Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Mohd Azlan Nafiah

Makale detayları

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Yazarlar:

Mohd Azlan Nafiah

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry | Pharmaceutical Biotechnology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.217-223

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346476

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Study on the chemical constituents of the dichloromethane DCM crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine 1, Omethylmoschatoline 2, lysicamine 3 and cepharadione-A 4 which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data 1H, 13C and LCMS and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

 Study on the chemical constituents of the dichloromethane DCM crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine 1, Omethylmoschatoline 2, lysicamine 3 and cepharadione-A 4 which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data 1H, 13C and LCMS and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

 Study on the chemical constituents of the dichloromethane DCM crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine 1, Omethylmoschatoline 2, lysicamine 3 and cepharadione-A 4 which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data 1H, 13C and LCMS and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

 Study on the chemical constituents of the dichloromethane DCM crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine 1, Omethylmoschatoline 2, lysicamine 3 and cepharadione-A 4 which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data 1H, 13C and LCMS and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

Makale detayları

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Yazarlar:

Mohd Azlan Nafiah

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry | Pharmaceutical Biotechnology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.217-223

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346476

pISSN:

2630-6344

Platymitra siamensis

Annonaceae

oxoaporphine alkaloids

MCF-7

cytotoxic activity

Sayı

Makale detayları

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Yazarlar: Mohd Azlan Nafiah

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biochemistry | Pharmaceutical Biotechnology

Dergi: Journal of Research in Pharmacy Vol.23 Issue 2, pp.217-223

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346476

pISSN: 2630-6344

Platymitra siamensis

Annonaceae

oxoaporphine alkaloids

MCF-7

cytotoxic activity

Sayı

Yazarlar:

Mohd Azlan Nafiah

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry | Pharmaceutical Biotechnology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.217-223

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346476

pISSN:

2630-6344