective, cross-sectional investigation that encompasses patients diagnosed with COVID-19 and subsequently admitted for treatment at our hospital. Based on their serum phosphate levels, the patients were bifurcated into two distinct categories: those with serum phosphate levels below 2.5 mgdl, classified as hypophosphatemic, and those with levels above this benchmark, categorized as non-hypophosphatemic. The comparisons drawn between these two cohorts were facilitated using a range of statistical methodologies, and the resulting findings were subsequently analyzed and interpreted within this framework. Results: Compared to the hypophosphatemia group, the diagnoses of DM p0.001 and CKD p0.015 were statistically significantly higher in the group without hypophosphatemia. A statistically significant difference was found between phosphorus groups and mortality and length of stay p0.001. In addition, age and length of hospitalization were found to be statistically significantly higher in those who died compared to those who were alive p0.001; p0.002. Conclusions: Hypophosphatemia has been shown to be associated with mortality in patients with COVID-19, as in many studies and in our study, and it may be a biomarker in predicting severe disease.

 Amaç: Kritik hastalıklarda hipofosfatemi gibi elektrolit bozukluklarının mortalite ile ilişkisi gösterilmiştir. Biz de çalışmamızda COVID-19lu hastalarda bir elektrolit bozukluğu olan hipofosfateminin mortalite ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntemler: Bu retrospektif kesitsel çalışma, hastanemizde COVID-19 tanısı alıp, yatarak tedavi gören hastaları içermektedir. Hastalar, serum fosfor düzeylerine göre iki gruba ayrılmıştır: serum fosfor düzeyi 2.5 mgdlnin altında olanlar hipofosfatemi ve bu seviyenin üzerinde olanlar hipofosfatemi olmayanlar. İki grup arasındaki karşılaştırmalar, çeşitli istatistiksel yöntemler kullanılarak yapılmış ve sonuçlar bu veriler ışığında değerlendirilmiştir. Bulgular: Hipofosfatemi grubuyla karşılaştırıldığında, hipofosfatemi olmayan grupta DM p0,001 ve KBY p0,015 tanıları istatistiksel olarak anlamlı yüksekti. Fosfor grupları ile mortalite ve yatış süresi arasında da istatistiksel olarak anlamlı farklılık saptandı p0.001. Ayrıca yaş ve yatış süreleri sağ olanlara kıyasla exitus olanlarda istatistiksel olarak anlamlı yüksek bulundu p0.001; p0.002. Sonuç: Hipofosfatemi yapılan birçok çalışmada ve bizim çalışmamızda da olduğu gibi COVID-19lu hastalarda mortalite ile ilişkisi gösterilmiştir ve şiddetli hastalığı öngörmede bir biyobelirteç olabilir.

Makale detayları

Association of Hypophosphatemia with Morbidity and Mortality in Patients with COVID-19

Yazarlar:

Faruk Karandere | Deniz Yılmaz | Felemez Arslan | Ezgi Şahin | Sema Koyuncu

Yayıncı:

Alanya Alaaddin Keykubat Üniversitesi

Ana Başlıklar:

İç Hastalıkları

Dergi:

Acta Medica Alanya Vol.7 Issue 2, pp.137-144

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301823

pISSN:

2587-0319

COVID-19

Phosphorus

Diabetes Mellitus

MortalityCOVİD-19

Fosfor

Diyabetis Mellitus

Mortalite

Sayı

Makale detayları

Yazarlar: Faruk Karandere | Deniz Yılmaz | Felemez Arslan | Ezgi Şahin | Sema Koyuncu

Yayıncı: Alanya Alaaddin Keykubat Üniversitesi

Ana Başlıklar: İç Hastalıkları

Dergi: Acta Medica Alanya Vol.7 Issue 2, pp.137-144

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001301823

pISSN: 2587-0319

Sayı

Yazarlar:

Faruk Karandere | Deniz Yılmaz | Felemez Arslan | Ezgi Şahin | Sema Koyuncu

Yayıncı:

Alanya Alaaddin Keykubat Üniversitesi

Ana Başlıklar:

İç Hastalıkları

Dergi:

Acta Medica Alanya Vol.7 Issue 2, pp.137-144

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301823

pISSN:

2587-0319