Assessment of Renal Dosimetry and Nephrotoxicity in Patients with Neuroendocrine Tumors Treated with 177Lu-DOTATATE

Armağan Aydın; Nami Yeyin; Mustafa Demir

Makale detayları

Assessment of Renal Dosimetry and Nephrotoxicity in Patients with Neuroendocrine Tumors Treated with 177Lu-DOTATATE

Yazarlar:

Armağan Aydın | Nami Yeyin | Mustafa Demir

Yayıncı:

Akdeniz University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.444-451

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357310

pISSN:

2687-2781

Anahtar kelimeler:

Özet:

 Aim: This study aimed to conduct dosimetry and evaluate renal toxicity based on calculated kidney doses and glomerular filtration rates GFR in 22 patients diagnosed with neuroendocrine tumors following the administration of 5550 MBq 150 mCi of 177Lu-DOTATATE radiopharmaceutical. Materials and Methods: Patients, aged between 35 and 80, including 14 males and 8 females, underwent 68Ga-DOTATATE PETCT scans to identify lesions and subsequently received treatment planning. Dosimetry of ¹⁷⁷Lu-DOTATATE was performed using whole-body imaging based on scans acquired at 4, 24, 48, and 72 hours post-administration. Results: According to our results, the average number of treatment cycles was 51, with an average total kidney dose of 24.323.5 Gy, average total BED dose of 27.92.5 Gy, average whole-body dose of 1.830.4 Gy, and average GFR of 69.9512.2. The correlation between kidney doses and GFR was calculated as R20.7945. The significance of the relationship between total kidney doses and total kidney BED doses was evaluated using the Mann-Whitney U test p0.0244. Conclusion: The study found that as the number of treatment cycles increased, the total kidney dose also increased; however, rapid declines in GFR were not observed, and none of the treated patients reached toxic doses in the kidneys.

 Aim: This study aimed to conduct dosimetry and evaluate renal toxicity based on calculated kidney doses and glomerular filtration rates GFR in 22 patients diagnosed with neuroendocrine tumors following the administration of 5550 MBq 150 mCi of 177Lu-DOTATATE radiopharmaceutical. Materials and Methods: Patients, aged between 35 and 80, including 14 males and 8 females, underwent 68Ga-DOTATATE PETCT scans to identify lesions and subsequently received treatment planning. Dosimetry of ¹⁷⁷Lu-DOTATATE was performed using whole-body imaging based on scans acquired at 4, 24, 48, and 72 hours post-administration. Results: According to our results, the average number of treatment cycles was 51, with an average total kidney dose of 24.323.5 Gy, average total BED dose of 27.92.5 Gy, average whole-body dose of 1.830.4 Gy, and average GFR of 69.9512.2. The correlation between kidney doses and GFR was calculated as R20.7945. The significance of the relationship between total kidney doses and total kidney BED doses was evaluated using the Mann-Whitney U test p0.0244. Conclusion: The study found that as the number of treatment cycles increased, the total kidney dose also increased; however, rapid declines in GFR were not observed, and none of the treated patients reached toxic doses in the kidneys.

 Aim: This study aimed to conduct dosimetry and evaluate renal toxicity based on calculated kidney doses and glomerular filtration rates GFR in 22 patients diagnosed with neuroendocrine tumors following the administration of 5550 MBq 150 mCi of 177Lu-DOTATATE radiopharmaceutical. Materials and Methods: Patients, aged between 35 and 80, including 14 males and 8 females, underwent 68Ga-DOTATATE PETCT scans to identify lesions and subsequently received treatment planning. Dosimetry of ¹⁷⁷Lu-DOTATATE was performed using whole-body imaging based on scans acquired at 4, 24, 48, and 72 hours post-administration. Results: According to our results, the average number of treatment cycles was 51, with an average total kidney dose of 24.323.5 Gy, average total BED dose of 27.92.5 Gy, average whole-body dose of 1.830.4 Gy, and average GFR of 69.9512.2. The correlation between kidney doses and GFR was calculated as R20.7945. The significance of the relationship between total kidney doses and total kidney BED doses was evaluated using the Mann-Whitney U test p0.0244. Conclusion: The study found that as the number of treatment cycles increased, the total kidney dose also increased; however, rapid declines in GFR were not observed, and none of the treated patients reached toxic doses in the kidneys.

 Amaç: Bu çalışmanın amacı, nöroendokrin tümör tanısı almış 22 hastada, 5550 MBq 150 mCi 177Lu-DOTATATE radyofarmasötik uygulaması sonrasında hesaplanan böbrek dozları ve glomerüler filtrasyon hızlarına GFR dayalı olarak dozimetri yapmak ve renal toksisiteyi değerlendirmektir. Materyal ve Metod: 35 ile 80 yaşları arasında, 14 erkek ve 8 kadından oluşan hastalar, lezyonları belirlemek için 68Ga-DOTATATE PETCT taramaları geçirmiş ve ardından tedavi planlaması yapılmıştır. 177Lu-DOTATATE tüm vücut görüntüleme kullanılarak dozimetri, uygulamadan 4, 24, 48 ve 72 saat sonra gerçekleştirilmiştir. Bulgular: Sonuçlarımıza göre, ortalama tedavi döngüsü sayısı 51, ortalama toplam böbrek dozu 24.323.5 Gy, ortalama toplam BED dozu 27.92.5 Gy, ortalama tüm vücut dozu 1.830.4 Gy ve ortalama GFR 69.9512.2 olarak bulunmuştur. Böbrek dozları ile GFR arasındaki korelasyon R²0.7945 olarak hesaplanmıştır. Toplam böbrek dozları ile toplam böbrek BED dozları arasındaki ilişkinin önemi Mann-Whitney U testi kullanılarak değerlendirilmiştir p0.0244. Sonuç: Çalışma, tedavi döngüsü sayısı arttıkça toplam böbrek dozunun da arttığını; ancak GFRde hızlı düşüşlerin gözlemlenmediğini ve tedavi edilen hastaların hiçbirinin böbreklerde toksik dozlara ulaşmadığını bulmuştur.

Makale detayları

Assessment of Renal Dosimetry and Nephrotoxicity in Patients with Neuroendocrine Tumors Treated with 177Lu-DOTATATE

Yazarlar:

Armağan Aydın | Nami Yeyin | Mustafa Demir

Yayıncı:

Akdeniz University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.444-451

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357310

pISSN:

2687-2781

MIRD method

68Ga-DOTATATE

177Lu-DOTATATE

neuroendocrine tumor

radionuclide dosimetryMIRD metodu

68Ga DOTATATE

177Lu DOTATATE

nöroendokrin tümör

radyonüklit dozimetri

Sayı

Makale detayları

Yazarlar: Armağan Aydın | Nami Yeyin | Mustafa Demir

Yayıncı: Akdeniz University

Ana Başlıklar: Nükleer Tıp

Dergi: Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.444-451

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357310

pISSN: 2687-2781

Sayı

Yazarlar:

Armağan Aydın | Nami Yeyin | Mustafa Demir

Yayıncı:

Akdeniz University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.444-451

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357310

pISSN:

2687-2781